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Browse our TREX1 Proteins (TREX1)

Full name:
three Prime Repair Exonuclease 1 Proteins (TREX1)
On are 6 three Prime Repair Exonuclease 1 (TREX1) Proteins from 4 different suppliers available. Additionally we are shipping TREX1 Antibodies (29) and many more products for this protein. A total of 42 TREX1 products are currently listed.
1661, AGS1, AU041952, CRV, DRN3, HERNS, RGD1309596
list all proteins Gene Name GeneID UniProt
TREX1 11277 Q9NSU2
TREX1 22040 Q91XB0
TREX1 100049583  

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TREX1 Proteins (TREX1) by Origin

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Human three Prime Repair Exonuclease 1 (TREX1) interaction partners

  1. CDK11 was found associated with the TREX/THOC, which recruited this kinase to DNA. Once at the viral genome, CDK11 phosphorylated serines at position 2 in the CTD of RNAPII, which increased levels of cleavage and polyadenylation factors at the HIV 3' end. In its absence, cleavage of viral transcripts was greatly attenuated.

  2. Aicardi-Goutieres syndrome 1 is caused by mutations in the three prime repair exonuclease 1 gene (TREX1, MIM (show MTSS1 Proteins) 606609).

  3. Functional analysis of retinal vasculopathy with cerebral leukodystrophy-associated TREX1 T270 frameshift-mutated fibroblasts showed a prevalent localization of the protein in the cytosol, rather than in the perinuclear region

  4. Here we briefly describe the human diseases so-far associated with mutations in TREX1, which include Aicardi-Goutieres syndrome, familial chilblain lupus, systemic lupus erythematosus and retinal vasculopathy with cerebral leukodystrophy

  5. Studies indicate that the biosensing strategy is based on the protection of DNA duplex from exonuclease (show EXO1 Proteins) III (Exo III)-mediated digestion by specific binding of estrogen receptor (ER (show ESR1 Proteins)) to its DNA response element.

  6. The authors observed that the minor allele of SNP rs3135941 in Trex1 is associated with faster HIV-1 disease progression.

  7. Unlike previously reported TREX1 mutations, which affect Exo I or Exo II domains, the mutation presented here alters the Exo III domain, suggesting a role of mutations within the catalytic Exo domains in the pathogenesis of familial chilblain lupus

  8. Data suggest that the 3'-5' DNA exonuclease (show EXO1 Proteins) TREX1 may contribute to stabilization of poly(ADP-ribose) polymerase-1 (PARP1 (show PARP1 Proteins)) levels in the DNA damage response and its activity.

  9. knocking out the DNA sensor cyclic GMP (show NT5C2 Proteins)-AMP (show APRT Proteins) synthase completely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells.

  10. Data indicate that the single nucleotide polymorphism rs3135945 was significantly associated with HIV infection, emphasizing the involvement of TREX-1 in the anti-HIV response.

Mouse (Murine) three Prime Repair Exonuclease 1 (TREX1) interaction partners

  1. Data show that oligosaccharyltransferase (OST) activity is dysregulated in three prime exonuclease 1 knockout (Trex1-/-) cells.

  2. Data show that cyclic GMP (show NT5C2 Proteins)-AMP (show TMPRSS5 Proteins) synthase (cGAS) is essential for all aspects of the autoimmune disease in 3' repair exonuclease (show EXO1 Proteins) Trex1 knockout mice.

  3. Dysfunctional dsDNA degradation by TREX1 D18N induces disease in mice that recapitulates many characteristics of human lupus.

  4. DC activation induced by TLR3 (show TLR3 Proteins), -4, -7, and -9 ligands also augments Trex1 expression through autocrine IFN-beta (show IFNB1 Proteins) production and triggering of the IFN signaling pathway

  5. knocking out the DNA sensor cyclic GMP (show NT5C2 Proteins)-AMP (show TMPRSS5 Proteins) synthase completely abrogates spontaneous induction of IFN-stimulated genes in TREX1-deficient cells.

  6. Spontaneous type I INF (show GIF Proteins) dependent cutaneous pathology in TREX1 deficiency illustrates common pathogenetic pathway in chilblain lupus.

  7. Upon proinflammatory stimulation, Trex1(-/-) macrophages increase CD86 (show CD86 Proteins), TNF-alpha (show TNF Proteins) & IFN-alpha (show IFNA Proteins) production, & Ag presentation to CD4 (show CD4 Proteins)(+) T cells, but decrease apoptotic T cell clearance. Trex1 is a negative regulator of macrophage inflammatory activation.

  8. Oxidized DNA Is less susceptible to TREX1 degradation; the oxidized base 8-hydroxyguanosine, a marker of oxidative damage in DNA, potentiated cytosolic immune recognition by decreasing its susceptibility to 3' repair exonuclease 1 -mediated degradation

  9. regulates lysosomal biogenesis and interferon (show IFNA Proteins)-independent activation of antiviral genes

  10. The structures of the mutant TREX1 proteins provide insight into the dysfunction relating to human disease.

TREX1 Protein Profile

Protein Summary

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with TREX1

  • three prime repair exonuclease 1 (CpipJ_CPIJ012074)
  • three prime repair exonuclease 1 (Tsp_03749)
  • three prime repair exonuclease 1 (TREX1)
  • three prime repair exonuclease 1 (Trex1)
  • 1661 protein
  • AGS1 protein
  • AU041952 protein
  • CRV protein
  • DRN3 protein
  • HERNS protein
  • RGD1309596 protein

Protein level used designations for TREX1

three prime repair exonuclease 1 , 3' repair exonuclease 1 , 3'-5' exonuclease TREX1 , DNase III , deoxyribonuclease III , three prime exonuclease 1 , trophoblast expressed 1

6045034 Culex quinquefasciatus
10910476 Trichinella spiralis
11277 Homo sapiens
22040 Mus musculus
100049583 Rattus norvegicus
282099 Bos taurus
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