DFFA Protein (His tag)
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- Target See all DFFA Proteins
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DFFA protein is labelled with His tag.
- Purpose
- Recombinant Human DFFA Protein (His Tag)
- Sequence
- Met 1-Thr331
- Characteristics
- Recombinant Human DNA Fragmentation Factor Subunit alpha is produced by our E.coli expression system and the target gene encoding Met1-Thr331 is expressed with a 6His tag at the N-terminus.
- Purity
- > 95 % as determined by reducing SDS-PAGE.
- Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product DFFA Protein
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DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 1-331) protein (His tag)
DFFA Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 1-331) protein (GST tag)DFFA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (AA 231-331) protein (GST tag)DFFA Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)DFFA Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Restrictions
- For Research Use only
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- Format
- Frozen, Liquid
- Buffer
- Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- Storage
- -20 °C
- Storage Comment
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- Target
- DFFA (DNA Fragmentation Factor, 45kDa, alpha Polypeptide (DFFA))
- Alternative Name
- DFFA (DFFA Products)
- Synonyms
- DFF-45 Protein, DFF1 Protein, ICAD Protein, A330085O09Rik Protein, DFF35 Protein, Dff45 Protein, ICAD-L Protein, ICAD-S Protein, DFFA Protein, zgc:92229 Protein, DNA fragmentation factor subunit alpha Protein, DNA fragmentation factor, alpha subunit Protein, DNA fragmentation factor, 45kDa, alpha polypeptide Protein, DNA fragmentation factor, alpha polypeptide Protein, DFFA Protein, Dffa Protein, dffa Protein
- Background
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Background: DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
Synonym: DNA Fragmentation Factor Subunit Alpha, DNA Fragmentation Factor 45 kDa Subunit, DFF-45, Inhibitor of CAD, ICAD, DFFA, DFF1, DFF45, H13
- Molecular Weight
- 38.7 kDa
- UniProt
- O00273
- Pathways
- Apoptosis, Caspase Cascade in Apoptosis
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