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The crystal structures representing the catalytic states of zebrafish CYLD for Met1 (show DNMT1 ELISA Kits)- and Lys63-linked Ub chains and two distinct precatalytic states for Met1 (show DNMT1 ELISA Kits)-linked chains are presented.
TLR4 (show TLR4 ELISA Kits) activates CASPASE-8 (show CASP8 ELISA Kits) to cleave and remove the deubiquitinase cylindromatosis (CYLD) in a TRIF (show RNF138 ELISA Kits)- and RIPK1 (show RIPK1 ELISA Kits)-dependent manner to disable necroptosis in macrophages.
CYLD contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 (show NOX4 ELISA Kits) and may play a role in vascular remodeling.
this study shows that by polarization of the T cell cytokine response, CYLD can favor the development of allergic airway disease
Our findings underscore a critical tumor-suppressing role for functional intestinal epithelial CYLD in colitis-associated carcinogenesis
Deubiquitinase CYLD negatively regulates MyD88 (show MYD88 ELISA Kits)-mediated signaling by directly interacting with MyD88 (show MYD88 ELISA Kits) and deubiquitinating nontypeable Haemophilus influenzae (NTHi)-induced K63-linked polyubiquitination of MyD88 (show MYD88 ELISA Kits) at lysine 231.
CYLD interrupts the ERK (show EPHB2 ELISA Kits)- and p38 (show CRK ELISA Kits)-/AP-1 (show JUN ELISA Kits) and c-Myc (show MYC ELISA Kits) pathways to suppress Nrf2 (show NFE2L2 ELISA Kits)-operated antioxidative capacity, thereby enhancing oxidative stress in the heart.
Our data demonstrate that inefficient negative selection in the thymus of CYLD(ex7/8) mice result from a defect in mTEC maturation.
The deubiquitinating enzyme CYLD controls apical docking of basal bodies in ciliated epithelial cells.
Data show that the in utero death of NF-NF (show NFASC ELISA Kits)-kappaB (show NFKB1 ELISA Kits) essential modulator (NEMO (show IKBKG ELISA Kits)) and cylindromatosis protein double mutant mice is mediated by TNF (show TNF ELISA Kits) receptor 1 (TNFR1 (show TNFRSF1A ELISA Kits)) signaling and can be rescued by TNFR1 (show TNFRSF1A ELISA Kits) deficiency.
CYLD is a central regulator of apoptotic cell death in murine hepatocytes by controlling NF-kappaB (show NFKB1 ELISA Kits) dependent anti-apoptotic signaling.
The data reveal SPATA2 as a high-affinity binding partner of CYLD and HOIP (show RNF31 ELISA Kits), and a regulatory component of linear ubiquitin chain assembly complex-mediated NF-kappaB (show NFKB1 ELISA Kits) signaling.
The current investigations identified a subset of HPV-positive HNSCCs with mutations in the genes TRAF3 (show TRAF3 ELISA Kits) (tumor necrosis factor (show TNF ELISA Kits) receptor-associated factor 3) and CYLD (cylindromatosis lysine 63 deubiquitinase). Defects in TRAF3 (show TRAF3 ELISA Kits) and CYLD correlated with the activation of transcriptional factor nuclear factor kappaB, episomal HPV status of tumors, and improved patient survival.
The predicted PUB domain in the N-terminus of SPATA2 interacts with the USP domain of CYLD and SPATA2 is required for recruitment of CYLD to the TNF-alpha receptor-associated signaling complexes.
STAT3 (show STAT3 ELISA Kits) and miR (show MLXIP ELISA Kits)-181b control each other's expression in a positive feedback loop that regulates SFCs via CYLD pathway.
CYLD Promotes TNF-alpha (show TNF ELISA Kits)-Induced Cell Necrosis Mediated by RIP-1 in Human Lung Cancer Cells
Low CYLD expression is associated with hepatocellular carcinoma.
miR20a directly repressed the expression of CYLD, leading to activation of the NFkappaB (show NFKB1 ELISA Kits) pathway and the downstream targets, livin (show BIRC7 ELISA Kits) and survivin (show BIRC5 ELISA Kits), which potentially induced GC chemoresistance.
Data show that cylindromatosis (CYLD) overexpression and livin (show BIRC7 ELISA Kits) knockdown might improve gemcitabine chemosensitivity by decreasing autophagy and increasing apoptosis in bladder cancer (BCa (show BLNK ELISA Kits)) cells.
aberrantly expressed miR (show MLXIP ELISA Kits)-130b may regulate cell apoptosis and proliferation of human gastric cancer cells via CYLD, which appears to be a promising therapeutic target for gastric cancer
These results demonstrate the involvement of histone deacetylases in the down regulation of Cyld expression in hepatocellular carcinoma cells.
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cylindromatosis (turban tumor syndrome)
, probable ubiquitin carboxyl-terminal hydrolase CYLD-like
, ubiquitin carboxyl-terminal hydrolase CYLD
, deubiquitinating enzyme CYLD
, ubiquitin thioesterase CYLD
, ubiquitin thiolesterase CYLD
, ubiquitin-specific-processing protease CYLD
, probable ubiquitin carboxyl-terminal hydrolase CYLD
, retinitis pigmentosa 1 homolog
, ubiquitin specific peptidase like 2