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Authors examined the possible association between DRD4 allelic variation and three measures of juvenile behavior. Five different DRD4 alleles (5R, 5.5R, 6R, 6.5R, and 7R) were identified in the subject population.
Many children who carry the 7R allele of DRD4 appear to be more in fl uenced by maternal sensitivity asit relates to overweight/obesity risk.
Parenting and DRD4 variants GxE interaction in ADHD.
We found statistically significant DNA hypomethylation of the promoter regions of DRD3 (show DRD3 Proteins) (P = 0.032), DRD4 (P = 0.05), MB-COMT (show COMT Proteins) (P = 0.009), and AKT1 (show AKT1 Proteins) (P = 0.0008) associated with increased expression of the corresponding genes in patients with methamphetamine psychosis (P = 0.022, P = 0.034, P = 0.035, P = 0.038, respectively)
Higher levels of antenatal maternal anxiety symptoms are associated with more frequent fetal movements among fetuses carrying a 7R allele, but not among fetuses carrying shorter DRD4 alleles.
youth without the DRD4-7R allele were particularly affected by the school environment.
Infants carrying the DRD4 7R allele showed greater effects of maternal insensitivity than non-carriers for behavioral problems at 18-months.
DRD4 exon 3 VNTR polymorphism is related to attention-deficit/ hyperactivity disorder in Chinese children.
Adolescent rule-breaking is stronger for DRD4 non-long carriers.
these findings suggest that in part genetically determined peer selection (carriers of the DRD4 seven-repeat allele tend to associate with peers who have more favorable attitudes toward drinking and greater alcohol use) and peer socialization (carriers' subsequent drinking behaviors are more strongly associated with their peer drinking norms) may differ across adolescent developmental stages.
Results found that frequency of those carrying the DRD4 7 repeat allele continuously increased with age in a Caucasian population of Hungarians until age 75, and this was found preferentially for females. For the older groups, a decrease in 7 repeat carriers was noted which might be a result of a gene environment interaction.
The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization.
This study demonstrated that dopamine D4 receptor gene has an important role in increased exploratory and anxiolytic behavior only in males and these behaviors were positively correlated with increased alcohol consumption.
Contrast sensitivity is reduced in Drd4-/- mice.
dopaminergic modulation of early long-term potentiation in stratum oriens occurs through NMDA receptors containing NR2B (show GRIN2B Proteins) subunits via D4Rs
Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 (show ADCY1 Proteins) from transcript to enzyme activity.
This study demonistrated that the dopamine D4 receptor is the role of attention.
The result of this study demonistrated that the dopamine drd4 receptor appears to be important for specific exploration.
no connection between analysed polymorphism of genes: DRD2 (show DRD2 Proteins), DRD3 (show DRD3 Proteins), DRD4, DAT (show SLC6A3 Proteins), COMT (show COMT Proteins) and schizophrenia was stated.
This result suggests an effect of 5-HTTLPR (show SLC6A4 Proteins) on externalizing behavior in the presence of DRD4 7r but no effect in its absence.
D4R signaling is essential for the expression of juvenile hyperactivity and impaired behavioral inhibition, relevant features present in this attention deficit disorder-like mouse model.
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats\; the sequence shown contains four repeats.
dopamine D4b receptor
, dopamine receptor D4
, D(2C) dopamine receptor
, D(4) dopamine receptor
, dopamine D4 receptor
, seven transmembrane helix receptor
, d(2C) dopamine receptor
, dopamine receptor 4