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Browse our XIAP Proteins (XIAP)

Full name:
X-Linked Inhibitor of Apoptosis Proteins (XIAP)
On are 10 X-Linked Inhibitor of Apoptosis (XIAP) Proteins from 7 different suppliers available. Additionally we are shipping XIAP Antibodies (163) and XIAP Kits (17) and many more products for this protein. A total of 206 XIAP products are currently listed.
1110015C02Rik, Aipa, Api3, Birc4, hIAP-3, hIAP3, IAP-3, IAP3, ILP-1, ILP1, MIHA, mXIAP, riap3, XLP2, xxiap
list all proteins Gene Name GeneID UniProt
XIAP 331 P98170
Mouse XIAP XIAP 11798 Q60989
XIAP 63879 Q9R0I6

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Human X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. Overexpression of FOXM1 (show FOXM1 Proteins), XIAP, and Survivin (show BIRC5 Proteins) contributes to the development of drug-resistance and is associated with poor clinical outcome in breast cancer patients.

  2. Abnormal expression of XIAP may be an important underlying mechanism in the development of bicuspid aortic valve and renal malformations in Turner syndrome.

  3. AZD5582 draws Mcl-1 (show MCL1 Proteins) down-regulation for induction of apoptosis through targeting of cIAP1 (show BIRC2 Proteins) and XIAP in human pancreatic cancer

  4. Data indicate that Smac/DIABLO (show DIABLO Proteins) showed an inverse correlation with inhibitor of apoptosis proteins XIAP, cIAP-1 (show BIRC2 Proteins) and cIAP-2 (show BIRC3 Proteins).

  5. Tumor expression of XIAP helps to identify prostate cancer patients at risk of progression.

  6. XIAP plays a critical role in the control of cytokine-induced cell death by Sestrin2.

  7. XIAP levels increased significantly during treatment in both normal and tumour tissue in accordance with the degree of radio-chemotherapy resistance of the tissue. Disturbance of the XIAP/Smac (show DIABLO Proteins) balance may be a driver of radio-chemotherapy resistance.

  8. It was concluded that high expression of HtrA1 (show HTRA1 Proteins) could significantly reverse multidrug resistance of hepatoma cells by targeting XIAP.

  9. Data show that mitochondrial X-linked inhibitor of apoptosis protein (XIAP) entry requires apoptosis regulatory proteins Bax (show BAX Proteins) or Bak (show BAK1 Proteins) through mitochondrial permeabilization and Smac/DIABLO (show DIABLO Proteins) protein degradation.

  10. overexpression of XIAP confers cisplatin-resistance in ovarian carcinoma.

Mouse (Murine) X-Linked Inhibitor of Apoptosis (XIAP) interaction partners

  1. Results show that XIAP binds to the C terminus of Ptch1 (show PTCH1 Proteins) and mediates the death-dependent function of Ptch1 (show PTCH1 Proteins).

  2. XIAP modulates ubiquitylation of RIP1 (show RALBP1 Proteins) and suppresses RIP3-dependent cell death and inflammasome activation in response to TNF (show TNF Proteins)-signaling in innate immune cells.

  3. XIAP deficiency selectively impaired B-cell chronic lymphocytic leukemia/lymphoma 10 (BCL10 (show BCL10 Proteins))-mediated innate responses to dectin-1 (show CLEC7A Proteins) ligands but did not affect responses to various Toll (show TLR4 Proteins)-like receptor agonists.

  4. XIAP mRNA level was also reduced in the BRE (show BRE Proteins)-depleted cells, but the level of reduction was less profound than that of the protein level. However, BRE (show BRE Proteins) could not delay protein turnover of XIAP.

  5. Identify xIAP and cIAP1 (show BIRC2 Proteins) as molecular targets of ceramide and show ceramide analog LCL85 is an effective sensitizer in overcoming resistance of metastatic colon and breast cancers to apoptosis induction to suppress metastasis in vivo.

  6. XIAP-/- DRG sensory neurons degenerate more rapidly and contain more active caspase-3 (show CASP3 Proteins).

  7. XIAP ubiquitylates RIPK2 and recruits the linear ubiquitin chain assembly complex to NOD2

  8. XIAP is expressed in oligodendrocytes in vivo and in vitro. Increased XIAP expression is associated with protection against selected cell death pathways, whereas decreased expression increases oligodendroglial cell death.

  9. ARTS (Septin 4 (show SEPT4 Proteins)) promotes apoptosis mainly through binding and antagonizing XIAP.

  10. A critical role is identified for XIAP in regulating neuronal apoptosis in neonatal brain injury.

XIAP Protein Profile

Protein Summary

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

Alternative names and synonyms associated with XIAP

  • X-linked inhibitor of apoptosis (XIAP)
  • X-linked inhibitor of apoptosis (xiap)
  • X-linked inhibitor of apoptosis (Xiap)
  • 1110015C02Rik protein
  • Aipa protein
  • Api3 protein
  • Birc4 protein
  • hIAP-3 protein
  • hIAP3 protein
  • IAP-3 protein
  • IAP3 protein
  • ILP-1 protein
  • ILP1 protein
  • MIHA protein
  • mXIAP protein
  • riap3 protein
  • XLP2 protein
  • xxiap protein

Protein level used designations for XIAP

X-linked inhibitor of apoptosis protein , baculoviral IAP repeat-containing 4 , baculoviral IAP-repeat containing protein 4 , Baculoviral IAP repeat-containing protein 4 , E3 ubiquitin-protein ligase XIAP , X-linked IAP , IAP-like protein , baculoviral IAP repeat-containing protein 4 , inhibitor of apoptosis protein 3 , IAP homolog A , IAP-3 , apoptosis inhibitor 3 , mIAP-3 , mIAP3 , RIAP-3 , apoptosis inhibitor protein 3

442989 Canis lupus familiaris
594971 Xenopus (Silurana) tropicalis
331 Homo sapiens
11798 Mus musculus
63879 Rattus norvegicus
733235 Xenopus laevis
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