Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST (show DDOST Proteins).
The effect of topical TREX1 knockdown and local interferon (show IFNA Proteins) production on HIV transmission in human cervicovaginal explants and humanized mice, is reported.
data do not support the concept of retroelement-derived cDNA as key triggers of systemic autoimmunity in Trex1-deficient humans and mice
Aicardi-Goutieres syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease (show EXO1 Proteins)-independent ORF1p depletion.
Analysis of mRNA expression profiles in breast tumors demonstrates that those with lower Trex1 and higher BLM and EXO1 (show EXO1 Proteins) expression levels are associated with poor prognosis
showed that patients with SSc (show CYP11A1 Proteins) or SLE have AAb against EphB2 (show EPHB2 Proteins), a protein involved in angiogenesis, and THEX1 (show ERI1 Proteins), a 3'-5' exoribonuclease involved in histone mRNA degradation.
The expression of TREX1 was closely related to the cytobiology characteristics of osteosarcoma stem cell.
Heterozygous mutations in TREX1 were reported in SLE patients.
This study reviewed that Neurologic Phenotypes Associated with Mutations in TREX1 in patients with Aicardi-Goutieres Syndrome.
Aicardie-Goutieres syndrome is described in a patient with a homozygous p.Arg114His mutation in the TREX1 gene.
the cell-cycle-dependent post-translation modification of TREX1 regulates its interaction with OST.
Trex1 expression in dendritic cells is essential to prevent breakdown of self-tolerance ensuing from aberrant detection of endogenous DNA.
Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 knockout (Trex1-/-) cells.
Data show that cyclic GMP (show NT5C2 Proteins)-AMP (show TMPRSS5 Proteins) synthase (cGAS) is essential for all aspects of the autoimmune disease in 3' repair exonuclease (show EXO1 Proteins) Trex1 knockout mice.
Dysfunctional dsDNA degradation by TREX1 D18N induces disease in mice that recapitulates many characteristics of human lupus.
DC activation induced by TLR3 (show TLR3 Proteins), -4, -7, and -9 ligands also augments Trex1 expression through autocrine IFN-beta (show IFNB1 Proteins) production and triggering of the IFN signaling pathway
knocking out the DNA sensor cyclic GMP (show NT5C2 Proteins)-AMP (show TMPRSS5 Proteins) synthase completely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells.
Spontaneous type I INF (show GIF Proteins) dependent cutaneous pathology in TREX1 deficiency illustrates common pathogenetic pathway in chilblain lupus.
This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.
three prime repair exonuclease 1
, 3' repair exonuclease 1
, 3'-5' exonuclease TREX1
, DNase III
, deoxyribonuclease III
, three prime exonuclease 1
, trophoblast expressed 1