Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human XIAP Antibodies:
anti-Mouse (Murine) XIAP Antibodies:
anti-Rat (Rattus) XIAP Antibodies:
Go to our pre-filtered search.
Dog (Canine) Monoclonal XIAP Primary Antibody for IF, IP - ABIN968132
Duckett, Nava, Gedrich, Clem, Van Dongen, Gilfillan, Shiels, Hardwick, Thompson: A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. in The EMBO journal 1996
Show all 6 Pubmed References
Frog Monoclonal XIAP Primary Antibody for IF, IP - ABIN968163
Deng, Lin, Wu: TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO. in Genes & development 2002
Show all 5 Pubmed References
Frog Monoclonal XIAP Primary Antibody for IF, IP - ABIN968164
Fulda, Meyer, Debatin: Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. in Cancer research 2000
Show all 5 Pubmed References
Dog (Canine) Monoclonal XIAP Primary Antibody for IF, IP - ABIN968133
Lee, Chung: Diverse functions of BRCA1 in the DNA damage response. in Expert reviews in molecular medicine 2004
Show all 6 Pubmed References
Human Polyclonal XIAP Primary Antibody for IF (cc), IF (p) - ABIN674364
Chen, Bai, Zhong, Xie, Long, Yang, Wu, Jia, Wang: Wogonin has multiple anti-cancer effects by regulating c-Myc/SKP2/Fbw7? and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549. in PLoS ONE 2013
Show all 4 Pubmed References
Human Polyclonal XIAP Primary Antibody for IHC (p), WB - ABIN3044425
Li, Zhang, Fang, Yan, Zhao, Feng, Ma, Ye: Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1. in Biochemical and biophysical research communications 2013
Show all 3 Pubmed References
Human Polyclonal XIAP Primary Antibody for IHC, ELISA - ABIN1003492
Schimmer: Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. in Cancer research 2004
Show all 4 Pubmed References
Human Polyclonal XIAP Primary Antibody for IHC, IHC (p) - ABIN4366393
Lee, Jiffar, Kupferman: A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma. in PLoS ONE 2012
Show all 2 Pubmed References
Human Polyclonal XIAP Primary Antibody for ICC, IF - ABIN4366395
Fann, Lee, Manzanero, Tang, Gelderblom, Chunduri, Bernreuther, Glatzel, Cheng, Thundyil, Widiapradja, Lok, Foo, Wang, Li, Drummond, Basta, Magnus, Jo, Mattson, Sobey, Arumugam: Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. in Cell death & disease 2013
The authors find that primary human aggressive B-cell lymphoma samples exhibit high USP9X (show USP9X Antibodies) expression that correlate with XIAP overexpression.
Findings reveal important new insights into how XIAP 3'UTR (show UTS2R Antibodies) works, suggesting that the non-coding XIAP 3'UTR (show UTS2R Antibodies) serves as a competitor for miRNA binding and subsequently inactivates miRNA functions, by which XIAP 3'UTR (show UTS2R Antibodies) frees the target mRNAs from being repressed.
XIAP is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1 (show CDK1 Antibodies)-cyclin-B1 (show CCNB1 Antibodies) at S40.
our findings suggest that X-linked inhibitor of apoptosis protein 3'-untranslated region serves as a competitive endogenous RNA for HMGA2 to activate hepatocellular carcinoma progression by arresting endogenous let-7a-5p.
In chronic myeloid leukemia (show BCL11A Antibodies) cells, EZH2 (show EZH2 Antibodies) modulates epigenetic changes at DNA methylated regions encoding miR (show MLXIP Antibodies)-219 and downregulates the level of miR (show MLXIP Antibodies)-219. Downregulation of miR (show MLXIP Antibodies)-219 results in upregulation of XIAP and supports the survival of leukemia cells.
IFNgamma positively affects NOD2 (show NOD2 Antibodies)-mediated signaling in human conventional dendritic cells, in a manner considerably dependent on XIAP and partially dependent on mTOR (show FRAP1 Antibodies).
miR (show MLXIP Antibodies)-137 expression is inversely correlated with the level of XIAP protein in both ovarian cancer tissues and cell lines. these data suggest that multiple miRNAs can regulate XIAP via its 3'UTR (show UTS2R Antibodies). miR (show MLXIP Antibodies)-137 can sensitise ovarian cancer cells to cisplatin-induced apoptosis, providing new insight into overcoming drug resistance in ovarian cancer
results of this work support the role of XIAP in mediating NOD2 (show NOD2 Antibodies) signaling while reconciling the role of X-linked lymphoproliferative syndrome 2 and very-early-onset inflammatory bowel disease XIAP mutations in inflammatory cell death and provide a set of tools and framework to rapidly test newly discovered XIAP variants.
Using recombinant proteins, this study investigated the influence of survivin (show BIRC5 Antibodies) on the inhibition of caspase-9 (show CASP9 Antibodies) by XIAP in vitro. With a fluorescence-based assay for the apoptosome-stimulated activity of caspase-9 (show CASP9 Antibodies), the study shows that survivin (show BIRC5 Antibodies) has no effect on the inhibition of caspase-9 (show CASP9 Antibodies) by XIAP, neither in the presence nor in the absence of Smac (show DIABLO Antibodies).
Study found a negative correlation between Smac (show DIABLO Antibodies) and XIAP at the level of protein but not mRNA in non-small cell lung carcinoma (NSCLC) patients. Overexpressed XIAP could degrade through ubiquitination, the mature Smac (show DIABLO Antibodies) inhibiting NSCLC apoptosis.
These results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 (show CASP3 Antibodies) activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.
XIAP antagonizes the switch from TNFalpha (show TNF Antibodies)-induced apoptosis to necroptosis in mouse neutrophils.
Results show that XIAP binds to the C terminus of Ptch1 (show PTCH1 Antibodies) and mediates the death-dependent function of Ptch1 (show PTCH1 Antibodies).
XIAP modulates ubiquitylation of RIP1 (show RALBP1 Antibodies) and suppresses RIP3 (show MPRIP Antibodies)-dependent cell death and inflammasome activation in response to TNF (show TNF Antibodies)-signaling in innate immune cells.
XIAP deficiency selectively impaired B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10 (show BCL10 Antibodies))-mediated innate responses to dectin-1 (show CLEC7A Antibodies) ligands but did not affect responses to various Toll (show TLR4 Antibodies)-like receptor agonists.
XIAP mRNA level was also reduced in the BRE (show BRE Antibodies)-depleted cells, but the level of reduction was less profound than that of the protein level. However, BRE (show BRE Antibodies) could not delay protein turnover of XIAP.
Identify xIAP and cIAP1 (show BIRC2 Antibodies) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.
XIAP-/- DRG sensory neurons degenerate more rapidly and contain more active caspase-3 (show CASP3 Antibodies).
XIAP ubiquitylates RIPK2 (show RIPK2 Antibodies) and recruits the linear ubiquitin chain assembly complex to NOD2 (show NOD2 Antibodies)
XIAP is expressed in oligodendrocytes in vivo and in vitro. Increased XIAP expression is associated with protection against selected cell death pathways, whereas decreased expression increases oligodendroglial cell death.
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
X-linked inhibitor of apoptosis protein
, baculoviral IAP repeat-containing 4
, baculoviral IAP-repeat containing protein 4
, Baculoviral IAP repeat-containing protein 4
, E3 ubiquitin-protein ligase XIAP
, X-linked IAP
, IAP-like protein
, baculoviral IAP repeat-containing protein 4
, inhibitor of apoptosis protein 3
, IAP homolog A
, apoptosis inhibitor 3
, apoptosis inhibitor protein 3