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Data show that the caspase-activated DNase (CAD (show DFFB Proteins)) is activated when caspases cleave its endogenous inhibitor ICAD, resulting in the characteristic DNA laddering of apoptosis.
Data suggest that DFF45 gene silencing, when applied in combination with doxorubicin, may offer a therapeutic strategy for the treatment of breast cancer.
ICAD deficiency was associated with severe genomic instability.
mRNA splicing is actively driven toward the pro-apoptotic isoforms of Bim (show BCL2L11 Proteins), Bcl-x (show BCL2L1 Proteins), and ICAD in Pnn (show PNN Proteins)-depleted MCF-7 cells.
The DFF45 level in human endometrium corresponds to the respective phase of the menstrual cycle and decreases significantly after menopause.
study reveals a previously unrecognized function of miR (show MLXIP Proteins)-145 in DFF45 processing, which may underlie crucial aspects of cancer biology
The heterodimer, DFF40 (show DFFB Proteins)-DFF45, is localized to the chromatin fraction under apoptotic as well as non-apoptotic conditions.
DFF45 at chromosome 1 reveal rare allelic variants in neuroblastoma (show ARHGEF16 Proteins) tumors
NMR solution structure of the C-terminal domain of DFF45, which is essential for its chaperone-like activity
Hypoxia-induced cleavage of caspase-3 (show CASP3 Proteins) and DFF45/ICAD in human failed cardiomyocytes.
Co-transfection of mouse DFF45(-/-) fibroblasts with plasmids encoding human DFF40 (show DFFB Proteins) and DFF45 reversed the apoptosis resistance normally observed in these cells
a lack of DFF45 facilitates hippocampus-dependent nonspatial memory, as well as hippocampus-dependent spatial memory
apoptotic DNA fragmentation factor is required for the maintenance of genetic stability and may play a role in tumor suppression
Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
DNA fragmentation factor, 45kDa, alpha polypeptide
, DNA fragmentation factor subunit alpha
, DNA fragmentation factor 45 kDa subunit
, inhibitor of CAD