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Human CXCR1 Protein expressed in Wheat germ - ABIN1350834
Bergin, Reeves, Meleady, Henry, McElvaney, Carroll, Condron, Chotirmall, Clynes, ONeill, McElvaney: ?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. in The Journal of clinical investigation 2010
Human CXCR1 Protein expressed in Wheat germ - ABIN1330036
Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014
no statistically significant association of the SNP CXCR1+777 or CXCR1-1768 with SCS (show TWIST1 Proteins) was found
Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.
The aim of this study was to demonstrate the presence of the two SNPs in the CXCR1 gene of Japanese Black cattle and examine the association between the SNPs and clinical diseases including intestinal and respiratory diseases in calves.
Association between interleukin-8 receptor-alpha (CXCR1) polymorphism and disease incidence, production, reproduction, and survival in Holstein cows.
The situation of CXCR1 polymorphisms in Chinese Holstein cattle and determine the relationship between the CXCR1 SNPs and mastitis resistance.
The results suggests the possible role of CXCR1 gene SNPs in the host response against mastitis.
CXCR1 polymorphisms influence viability and concentration of milk polymorphonuclear neutrophilic leukocytes.
The results demonstrate that CXCR1 polymorphism can influence somatic cell count and milk neutrophil viability following experimental mastitis.
In the present study no association could be detected between superoxide production by isolated bovine neutrophils during early lactation and CXCR1 gene polymorphism. IL-8 (show IL8 Proteins) showed to possess inhibitory effects on ROS (show ROS1 Proteins) generation in bovine neutrophils.
Polymorphisms in CXCR1 are significantly associated with bovine mastitis
CXCR4 (show CXCR4 Proteins) and CXCR2 (show CXCR2 Proteins) were highly expressed in a high invasive gastric cancer cell model and in gastric cancer tissues; crosstalk between CXCR4 (show CXCR4 Proteins) and CXCR2 (show CXCR2 Proteins) contributed to EMT (show ITK Proteins), migration and invasion of gastric cancer.
A unique viral protein, vCXCL1, which targets three chemokine (show CCL1 Proteins) receptors: CXCR1 and CXCR2 (show CXCR2 Proteins) expressed on neutrophils and CXCR1 and CX3CR1 (show CX3CR1 Proteins) expressed on Natural killer cells.
High expression of CXCR1 identified a subgroup of gastric cancer patients who appeared to benefit from 5-FU based adjuvant chemotherapy .
The expressions of CXCL1 (show CXCL1 Proteins) in cancer cells and CXCR2 (show CXCR2 Proteins) in stromal cells are useful prognostic factors for gastric cancer patients
CXCR2 (show CXCR2 Proteins) preferentially supports the maintenance of human pluripotent stem cell characteristics as well as facilitates ectodermal differentiation after the commitment to differentiation, and the mechanism might be associated with mTOR (show FRAP1 Proteins), beta-catenin (show CTNNB1 Proteins), and hTERT activities.
Our result showed that CXCR2 (show CXCR2 Proteins) expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 (show CXCR2 Proteins) and CXCR3 (show CXCR3 Proteins) expressions are related to poorer overall survival (P < 0.001; P < 0.001).
These data demonstrate that the CXCR2 (show CXCR2 Proteins) network and CXCL4 (show PF4 Proteins) play a role in the maintenance of normal HSC (show FUT1 Proteins)/HPC cell fates, including survival and self-renewal.
CXCR1 and CXCR2 (show CXCR2 Proteins) regulate hepatocyte exosome release. The mechanism utilized by CXCR1 remains elusive, but CXCR2 (show CXCR2 Proteins) appears to modulate Nsm activity and resultant production of ceramide to control exosome release. CXCR1 is required for packaging of enzymes into exosomes that mediate their hepatocyte proliferative effect.
TNF-alpha (show TNF Proteins) augments CXCR2 (show CXCR2 Proteins) and CXCR3 (show CXCR3 Proteins) to promote the progression of renal cell carcinoma (show MOK Proteins) leading to a poor prognosis.
Data indicate that the crystal structure of PDZ-RhoGEF PDZ domain in complex with the CXC chemokine receptor 2 (CXCR2) C-terminal PDZ binding motif.
these studies define CXCR1 as a novel, noncanonical chemokine receptor that regulates pulmonary anti-Pseudomonas host defense with broad implications for cystic fibrosis (show S100A8 Proteins), chronic obstructive pulmonary disease and other infectious lung diseases
These data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis.
in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesi
CXCR1 expression is induced in staphylococcus aureus-infected macrophages but not in control macrophages.
Pharmacologic blockade of CXCR1/2 as well as genetic deletion of NAP-2 (show PPBP Proteins) markedly reduced leukocyte shape change and intrathrombus migration.
Blockade of the CXCL1 (show CXCL1 Proteins)-CXCR1/2 axis in mice improved intrahepatic islet engraftment. The CXCR1/2-mediated pathway is a regulator of islet damage.
Upon activation by CXCL8 (show IL8 Proteins), CXCR1 predominantly couples to G protein-coupled receptor (show GPR34 Proteins) kinase (GRK)2 (show ADRBK1 Proteins) to modulate leukocyte functions.
Xiaotan Sanjie Decoction XTSJD can decrease the protein expressions of IL-8 (show IL8 Proteins) and its receptors CXCR1/CXCR2 (show CXCR2 Proteins) in tumor xenografts and gastric tissue adjacent to the tumor.
data suggest that CXCR1 does not mediate the proliferative effects of ELR+ CXC chemokines during liver regeneration after partial hepatectomy
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.
C-X-C chemokine receptor type 2
, IL-8R B
, high affinity interleukin-8 receptor B
, interleukin 8 receptor, alpha
, chemokine (C-X-C motif) receptor 1
, C-X-C chemokine receptor type 1
, IL-8 receptor type 1
, IL-8R A
, high affinity interleukin-8 receptor A
, interleukin-8 receptor type 1
, interleukin-8 receptor type A
, CXC chemokine receptor 1
, chemokine (C-X-C motif) receptor 2
, interleukin 8 receptor, beta
, chemokine (C-X-C) motif receptor 1
, chemokine (C-X-C) receptor 1
, interleukin 8 receptor alpha
, IL-8 receptor
, CXCR2 gene for IL8 receptor type B
, GRO/MGSA receptor
, IL-8 receptor type 2
, chemokine (CXC) receptor 2
, interleukin 8 receptor B
, interleukin 8 receptor type 2
, interleukin-8 receptor type B