Browse our anti-FADD (FADD) Antibodies

Full name:
anti-Fas (TNFRSF6)-Associated Via Death Domain Antibodies (FADD)
On www.antibodies-online.com are 274 Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibodies from 30 different suppliers available. Additionally we are shipping FADD Kits (13) and FADD Proteins (13) and many more products for this protein. A total of 325 FADD products are currently listed.
Synonyms:
Mort1, Mort1/FADD, TNFRSF6
list all antibodies Gene Name GeneID UniProt
FADD 8772 Q13158
FADD 14082 Q61160
FADD 266610  

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anti-Human FADD Antibodies:

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anti-Rat (Rattus) FADD Antibodies:

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Top referenced anti-FADD Antibodies

  1. Human Monoclonal FADD Primary Antibody for WB - ABIN395764 : Silva, Blanton, Parrado, Melo, Morato, Reis, Dias, Castro, Vasconcelos, Goddard, Barreto, Reis, Teixeira: Dengue hemorrhagic fever is associated with polymorphisms in JAK1. in European journal of human genetics : EJHG 2010 (PubMed)
    Show all 5 references for 395764

  2. Human Monoclonal FADD Primary Antibody for IF, IP - ABIN967944 : Chang, Xing, Pan, Algeciras-Schimnich, Barnhart, Yaish-Ohad, Peter, Yang: c-FLIP(L) is a dual function regulator for caspase-8 activation and CD95-mediated apoptosis. in The EMBO journal 2002 (PubMed)
    Show all 5 references for 967944

  3. Human Polyclonal FADD Primary Antibody for EIA, IHC (p) - ABIN358126 : Hsu, Shu, Pan, Goeddel: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. in Cell 1996 (PubMed)
    Show all 3 references for 358126

  4. Human Polyclonal FADD Primary Antibody for IP, WB - ABIN222894 : Chen, Texada, Duggan, Liang, Reden, Kooragayala, Langford: Surface calreticulin mediates muramyl dipeptide-induced apoptosis in RK13 cells. in The Journal of biological chemistry 2005 (PubMed)
    Show all 3 references for 222894

  5. Human Monoclonal FADD Primary Antibody for EIA, IHC (p) - ABIN317514 : Bannerman, Tupper, Kelly, Winn, Harlan: The Fas-associated death domain protein suppresses activation of NF-kappa B by LPS and IL-1 beta. in The Journal of clinical investigation 2002 (PubMed)
    Show all 3 references for 317514

  6. Mouse (Murine) Polyclonal FADD Primary Antibody for WB - ABIN389559 : Zhang, Winoto: A mouse Fas-associated protein with homology to the human Mort1/FADD protein is essential for Fas-induced apoptosis. in Molecular and cellular biology 1996 (PubMed)
    Show all 2 references for 389559

  7. Human Polyclonal FADD Primary Antibody for IF, IHC - ABIN1534444 : Chinnaiyan, ORourke, Tewari, Dixit: FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. in Cell 1995 (PubMed)

  8. Human Polyclonal FADD Primary Antibody for IHC (p), WB - ABIN669471 : Soni, Adebiyi: Early septic insult in neonatal pigs increases serum and urinary soluble Fas ligand and decreases kidney function without inducing significant renal apoptosis. in Renal failure 2016 (PubMed)

  9. Human Polyclonal FADD Primary Antibody for IHC, WB - ABIN2792110 : Thomas, Henson, Reed, Salsbury, Thorburn: Direct binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD. in The Journal of biological chemistry 2004 (PubMed)

More Antibodies against FADD Interaction Partners

Human Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. Caspase-8 can serve in two distinct roles in response to TRAIL receptor engagement, as a scaffold for assembly of a Caspase-8-FADD-RIPK1 "FADDosome" complex, leading to NFkappaB-dependent inflammation, or as a protease that promotes apoptosis.

  2. Using the tDED filament structure as a template, structural analyses reveal the interaction surfaces between FADD and caspase-8 (show CASP8 Antibodies) and the distinct mechanisms of regulation by cFLIP (show CFLAR Antibodies) and MC159 through comingling and capping, respectively.

  3. This study reveals an essential role of SUMOylated FADD in Drp1 (show CRMP1 Antibodies)- and caspase-10 (show CASP10 Antibodies)-dependent necrosis.

  4. In myelodysplastic syndrome, FADD expression is regulated by SPAG6 (show SPAG6 Antibodies) which influences its interaction with TRAIL death receptors.

  5. High levels of FADD and caspase-8 (show CASP8 Antibodies), but not caspase-3 (show CASP3 Antibodies), were associated with increased incidence of coronary events in subjects from the general population.

  6. Both Fas associated via death domain gene copy number amplification and high protein expression were significantly associated with lymph node metastasis and had the shortest disease-free survival and overall survival.

  7. FADD, as well as NEMO (show IKBKG Antibodies), is a substrate for LUBAC ubiquitin ligase (E3) complex, composed of the HOIP (show RNF31 Antibodies), HOIL-1L (show RBCK1 Antibodies), and SHARPIN (show SHARPIN Antibodies) subunits.

  8. autoinflammation-associated H443P nlrc4 (show NLRC4 Antibodies) mutant is altered in interaction with SUG1 (show PSMC5 Antibodies) and ubiquitinated proteins, triggering constitutive caspase-8 (show CASP8 Antibodies)-mediated cell death dependent on FADD but independent of Ser (show SIGLEC1 Antibodies)(533) phosphorylation.

  9. this study shows that C5a signaling induces apoptosis in brain vascular endothelial cells in experimental lupus through activation of FADD

  10. Authors identify non-canonical nuclear factor-kappaB (NF-kappaB (show NFKB1 Antibodies)) signaling up regulated and it was directly linked with the tumor necrosis with MT2A (show MT2 Antibodies) and pFADD genes. pFADD with MT2A (show MT2 Antibodies) can inhibit the apoptosis and promote proliferation, of colorectal cancer cells.

Mouse (Murine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. The authors conclude that FADD is a master regulator of glucose and fat metabolism.

  2. Mice deficient in RIPK3 (show RIPK3 Antibodies) or doubly deficient in MLKL and FADD, but not MLKL alone, are more susceptible to influenza A virus than their wild-type counterparts, revealing an important role for RIPK3 (show RIPK3 Antibodies)-mediated apoptosis in antiviral immunity.

  3. Wild-type cells can execute apoptosis via both, the mitochondrial and the receptor-mediated pathway whereas FADD-deficient cells can only activate the intrinsic pathway. There is a difference in UVC radiation response between two cell lines indicating the role of FADD in the selection of cell death modality.

  4. This study reveals an essential role of SUMOylated FADD in Drp1 (show CRMP1 Antibodies)- and caspase-10 (show CASP10 Antibodies)-dependent necrosis.

  5. knockdown of cFLIPL and induced expression of FADD rapidly accumulate intracellular ROS (show ROS1 Antibodies) accompanied by JNK1 (show MAPK8 Antibodies) activation to substantiate apoptosis.

  6. A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

  7. Deletion of FADD in macrophages and granulocytes results in RIP3 (show MPRIP Antibodies)- and MyD88 (show MYD88 Antibodies)-dependent systemic inflammation.

  8. A constitutively phosphoryl-mimicking mutation of Fas (show FAS Antibodies)-associated death domain (FADD-D) enhances Notch-1 (show NOTCH1 Antibodies) signaling and compromises Wnt (show WNT2 Antibodies) signaling in both cultured myoblasts and regenerating muscles.

  9. Beta amyloid-induced upregulation of death receptor 6 (show TNFRSF21 Antibodies) accelerates the toxic effect of N-terminal fragment of amyloid precursor protein (show APP Antibodies)

  10. Phosphorylation of FADD by the kinase CK1alpha (show CSNK1A1 Antibodies) promotes KRASG12D-induced lung cancer.

Pig (Porcine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. FADD induces apoptosis

Cow (Bovine) Fas (TNFRSF6)-Associated Via Death Domain (FADD) interaction partners

  1. mapping and sequencing of bovine FADD cDNA, and characterization of its expression in endothelial cells

FADD Antigen Profile

Antigen Summary

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Alternative names and synonyms associated with FADD

  • Fas (TNFRSF6)-associated via death domain (FADD) antibody
  • Fas (TNFRSF6)-associated via death domain (Fadd) antibody
  • Mort1 antibody
  • Mort1/FADD antibody
  • TNFRSF6 antibody

Protein level used designations for FADD

Fas-associating death domain-containing protein , Fas-associating protein with death domain , growth-inhibiting gene 3 protein , mediator of receptor induced toxicity , mediator of receptor-induced toxicity , protein FADD , FAS-associated death domain protein , FAS-associating death domain-containing protein , Fas (TNF receptor superfamily, member 6) , Fas-associated via death domain

GENE ID SPECIES
8772 Homo sapiens
14082 Mus musculus
266610 Rattus norvegicus
595129 Sus scrofa
493720 Bos taurus
611694 Canis lupus familiaris
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