Browse our XIAP Proteins (XIAP)

Full name:
X-Linked Inhibitor of Apoptosis Proteins (XIAP)
On are 15 X-Linked Inhibitor of Apoptosis (XIAP) Proteins from 8 different suppliers available. Additionally we are shipping XIAP Antibodies (178) and XIAP Kits (19) and many more products for this protein. A total of 227 XIAP products are currently listed.
1110015C02Rik, Aipa, Api3, Birc4, hIAP-3, hIAP3, IAP-3, IAP3, ILP-1, ILP1, MIHA, mXIAP, riap3, XLP2, xxiap
list all proteins Gene Name GeneID UniProt
XIAP 331 P98170
XIAP 11798 Q60989
XIAP 63879 Q9R0I6

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Human X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. Findings reveal important new insights into how XIAP 3'UTR works, suggesting that the non-coding XIAP 3'UTR serves as a competitor for miRNA binding and subsequently inactivates miRNA functions, by which XIAP 3'UTR frees the target mRNAs from being repressed.

  2. XIAP is stable during mitotic arrest, but its function is controlled through phosphorylation by the mitotic kinase CDK1 (show CDK1 Proteins)-cyclin-B1 (show CCNB1 Proteins) at S40.

  3. our findings suggest that X-linked inhibitor of apoptosis protein 3'-untranslated region serves as a competitive endogenous RNA for HMGA2 to activate hepatocellular carcinoma progression by arresting endogenous let-7a-5p.

  4. In chronic myeloid leukemia (show BCL11A Proteins) cells, EZH2 (show EZH2 Proteins) modulates epigenetic changes at DNA methylated regions encoding miR (show MLXIP Proteins)-219 and downregulates the level of miR (show MLXIP Proteins)-219. Downregulation of miR (show MLXIP Proteins)-219 results in upregulation of XIAP and supports the survival of leukemia cells.

  5. IFNgamma positively affects NOD2-mediated signaling in human conventional dendritic cells, in a manner considerably dependent on XIAP and partially dependent on mTOR (show FRAP1 Proteins).

  6. miR (show MLXIP Proteins)-137 expression is inversely correlated with the level of XIAP protein in both ovarian cancer tissues and cell lines. these data suggest that multiple miRNAs can regulate XIAP via its 3'UTR. miR (show MLXIP Proteins)-137 can sensitise ovarian cancer cells to cisplatin-induced apoptosis, providing new insight into overcoming drug resistance in ovarian cancer

  7. results of this work support the role of XIAP in mediating NOD2 signaling while reconciling the role of X-linked lymphoproliferative syndrome 2 and very-early-onset inflammatory bowel disease XIAP mutations in inflammatory cell death and provide a set of tools and framework to rapidly test newly discovered XIAP variants.

  8. Using recombinant proteins, this study investigated the influence of survivin (show BIRC5 Proteins) on the inhibition of caspase-9 (show CASP9 Proteins) by XIAP in vitro. With a fluorescence-based assay for the apoptosome-stimulated activity of caspase-9 (show CASP9 Proteins), the study shows that survivin (show BIRC5 Proteins) has no effect on the inhibition of caspase-9 (show CASP9 Proteins) by XIAP, neither in the presence nor in the absence of Smac (show DIABLO Proteins).

  9. Study found a negative correlation between Smac (show DIABLO Proteins) and XIAP at the level of protein but not mRNA in non-small cell lung carcinoma (NSCLC) patients. Overexpressed XIAP could degrade through ubiquitination, the mature Smac (show DIABLO Proteins) inhibiting NSCLC apoptosis.

  10. Combined triple actions of the TRAIL, the IAPs inhibitor, AT406, and the c-FLIP (show CFLAR Proteins) expression inhibitor, rocaglamide (ART), markedly improve TRAIL-induced apoptotic effects in most solid cancer cell lines through the activation of an extrinsic apoptosis pathway

Mouse (Murine) X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. These results indicate that XIAP plays an important physiologic role in regulating sublethal CASP-3 (show CASP3 Proteins) activity within central neurons and thereby facilitates synaptic plasticity and memory acquisition.

  2. XIAP antagonizes the switch from TNFalpha (show TNF Proteins)-induced apoptosis to necroptosis in mouse neutrophils.

  3. Results show that XIAP binds to the C terminus of Ptch1 (show PTCH1 Proteins) and mediates the death-dependent function of Ptch1 (show PTCH1 Proteins).

  4. XIAP modulates ubiquitylation of RIP1 (show RALBP1 Proteins) and suppresses RIP3-dependent cell death and inflammasome activation in response to TNF (show TNF Proteins)-signaling in innate immune cells.

  5. XIAP deficiency selectively impaired B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10 (show BCL10 Proteins))-mediated innate responses to dectin-1 (show CLEC7A Proteins) ligands but did not affect responses to various Toll (show TLR4 Proteins)-like receptor agonists.

  6. XIAP mRNA level was also reduced in the BRE (show BRE Proteins)-depleted cells, but the level of reduction was less profound than that of the protein level. However, BRE (show BRE Proteins) could not delay protein turnover of XIAP.

  7. Identify xIAP and cIAP1 (show BIRC2 Proteins) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.

  8. XIAP-/- DRG sensory neurons degenerate more rapidly and contain more active caspase-3 (show CASP3 Proteins).

  9. XIAP ubiquitylates RIPK2 and recruits the linear ubiquitin chain assembly complex to NOD2

  10. XIAP is expressed in oligodendrocytes in vivo and in vitro. Increased XIAP expression is associated with protection against selected cell death pathways, whereas decreased expression increases oligodendroglial cell death.

XIAP Protein Profile

Protein Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Alternative names and synonyms associated with XIAP

  • X-linked inhibitor of apoptosis (XIAP)
  • X-linked inhibitor of apoptosis (xiap)
  • X-linked inhibitor of apoptosis (Xiap)
  • 1110015C02Rik protein
  • Aipa protein
  • Api3 protein
  • Birc4 protein
  • hIAP-3 protein
  • hIAP3 protein
  • IAP-3 protein
  • IAP3 protein
  • ILP-1 protein
  • ILP1 protein
  • MIHA protein
  • mXIAP protein
  • riap3 protein
  • XLP2 protein
  • xxiap protein

Protein level used designations for XIAP

X-linked inhibitor of apoptosis protein , baculoviral IAP repeat-containing 4 , baculoviral IAP-repeat containing protein 4 , Baculoviral IAP repeat-containing protein 4 , E3 ubiquitin-protein ligase XIAP , X-linked IAP , IAP-like protein , baculoviral IAP repeat-containing protein 4 , inhibitor of apoptosis protein 3 , IAP homolog A , IAP-3 , apoptosis inhibitor 3 , mIAP-3 , mIAP3 , RIAP-3 , apoptosis inhibitor protein 3

442989 Canis lupus familiaris
594971 Xenopus (Silurana) tropicalis
331 Homo sapiens
11798 Mus musculus
63879 Rattus norvegicus
733235 Xenopus laevis
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