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Browse our XIAP Proteins (XIAP)

Full name:
X-Linked Inhibitor of Apoptosis Proteins (XIAP)
On are 10 X-Linked Inhibitor of Apoptosis (XIAP) Proteins from 7 different suppliers available. Additionally we are shipping XIAP Antibodies (178) and XIAP Kits (18) and many more products for this protein. A total of 220 XIAP products are currently listed.
1110015C02Rik, Aipa, Api3, Birc4, hIAP-3, hIAP3, IAP-3, IAP3, ILP-1, ILP1, MIHA, mXIAP, riap3, XLP2, xxiap
list all proteins Gene Name GeneID UniProt
XIAP 331 P98170
Mouse XIAP XIAP 11798 Q60989
XIAP 63879 Q9R0I6

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Human X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. miR (show MLXIP Proteins)-24 plays an important role in regulating the cell survival of periodontal ligament cells through targeting XIAP.

  2. Herein, CEUS imaging during cancer treatment played an important role in evaluating the therapeutic effects of XIAP siRNA ultrasound-responsive microbubble are a promising theranostic system for cancer gene therapy.

  3. herefore targeting XIAP and NF-kappaB (show NFKB1 Proteins) pathways simultaneously can be investigated in more detail to make use of embelin and celastrol as a combination therapy of cancer

  4. Data demonstrate that the most potent caspase (show CASP3 Proteins) inhibitor, X-linked inhibitor of apoptosis protein (XIAP), overexpressed in IBC, drives resistance to ADCC mediated by cetuximab (anti-EGFR (show EGFR Proteins)) and trastuzumab (anti-HER2 (show ERBB2 Proteins)). Overexpression of XIAP in parental IBC cell lines enhances resistance to ADCC.

  5. High XIAP expression is associated with Pancreatic cancer.

  6. Treatment of isolinderalactone increased the protein level of SCOS3, decreased phosphorylation of the STAT3 (show STAT3 Proteins) and suppressed expression of the down-stream genes of the X-linked inhibitor of apoptosis protein

  7. we identified miR (show MLXIP Proteins)-215 as a potential tumor suppressor in patients with EOC downregulating expression of the oncogenic regulator XIAP

  8. This paper highlights that targeting the BMP and TGFbeta (show TGFB1 Proteins) type I and type II receptors causes a downregulation of XIAP, TAK1 (show MAP3K7 Proteins), and Id1 (show ID1 Proteins) leading to cell death of lung cancer cells.

  9. Overexpression of FOXM1 (show FOXM1 Proteins), XIAP, and Survivin (show BIRC5 Proteins) contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients.

  10. Abnormal expression of XIAP may be an important underlying mechanism in the development of bicuspid aortic valve and renal malformations in Turner syndrome.

Mouse (Murine) X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. Results show that XIAP binds to the C terminus of Ptch1 (show PTCH1 Proteins) and mediates the death-dependent function of Ptch1 (show PTCH1 Proteins).

  2. XIAP modulates ubiquitylation of RIP1 (show RALBP1 Proteins) and suppresses RIP3-dependent cell death and inflammasome activation in response to TNF (show TNF Proteins)-signaling in innate immune cells.

  3. XIAP deficiency selectively impaired B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10 (show BCL10 Proteins))-mediated innate responses to dectin-1 (show CLEC7A Proteins) ligands but did not affect responses to various Toll (show TLR4 Proteins)-like receptor agonists.

  4. XIAP mRNA level was also reduced in the BRE (show BRE Proteins)-depleted cells, but the level of reduction was less profound than that of the protein level. However, BRE (show BRE Proteins) could not delay protein turnover of XIAP.

  5. Identify xIAP and cIAP1 (show BIRC2 Proteins) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.

  6. XIAP-/- DRG sensory neurons degenerate more rapidly and contain more active caspase-3 (show CASP3 Proteins).

  7. XIAP ubiquitylates RIPK2 and recruits the linear ubiquitin chain assembly complex to NOD2

  8. XIAP is expressed in oligodendrocytes in vivo and in vitro. Increased XIAP expression is associated with protection against selected cell death pathways, whereas decreased expression increases oligodendroglial cell death.

  9. ARTS (Septin 4 (show SEPT4 Proteins)) promotes apoptosis mainly through binding and antagonizing XIAP.

  10. A critical role is identified for XIAP in regulating neuronal apoptosis in neonatal brain injury.

XIAP Protein Profile

Protein Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Alternative names and synonyms associated with XIAP

  • X-linked inhibitor of apoptosis (XIAP)
  • X-linked inhibitor of apoptosis (xiap)
  • X-linked inhibitor of apoptosis (Xiap)
  • 1110015C02Rik protein
  • Aipa protein
  • Api3 protein
  • Birc4 protein
  • hIAP-3 protein
  • hIAP3 protein
  • IAP-3 protein
  • IAP3 protein
  • ILP-1 protein
  • ILP1 protein
  • MIHA protein
  • mXIAP protein
  • riap3 protein
  • XLP2 protein
  • xxiap protein

Protein level used designations for XIAP

X-linked inhibitor of apoptosis protein , baculoviral IAP repeat-containing 4 , baculoviral IAP-repeat containing protein 4 , Baculoviral IAP repeat-containing protein 4 , E3 ubiquitin-protein ligase XIAP , X-linked IAP , IAP-like protein , baculoviral IAP repeat-containing protein 4 , inhibitor of apoptosis protein 3 , IAP homolog A , IAP-3 , apoptosis inhibitor 3 , mIAP-3 , mIAP3 , RIAP-3 , apoptosis inhibitor protein 3

442989 Canis lupus familiaris
594971 Xenopus (Silurana) tropicalis
331 Homo sapiens
11798 Mus musculus
63879 Rattus norvegicus
733235 Xenopus laevis
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