Browse our Endothelin-1 Receptor Proteins (EDNRA)

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Endothelin Receptor Type A Proteins (EDNRA)
On are 13 Endothelin Receptor Type A (EDNRA) Proteins from 3 different suppliers available. Additionally we are shipping Endothelin-1 Receptor Antibodies (80) and Endothelin-1 Receptor Kits (32) and many more products for this protein. A total of 130 Endothelin-1 Receptor products are currently listed.
2AR, Apl-1, BNSP, Bsp, BSPI, ednr-a, ednra, ednraa, Endor, ET-A, ET-AR, ETa, ETA-1, ETA-R, ETAR, ETRA, Gpcr10, hET-AR, OP, Opn, Opnl, RGD1559432, Ric, Spp-1, wu:fb75g12
list all proteins Gene Name GeneID UniProt
EDNRA 1909 P25101
Rat EDNRA EDNRA 24326 P26684
EDNRA 13617 Q61614

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Endothelin-1 Receptor Proteins (EDNRA) by Origin

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More Proteins for Endothelin-1 Receptor Interaction Partners

Horse (Equine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses.

  2. both endothelin A and endothelin B receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins.

Zebrafish Endothelin Receptor Type A (EDNRA) interaction partners

  1. Data suggest that edn1 (show EDN1 Proteins)/ednraa (endothelin-1/endothelin-1 (show EDN1 Proteins) receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.

  2. Edn1 (show EDN1 Proteins) from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.

Xenopus laevis Endothelin Receptor Type A (EDNRA) interaction partners

  1. A new role for ednra signaling during early neural crest specification is reported.

Human Endothelin Receptor Type A (EDNRA) interaction partners

  1. ETAR stimulation acted via downstream G-protein Galphaq (show GNAQ Proteins)/11 and Rho GTPase (show RACGAP1 Proteins) to suppress the Hippo pathway, thus leading to YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) activation, which was required for ETAR-induced tumorigenesis. Overall, these results indicate a critical role of the YAP (show YAP1 Proteins)/TAZ (show TAZ Proteins) axis in ETAR signaling

  2. Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (show ARRB1 Proteins) (beta-arr1 (show ARRB1 Proteins)) with Rho guanine nucleotide exchange factor (GEF) 11 (show ARHGEF11 Proteins) protein (PDZ-RhoGEF (show ARHGEF11 Proteins)).

  3. In control arteries, ETAR was expressed by vascular smooth muscle cells in the media whereas ETBR (show EDNRB Proteins) was hardly detected. In giant cell arteritis, both ETAR and ETBR (show EDNRB Proteins) receptors were expressed by alphaSMA (show ACTA2 Proteins)-positive cells at the intima-media border. Endothelial cells and inflammatory cells also expressed both ET receptors.

  4. Increased circulating Edn1 (show EDN1 Proteins) and expression of Ednra in endothelial cells are characteristic of diabetic kidney disease.

  5. Data suggest that TNFalpha (tumor necrosis factor-alpha (show TNF Proteins)) induces proliferation of airway smooth muscle cells via ET1 (endothelin-1 (show EDN1 Proteins)), GM-CSF (granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins)), and IL6 (interleukin 6 (show IL6 Proteins)) signaling; ET1 (show EDN1 Proteins) induces cell proliferation via ETAR (endothelin receptor type A); ETBR (endothelin receptor type B (show EDNRB Proteins)) is up-regulated by TNFalpha (show TNF Proteins) and appears to mediate ET1 (show EDN1 Proteins) effects on cell proliferation.

  6. presence of ET-1 (show EDN1 Proteins) receptors in the chronic thrombus in proximal CTEPH suggests ET-1 (show EDN1 Proteins) could act not only on the distal vasculopathy in the unobstructed vessels but may also stimulate smooth muscle cell proliferation within chronic clot (show TXNDC17 Proteins)

  7. Data show that auriculo-condylar syndrome (ACS (show PLA2G15 Proteins))-associated mutations in G protein subunit alpha i3 (GNAI3 (show GNAI3 Proteins)) produce dominant-negative Galpha (show SUCLG1 Proteins)(i3) mutant proteins that couple to endothelin type A receptor (ET(A)R).

  8. Patients with lung fibrosis and patients with high modified Rodnan skin score showed a reduced endothelin 1 (show EDN1 Proteins) Type A receptor (ETAR)/ETBR (show EDNRB Proteins) ratio.

  9. High ETAR expression is associated with ovarian carcinoma.

  10. Data show that macitentan interferes with the profibrotic action of transforming growth factor-beta (TGF-beta), blocking the endothelin receptor type A (ET-1 (show EDN1 Proteins) receptor) portion of the ET-1 (show EDN1 Proteins)/TGF-beta (show TGFB1 Proteins) receptor complex.

Mouse (Murine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Findings demonstrate that claudin-low mammary tumor cells rely on OPN (show SPP1 Proteins) for proliferation, survival and migration as knockdown of OPN (show SPP1 Proteins) using siRNA inhibited proliferation and migration while increasing apoptosis.

  2. endothelin A receptor activation on mesangial cells is a key event in initiation of Alport glomerular disease in this mouse model.

  3. TSC1 (show TSC1 Proteins)/TSC2 complex upregulation of OPN (show SPP1 Proteins) expression is mediated by transcription factor SOX9 (show SOX9 Proteins) in an mTOR (show FRAP1 Proteins)-independent manner. Moreover, ablation of OPN (show SPP1 Proteins) by deficient TSC1 (show TSC1 Proteins)/TSC2 complex contributed to inactivation of AKT (show AKT1 Proteins) in TSC (show SLC12A3 Proteins) cells

  4. Intracellular OPN (show SPP1 Proteins) (iOPN) diminished the population size of myeloid progenitor cells and myeloid cells, and secreted OPN (show SPP1 Proteins) (sOPN) increase the population size of lymphoid cells. The total effect of OPN (show SPP1 Proteins) on skewing the leukocyte population balance was observed as host sensitivity to early systemic infection with Candida albicans and T cell-mediated colitis.

  5. this study shows that OPN (show SPP1 Proteins) promotes sepsis in Pseudomonas aeruginosa-infected mice and potentially blocks B cell-dependent immunity

  6. observed a marked decrease of renal gene expression and urinary excretion of osteopontin (show SPP1 Proteins) in Npt2a (show SLC34A1 Proteins)(-/-) mice

  7. data suggest the possibility that Opn (show SPP1 Proteins) might regulate the homeostasis of intestinal microflora through maintenance of TCRgammadelta+ IELs, possibly by support of IEL survival

  8. OPN (show SPP1 Proteins) secreted by follicular CD153 (show TNFSF8 Proteins)(+) senescence-associated T cells in germinal centers (GCs (show UGCG Proteins)) promotes a continuous supply of intracellular autoantigens via apoptotic cells, thus playing a key role in the progression of the autoreactive GC reaction and leading to pathogenic autoantibody production in lupus-prone mice.

  9. study demonstrated an anti-tumorigenic role of OPN (show SPP1 Proteins) in transgenic adenocarcinoma of the mouse prostate (TRAMP (show DPT Proteins)) development and also suggests that the contribution of OPN (show SPP1 Proteins) to tumor development depends on the type of tumor as well as the source and isoform of OPN (show SPP1 Proteins)

  10. These data suggest a critical role for reduced stroma-derived osteopontin for hematopoietic stem cell aging.

Pig (Porcine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Proteins) receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.

  3. Blocking ET(A) and ET(B (show EDNRB Proteins)) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP (show CD47 Proteins)).

  4. Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction.

  5. study suggests a possible role for endothelin-1 (show EDN1 Proteins)(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig

  6. Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion.

  7. Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics.

  8. ET(A) blockade had no effect on pulmonary vascular resistance at rest or during exercise.

  9. PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries

Cow (Bovine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Data suggest that, in Fallopian tubes, endothelins (EDN1 (show EDN1 Proteins), EDN2 (show EDN2 Proteins), EDN3 (show EDN3 Proteins)) and EDN (show RNASE2 Proteins)-converting enzymes (ECE1 (show ECE1 Proteins), ECE2 (show ECE2 Proteins)) are expressed in epithelial cells; EDN (show RNASE2 Proteins) receptors (EDNRA, EDNRB (show EDNRB Proteins)) are present in smooth-muscle. Expression of EDN1 (show EDN1 Proteins), EDN2 (show EDN2 Proteins), and ECE2 (show ECE2 Proteins) is highest on day of ovulation. EDN (show RNASE2 Proteins)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.

  2. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  3. Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

Endothelin-1 Receptor (EDNRA) Protein Profile

Protein Summary

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Endothelin-1 Receptor (EDNRA)

  • endothelin receptor type A (EDNRA)
  • endothelin receptor type Aa (ednraa)
  • endothelin receptor type A (ednra-a)
  • endothelin receptor type A (ednra)
  • endothelin receptor type A (etr)
  • endothelin receptor type A (Ednra)
  • secreted phosphoprotein 1 (Spp1)
  • 2AR protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSPI protein
  • ednr-a protein
  • ednra protein
  • ednraa protein
  • Endor protein
  • ET-A protein
  • ET-AR protein
  • ETa protein
  • ETA-1 protein
  • ETA-R protein
  • ETAR protein
  • ETRA protein
  • Gpcr10 protein
  • hET-AR protein
  • OP protein
  • Opn protein
  • Opnl protein
  • RGD1559432 protein
  • Ric protein
  • Spp-1 protein
  • wu:fb75g12 protein

Protein level used designations for EDNRA

endothelin-1 receptor , Ednra2 , endothelin receptor A , endothelin receptor type A , endothelin type-A receptor 2 , etID40953.1 , Endothelin-1 receptor type A , endothelin receptor type A a , G protein-coupled receptor , endothelin receptor subtype A , endothelin-1-specific receptor , endothelin A receptor , ET-A , G-protein coupled receptor 10 , ET-AR , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

100062644 Equus caballus
114550 Danio rerio
380342 Xenopus laevis
779728 Xenopus (Silurana) tropicalis
100049646 Takifugu rubripes
1909 Homo sapiens
24326 Rattus norvegicus
13617 Mus musculus
373908 Gallus gallus
450187 Canis lupus familiaris
397457 Sus scrofa
281749 Bos taurus
443465 Ovis aries
20750 Mus musculus
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