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Browse our APLP1 Proteins (APLP1)

Full name:
Amyloid beta (A4) Precursor-Like Protein 1 Proteins (APLP1)
On are 9 Amyloid beta (A4) Precursor-Like Protein 1 (APLP1) Proteins from 4 different suppliers available. Additionally we are shipping APLP1 Antibodies (59) and APLP1 Kits (9) and many more products for this protein. A total of 83 APLP1 products are currently listed.
APLP, Aplp1_retired, MGC115336, RGD1561211
list all proteins Gene Name GeneID UniProt
APLP1 333 P51693
APLP1 11803 Q03157
Rat APLP1 APLP1 502317  

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APLP1 Proteins (APLP1) by Origin

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Top referenced APLP1 Proteins

  1. Human APLP1 Protein expressed in Human Cells - ABIN2005870 : Needham, Wlodek, Ciccotosto, Fam, Masters, Proietto, Andrikopoulos, Cappai: Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth. in The Journal of pathology 2008 (PubMed)

More Proteins for APLP1 Interaction Partners

Human Amyloid beta (A4) Precursor-Like Protein 1 (APLP1) interaction partners

  1. These data reveal a conserved mechanism for the binding of APP (show APP Proteins)-family proteins to HS and imply a specific regulatory role of HS modifications in the biology of APP (show APP Proteins) and APP-like (show APP Proteins) proteins.

  2. APLP1 and APLP2 (show APLP2 Proteins), behave similarly to APP (show APP Proteins) in that they both associate with assembled NMDA receptors in the endoplasmic reticulum

  3. CSF (show CSF2 Proteins) levels of 3 endogenous peptides derived from APLP1 (APL1beta25, APL1beta27 and APL1beta28) were decreased in Down syndrome.

  4. APLP1 has a regulatory role in the nuclear translocation of APP (show APP Proteins) family intracellular domains due to the sequestration of Fe65 (show APBB1 Proteins).

  5. [review] APP (show APP Proteins) and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2 (show APLP2 Proteins), participate under physiological conditions via trans-cellular dimerization in synaptogenesis.

  6. APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel.

  7. Both APLP1 and APLP2 (show APLP2 Proteins), form transcriptionally active triple protein complexes with Mint3 (show APBA3 Proteins) and transcriptional co-activators Taz (show TAZ Proteins) andYap.

  8. Human cerebrospinal fluid contains three APLP1-derived Abeta (show APP Proteins)-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM.

  9. APLP1 and APLP2 (show APLP2 Proteins) are processed by the gamma-secretase in a Presenilin 1 (show PSEN1 Proteins)-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like (show APP Proteins) Intracellular Domain) are able to enhance Fe65 (show APBB1 Proteins)-dependent gene activation

  10. APLP1 does not undergo the same type of regulated processing as APP (show APP Proteins) and APLP2 (show APLP2 Proteins).

Mouse (Murine) Amyloid beta (A4) Precursor-Like Protein 1 (APLP1) interaction partners

  1. Results suggest that APLP1 deficiency on its own does not lead to defects in synaptic plasticity, but affects synaptic transmission and network inhibition in the dentate gyrus

  2. [review] A role of APP (show APP Proteins) and its two closely related homologues APLP1 and APLP2 (show APLP2 Proteins) has been determined in various aspects of nervous system development and function, in particular, for synapse formation and function.

  3. findings demonstrated that NB-2 (show CNTN5 Proteins) interacts with APLP and that both NB-2 (show CNTN5 Proteins) and APLP1 are localized at presynaptic sites, suggesting that NB-2 (show CNTN5 Proteins) associates with APLP1 in a cis (show CISH Proteins) manner on the presynaptic membrane

  4. Crystal structure of the E2 domain of amyloid precursor protein-like (show APP Proteins) protein 1 in complex with sucrose octasulfate.

  5. The 5' UTR of the Aplp1 gene lacks any type of CAGA (show S100A8 Proteins) box. This may explain its inability to form amyloid plaques.

  6. Cytoplasmic polyadenylation element (CPE (show CPE Proteins)) binding factor binds the small intracellular domain (ICD) of APLP1.

  7. The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App (show APP Proteins) or Aplp2 (show APLP2 Proteins).

APLP1 Protein Profile

Protein Summary

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternative names and synonyms associated with APLP1

  • amyloid beta (A4) precursor-like protein 1 (APLP1)
  • amyloid beta (A4) precursor-like protein 1 (aplp1)
  • amyloid beta (A4) precursor-like protein 1 (Aplp1)
  • APLP protein
  • Aplp1_retired protein
  • MGC115336 protein
  • RGD1561211 protein

Protein level used designations for APLP1

amyloid-like protein 1 , amyloid beta (A4) precursor-like protein 1 , amyloid-like protein 1-like , APLP-1 , amyloid precursor-like protein 1 , APLP

476478 Canis lupus familiaris
513154 Bos taurus
711258 Macaca mulatta
734469 Xenopus laevis
100060016 Equus caballus
100151735 Xenopus (Silurana) tropicalis
100392661 Callithrix jacchus
100471364 Ailuropoda melanoleuca
100016549 Monodelphis domestica
100583911 Nomascus leucogenys
100614338 Pan troglodytes
333 Homo sapiens
11803 Mus musculus
502317 Rattus norvegicus
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