Browse our Egl Nine Homolog 1 (C. Elegans) Proteins (EGLN1)

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Egl Nine Homolog 1 (C. Elegans) Proteins (EGLN1)
On are 6 Egl Nine Homolog 1 (C. Elegans) (EGLN1) Proteins from 4 different suppliers available. Additionally we are shipping Egl Nine Homolog 1 (C. Elegans) Antibodies (156) and Egl Nine Homolog 1 (C. Elegans) Kits (8) and many more products for this protein. A total of 173 Egl Nine Homolog 1 (C. Elegans) products are currently listed.
AI503754, C1orf12, ECYT3, EGLN1, egln2, Hif-p4h-2, HIF-PH2, HIFPH2, HPH-2, HPH2, ORF13, PHD-2, PHD2, SM-20, SM20, zgc:92314, ZMYND6
list all proteins Gene Name GeneID UniProt
EGLN1 112405 Q91YE3
EGLN1 308913  
EGLN1 54583 Q9GZT9

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Egl Nine Homolog 1 (C. Elegans) Proteins (EGLN1) by Origin

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More Proteins for Egl Nine Homolog 1 (C. Elegans) Interaction Partners

Xenopus laevis Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. oxygen via Phd2 has a decisive influence on the formation of the vascular network during vertebrate embryogenesis.

  2. comparative analysis of phd1 (show EGLN2 Proteins), 2, and 3 expression in Xenopus laevis

Mouse (Murine) Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. Epo (show EPO Proteins) transcription in brain pericytes was HIF-2 dependent and cocontrolled by PHD2 and PHD3 (show EGLN3 Proteins), oxygen- and 2-oxoglutarate-dependent prolyl-4-hydroxylases that regulate HIF activity.

  2. Notch ligand (show JAG2 Proteins) genes Jag1 (show JAG1 Proteins), Jag2 (show JAG2 Proteins), and Dll1 (show DLL1 Proteins) and target Hes1 became downregulated upon aging HIF-2alpha (show EPAS1 Proteins) dependently.

  3. Results identified a critical role of PHD2 for a reversible glycolytic reprogramming in macrophages with a direct impact on their function.

  4. Results found that loss of endothelial PHD2 induced pulmonary arterial hypertension and vascular remodeling in a HIF-2-dependent fashion.

  5. We conclude that the activation of the HIF pathway induced by PHD2 deficiency enhances the effect of running training

  6. deleting Phd1 (show EGLN2 Proteins)-3 genes in osteoblasts increased osteoclast formation in vitro and in bone.

  7. Key messages: HIF-P4H-2 deficiency protects skeletal muscle from ischemia-reperfusion injury. The mechanisms involved are mediated via normoxic HIF-1alpha (show HIF1A Proteins) and HIF-2alpha (show EPAS1 Proteins) stabilization. HIF-P4H-2 deficiency increases capillary size but not number. HIF-P4H-2 deficiency maintains energy metabolism during ischemia-reperfusion.

  8. Diminished degradation of FLNA upon PHD2 inactivation in hypoxia rearranges the actin cytoskeleton to reduce the number of dendritic spines, synapses.

  9. Stabilized HIF-1alpha (show HIF1A Proteins) induced by PHD2 conditional knockout resulted in the transition of muscle fibers toward a slow fiber type via a calcineurin (show PPP3CA Proteins)/NFATc1 (show NFATC1 Proteins) signaling pathway.

  10. HIF-P4H-2 inhibition may be a novel strategy for protecting against the development of atherosclerosis.

Human Egl Nine Homolog 1 (C. Elegans) (EGLN1) interaction partners

  1. Genetic variants in HIF-1alpha (show HIF1A Proteins) and PHD2 genes exist in Caucasians but do not appear to alter 30-day mortality in sepsis

  2. Results identified a critical role of PHD2 for a reversible glycolytic reprogramming in macrophages with a direct impact on their function.

  3. The role of PHD-2 in breast cancer [review]

  4. Sulfur mustard negatively affects hypoxia-stimulated HIF-1alpha (show HIF1A Proteins) signaling in keratinocytes and fibroblasts and thus possibly contributes to delayed wound healing in SM-injured patients, which could be treated with PHD-2 inhibitors.

  5. The HIFalpha subunit is usually prolyl-hydroxylated by EglN family members under normoxic conditions, causing its rapid degradation. Study confirmed that triple-negative breast cancer cells secrete glutamate (show GRIN1 Proteins), which is both necessary and sufficient for the paracrine induction of HIF1alpha (show HIF1A Proteins) in such cells under normoxic conditions.

  6. Disulfide bond-mediated PHD2 dimerization and inactivation result in the activation of HIF-1alpha (show HIF1A Proteins) and aerobic glycolysis in response to oxidative stress.

  7. The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2/HIF-1alpha (show HIF1A Proteins) signaling pathway.

  8. the levels of both miR-182 and HIF1alpha were elevated, while the expression PHD2 and FIH1 was downregulated in a mouse model of prostate cancer.

  9. findings show hypoxia and loss of PHD2 revert cancer-associated fibroblast (CAF (show KAT2B Proteins)) activation

  10. In this article, UTMD/PEI mediated gene transfection was investigated and the US parameters were optimized. Furthermore, the biological effects of PHD2 shRNA were investigated in H9C2 cells.

Egl Nine Homolog 1 (C. Elegans) (EGLN1) Protein Profile

Protein Summary

The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3).

Alternative names and synonyms associated with Egl Nine Homolog 1 (C. Elegans) (EGLN1)

  • egl nine homolog 1 (C. elegans) (EGLN1)
  • egl nine homolog 1 (egln1)
  • egl nine homolog 1 (C. elegans) (egln1)
  • EGL nine homolog 1 (C. elegans) (Egln1)
  • egl-9 family hypoxia-inducible factor 1 (EGLN1)
  • AI503754 protein
  • C1orf12 protein
  • ECYT3 protein
  • EGLN1 protein
  • egln2 protein
  • Hif-p4h-2 protein
  • HIF-PH2 protein
  • HIFPH2 protein
  • HPH-2 protein
  • HPH2 protein
  • ORF13 protein
  • PHD-2 protein
  • PHD2 protein
  • SM-20 protein
  • SM20 protein
  • zgc:92314 protein
  • ZMYND6 protein

Protein level used designations for EGLN1

egl nine homolog 1 (C. elegans) , egl nine homolog 1 , egl nine homolog 1-like , egl nine homolog 2 , Hif-p4h-2 , HIF-prolyl hydroxylase 2 , hypoxia-inducible factor prolyl hydroxylase 2 , prolyl hydroxylase domain-containing protein 2 , HIF prolyl hydroxylase 2 , egl nine-like protein 1 , zinc finger MYND domain-containing protein 6

421528 Gallus gallus
469708 Pan troglodytes
534075 Bos taurus
100153461 Sus scrofa
100454843 Pongo abelii
100594374 Nomascus leucogenys
446395 Xenopus laevis
436868 Danio rerio
488971 Canis lupus familiaris
112405 Mus musculus
308913 Rattus norvegicus
54583 Homo sapiens
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