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Authors examined the possible association between DRD4 allelic variation and three measures of juvenile behavior. Five different DRD4 alleles (5R, 5.5R, 6R, 6.5R, and 7R) were identified in the subject population.
GxE interaction between DRD4 7R and family SES/neighborhood poverty, and the frequency of voluntary and involuntary job changes through educational achievement.
the results of the present study demonstrated that elevated DRD4 promoter methylation was associated with AD risk in males.
p44 (show GTF2H2 Proteins)/42 MAPK (show MAPK1 Proteins) phosphorylation, the signaling pathway which is often regulated by beta-arrestins is not influenced by KLHL12 (show KLHL12 Proteins), but seems to be exclusively mediated by Galphai protein upon dopamine D4 receptor stimulation.
The results indicate that epigenetic regulation of the DRD4 gene in the form of increased methylation is associated with the cognitive/attentional deficits in ADHD.
DRD4 antagonist has an antimelanogenic effect that is related to downregulation of MITF (show MITF Proteins) transcription through the activation of the ERK (show EPHB2 Proteins)
DRD4 7-repeat carriers with ADHD showed the least striatal activation during reward anticipation when exposed to high maternal warmth, but the most when exposed to low warmth.
DRD4 gene expression reduction in breast cancer patients after spiritual intervention
Polymorphisms of the DRD4 gene appear to be associated with SSRI treatment response in Chinese MDD patients.
Findings provide evidence of an epistatic interaction between polymorphisms acting within the dopamine system (specifically upon DRD4 and COMT (show COMT Proteins) activity) and likelihood of comorbid substance abuse in women with bulimia-spectrum eating disturbances
Community disadvantage interacted with parental DRD4 status to predict low levels of protective parenting. Protective parenting, in turn, interacted with youth DRD4 status to forecast increases in youth's planful future orientations, a proximal influence on changes in risk behavior.
The G-protein coupled receptor, DRD4, requires ARR1 and ARR4 for desensitization and internalization.
This study demonstrated that dopamine D4 receptor gene has an important role in increased exploratory and anxiolytic behavior only in males and these behaviors were positively correlated with increased alcohol consumption.
Contrast sensitivity is reduced in Drd4-/- mice.
dopaminergic modulation of early long-term potentiation in stratum oriens occurs through NMDA receptors containing NR2B (show GRIN2B Proteins) subunits via D4Rs
Data demonstrate that stimulating the dopamine Dreceptor is essential in maintaining the normal rhythmic production of adenylyl cyclase 1 (show ADCY1 Proteins) from transcript to enzyme activity.
This study demonistrated that the dopamine D4 receptor is the role of attention.
The result of this study demonistrated that the dopamine drd4 receptor appears to be important for specific exploration.
no connection between analysed polymorphism of genes: DRD2 (show DRD2 Proteins), DRD3 (show DRD3 Proteins), DRD4, DAT (show SLC6A3 Proteins), COMT (show COMT Proteins) and schizophrenia was stated.
This result suggests an effect of 5-HTTLPR (show SLC6A4 Proteins) on externalizing behavior in the presence of DRD4 7r but no effect in its absence.
D4R signaling is essential for the expression of juvenile hyperactivity and impaired behavioral inhibition, relevant features present in this attention deficit disorder-like mouse model.
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats\; the sequence shown contains four repeats.
dopamine D4b receptor
, dopamine receptor D4
, D(2C) dopamine receptor
, D(4) dopamine receptor
, dopamine D4 receptor
, seven transmembrane helix receptor
, d(2C) dopamine receptor
, dopamine receptor 4