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Ex vivo lung perfusion with adenosine A2A receptor agonist allows prolonged cold preservation of lungs donated after cardiac death.
Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet.
Pretreatment strategy with adenosine A2A receptor agonist attenuates reperfusion injury in a preclinical porcine lung transplantation model.
mRNA for adenosine A(1), A(2A), A(2B (show ADRA2B Proteins)), and A(3) receptors was expressed in arterioles and venules. Protein for A(1), A(2A), and A(2B (show ADRA2B Proteins)), but not A(3), was detected in both microvessel types and was further demonstrated on vascular endothelial cells
Study reveals presence of adenosine A(2A) and A(2B (show ADRA2B Proteins)) receptors as well as a role for them in lacrimal gland secretion, and especially in synergy with purinergic and cholinergic stimulation.
Western blot analysis indicates that the A2A receptor is more abundant in the hippocampus of medial temporal lobe epilepsy patients compared to control individuals. Immunoreactivity against the A2A receptor predominates in astrocytes staining positively for the glial fibrillary acidic protein (show GFAP Proteins).
Results suggest that the combination of the ADORA2A rs2298383TT and MTHFR (show MTHFR Proteins) 1298AC-677CT genotypes might lead to a low risk of nodule formation in patients treated with methotrexate.
results unveil intracellular signaling pathways targeted by the A2AR, some of which might be key in modulating neutrophil functions.
Calcium modulates calmodulin-ACTN1 (show ACTN1 Proteins) interaction with and agonist-dependent internalization of the adenosine A2A receptor.
A2A AR activation on BBB endothelial cells offers a therapeutic window that can be fine-tuned for drug delivery to the brain and has potential as a CNS drug-delivery technology.
Hypoxic postconditioning attenuates apoptosis via inactivation of adenosine A2a receptor through NDRG3-Raf (show RAF1 Proteins)-ERK (show EPHB2 Proteins) pathway.
A1R signaling enhances A2AR-mediated neurodegeneration [review]
ADORA2A rs2298383 and high cumulative dose of systemic methotrexate (MTX (show MTX1 Proteins)) administration were significantly associated with MTX (show MTX1 Proteins)-related leukoencephalopathy
lipid 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC, di-6:0PC). After solubilization in DDM, DDM/CHAPS, or DHPC micelles, although A2AR was found to retain its native-like fold, its binding ability was significantly compromised compared to DDM or DDM/CHAPS with CHS. It therefore appears that although cholesterol is not needed for A2AR to retain a native-like, alpha-helical conformation
We report an investigation designed to explore alternative approaches for ranking of docking poses in the search for antagonists of the adenosine A2A receptor, an attractive target for structure-based virtual screening
Data indicate A2ARs exert minor effects in un-stressed myocardium and selectively suppress NFkappaB and JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) signalling and cardiac injury without influencing cardiac depression in endotoxemia.
The three receptor sets considered (mAChR (show CHRM3 Proteins), AR and TrkB (show NTRK2 Proteins) receptors) intervene in modulating the conditions of the competition between nerve endings.
High A2aR expression is associated with Melanoma Metastasis.
These novel findings indicate that adenosine suppresses REM (show REM1 Proteins) sleep via A2AR in the OB of rodents.
The findings suggest that disruption of the protective A2AR amplifies inflammation to accelerate glomerular damage and endogenous macrophage A2ARs are essential to protect from progressive kidney fibrosis.
this study has identified a unique role for A2aRs in regulating CD4 (show CD4 Proteins) T cell differentiation during vaccination.
these observations point to a previously unappreciated role of GS protein-coupled A2aR in regulating humoral immunity, which may be pharmacologically targeted during vaccination or pathological states in which GC-derived autoantibodies contribute to the pathology.
Results indicate that neuroprotection by caffeine in the MPTP (show PTPN2 Proteins) model of Parkinson's disease relies on the A2AR, although the specific cellular localization of these receptors remains to be determined
Diabetes resulted in an increased A2A/A2B (show ADORA2B Proteins) receptor expression in coronary arteries which resulted in enhanced A2A/A2B (show ADORA2B Proteins)-mediated increase in coronary flow observed in diabetic hearts.
Adenosine A2A receptor immunoreactivity is localized at the highest levels of the striatum and external globus pallidus.
Activation of adenosine A(2A) receptors inhibited ROS (show ROS1 Proteins) production by LPS (show IRF6 Proteins)-stimulated equine neutrophils in a cAMP-dependent manner.
This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.
adenosine A2a receptor
, adenosine receptor A2a
, adenosine receptor A2a.1
, A2a adenosine receptor
, adenosine receptor A2a-like
, adenosine receptor subtype A2a
, A2a, Rs
, Adenosine A2a-receptor