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Browse our CXCR1 Proteins (CXCR1)

Full name:
Chemokine (C-X-C Motif) Receptor 1 Proteins (CXCR1)
On are 5 Chemokine (C-X-C Motif) Receptor 1 (CXCR1) Proteins from 3 different suppliers available. Additionally we are shipping CXCR1 Antibodies (161) and CXCR1 Kits (42) and many more products for this protein. A total of 218 CXCR1 products are currently listed.
C-C, C-C-CKR-1, CD128, CD181, CD182, CDw128a, CDw128b, CKR-1, CMKAR1, CMKAR2, CXCR-1, CXCR1, CXCR2, IL-8RA, IL8R1, IL8R2, Il8ra, IL8RB, IL8RBA
list all proteins Gene Name GeneID UniProt
CXCR1 3577 P25024
CXCR1 227288 Q810W6
Rat CXCR1 CXCR1 54258 P70612

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CXCR1 Proteins (CXCR1) by Origin

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Top referenced CXCR1 Proteins

  1. Human CXCR1 Protein expressed in Wheat germ - ABIN1330036 : Spaan, Vrieling, Wallet, Badiou, Reyes-Robles, Ohneck, Benito, de Haas, Day, Jennings, Lina, Vandenesch, van Kessel, Torres, van Strijp, Henry: The staphylococcal toxins ?-haemolysin AB and CB differentially target phagocytes by employing specific chemokine receptors. in Nature communications 2014 (PubMed)

  2. Human CXCR1 Protein expressed in Wheat germ - ABIN1350834 : Bergin, Reeves, Meleady, Henry, McElvaney, Carroll, Condron, Chotirmall, Clynes, ONeill, McElvaney: ?-1 Antitrypsin regulates human neutrophil chemotaxis induced by soluble immune complexes and IL-8. in The Journal of clinical investigation 2010 (PubMed)

More Proteins for CXCR1 Interaction Partners

Cow (Bovine) Chemokine (C-X-C Motif) Receptor 1 (CXCR1) interaction partners

  1. The results demonstrate that CXCR1 polymorphism can influence somatic cell count and milk neutrophil viability following experimental mastitis.

  2. (PCR) was used to detect the methylation status of CXCR1 CpG island, and quantitative fluorescence PCR was used to detect CXCR1 expression in bovine mammary tissue

  3. Polymorphisms in CXCR1 are significantly associated with bovine mastitis

  4. In the present study no association could be detected between superoxide production by isolated bovine neutrophils during early lactation and CXCR1 gene polymorphism. IL-8 (show IL8 Proteins) showed to possess inhibitory effects on ROS (show ROS1 Proteins) generation in bovine neutrophils.

  5. CXCR1 polymorphisms influence viability and concentration of milk polymorphonuclear neutrophilic leukocytes.

  6. The results suggests the possible role of CXCR1 gene SNPs in the host response against mastitis.

  7. The situation of CXCR1 polymorphisms in Chinese Holstein cattle and determine the relationship between the CXCR1 SNPs and mastitis resistance.

  8. Association between interleukin-8 receptor-alpha (CXCR1) polymorphism and disease incidence, production, reproduction, and survival in Holstein cows.

  9. The aim of this study was to demonstrate the presence of the two SNPs in the CXCR1 gene of Japanese Black cattle and examine the association between the SNPs and clinical diseases including intestinal and respiratory diseases in calves.

  10. Data describe the expression of IL-8, IL-1beta and their respective receptors, CXCR1 and IL-1R1 in bovine theca cells, and suggest that VEGF is associated with the IL system in theca cells in ovary.

Human Chemokine (C-X-C Motif) Receptor 1 (CXCR1) interaction partners

  1. Results identify the CXCL2 (show CXCL2 Proteins)/MIF (show AMH Proteins)-CXCR2 (show CXCR2 Proteins) axis as an important mediator in MDSC recruitment and as predictors in bladder cancer.

  2. The analysis of IL-8 (interleukin-8 (show IL8 Proteins)), CXCR1 (IL-8RA - IL-8 receptor alpha) and CXCR2 (IL-8RB (show CXCR2 Proteins) - IL-8 receptor beta) expression showed that these molecules are present not only in many different types of inflammatory and endothelial cells, but also in several tumor basaloid, transitional and even few ghost cells.

  3. Study shows that CXCR2 (show CXCR2 Proteins) signaling in the myeloid compartment is tumor promoting and required for pancreatic cancer metastasis.

  4. The usefulness of CXCR-2 (show CXCR2 Proteins) as potential tumor marker of esophageal cancer was studied.

  5. this study shows that downregulation of CD182 (show CXCR3 Proteins) after stimulation with IL-8 (show IL8 Proteins) is more pronounced in adults than in neonates, whereas fMLP (show FPR1 Proteins) induces changes in receptor expression that are of the same magnitude in neutrophils from neonates as from adults

  6. findings present that miR (show MLXIP Proteins)-940 acts as a pivotal adaptor of CXCR2 (show CXCR2 Proteins) and its transcription downregulated CXCR2 (show CXCR2 Proteins) expression to decrease HCC (show FAM126A Proteins) invasion and migration in vitro.

  7. Our findings suggest that CXCL3 (show CXCL3 Proteins) and its receptor CXCR2 (show CXCR2 Proteins) are overexpressed in prostate cancer cells, prostate epithelial cells and prostate cancer tissues, which may play multiple roles in prostate cancer progression and metastasis.

  8. Data suggest that neutrophil-activating peptide 2 (NAP-2 (show PPBP Proteins)) secreted by NK cells can bind to CXC Chemokine Receptor (show CXCR4 Proteins) 2 (CXCR2 (show CXCR2 Proteins)) on mesenchymal stem cells (MSCs) leading to stimulation of its recruitment.

  9. Study shows that CXCR1 promoted gastric cancer cell proliferation, migration and invasion.

  10. High CXCR2 (show CXCR2 Proteins) expression is associated with pancreatic cancer.

Mouse (Murine) Chemokine (C-X-C Motif) Receptor 1 (CXCR1) interaction partners

  1. These data demonstrate a biological function for mouse Cxcr1 in vivo and indicate that CXCR1-dependent neutrophil effector function is a critical innate protective mechanism of fungal clearance and host survival in systemic candidiasis.

  2. in view of recently-published experimental data obtained in NOD mice, we argue for possible Cxcr1 involvement in type 1 diabetes pathogenesi

  3. CXCR1 expression is induced in staphylococcus aureus-infected macrophages but not in control macrophages.

  4. Pharmacologic blockade of CXCR1/2 as well as genetic deletion of NAP-2 (show PPBP Proteins) markedly reduced leukocyte shape change and intrathrombus migration.

  5. Blockade of the CXCL1 (show CXCL1 Proteins)-CXCR1/2 axis in mice improved intrahepatic islet engraftment. The CXCR1/2-mediated pathway is a regulator of islet damage.

  6. Upon activation by CXCL8 (show IL8 Proteins), CXCR1 predominantly couples to G protein-coupled receptor (show GPR34 Proteins) kinase (GRK)2 (show ADRBK1 Proteins) to modulate leukocyte functions.

  7. Xiaotan Sanjie Decoction XTSJD can decrease the protein expressions of IL-8 (show IL8 Proteins) and its receptors CXCR1/CXCR2 (show CXCR2 Proteins) in tumor xenografts and gastric tissue adjacent to the tumor.

  8. data suggest that CXCR1 does not mediate the proliferative effects of ELR+ CXC chemokines during liver regeneration after partial hepatectomy

  9. CXCR1 expression is induced in hepatocytes after injury. Furthermore, the data suggest that CXCR1 has divergent effects from CXCR2 (show CXCR2 Proteins) and appears to facilitate repair and regenerative responses after I/R injury.

  10. CX3CL1 (show CX3CL1 Proteins)-CX3CR1 (show CX3CR1 Proteins) axis can regulate the expression of iNOS (show NOS2 Proteins), a crucial mediator of DSS (show PMP22 Proteins)-induced colitis.

CXCR1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified.

Alternative names and synonyms associated with CXCR1

  • interleukin 8 receptor, beta (CXCR2)
  • interleukin 8 receptor, alpha (IL8RA)
  • chemokine (C-X-C motif) receptor 1 (CXCR1)
  • chemokine (C-X-C motif) receptor 1 (Cxcr1)
  • chemokine (C-X-C motif) receptor 2 (CXCR2)
  • C-C protein
  • C-C-CKR-1 protein
  • CD128 protein
  • CD181 protein
  • CD182 protein
  • CDw128a protein
  • CDw128b protein
  • CKR-1 protein
  • CMKAR1 protein
  • CMKAR2 protein
  • CXCR-1 protein
  • CXCR1 protein
  • CXCR2 protein
  • IL-8RA protein
  • IL8R1 protein
  • IL8R2 protein
  • Il8ra protein
  • IL8RB protein
  • IL8RBA protein

Protein level used designations for CXCR1

C-X-C chemokine receptor type 2 , CXC-R2 , CXCR-2 , IL-8R B , high affinity interleukin-8 receptor B , interleukin 8 receptor, alpha , chemokine (C-X-C motif) receptor 1 , C-X-C chemokine receptor type 1 , CXC-R1 , CXCR-1 , IL-8 receptor type 1 , IL-8R A , high affinity interleukin-8 receptor A , interleukin-8 receptor type 1 , interleukin-8 receptor type A , CXC chemokine receptor 1 , chemokine (C-X-C motif) receptor 2 , interleukin 8 receptor, beta , chemokine (C-X-C) motif receptor 1 , chemokine (C-X-C) receptor 1 , interleukin 8 receptor alpha , IL-8 receptor , CXCR2 gene for IL8 receptor type B , GRO/MGSA receptor , IL-8 receptor type 2 , chemokine (CXC) receptor 2 , interleukin 8 receptor B , interleukin 8 receptor type 2 , interleukin-8 receptor type B

281863 Bos taurus
100127487 Sus scrofa
3577 Homo sapiens
227288 Mus musculus
478906 Canis lupus familiaris
100125580 Bos taurus
54258 Rattus norvegicus
100328622 Oryctolagus cuniculus
100461947 Pongo abelii
692074 Macaca mulatta
470645 Pan troglodytes
3579 Homo sapiens
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