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Browse our Endothelin-1 Receptor Proteins (EDNRA)

Full name:
Endothelin Receptor Type A Proteins (EDNRA)
On are 14 Endothelin Receptor Type A (EDNRA) Proteins from 4 different suppliers available. Additionally we are shipping Endothelin-1 Receptor Antibodies (76) and Endothelin-1 Receptor Kits (11) and many more products for this protein. A total of 106 Endothelin-1 Receptor products are currently listed.
2AR, Apl-1, BNSP, Bsp, BSPI, ednr-a, ednra, ednraa, Endor, ET-A, ET-AR, ETa, ETA-1, ETA-R, ETAR, ETRA, Gpcr10, hET-AR, OP, Opn, Opnl, RGD1559432, Ric, Spp-1, wu:fb75g12
list all proteins Gene Name GeneID UniProt
EDNRA 1909 P25101
Rat EDNRA EDNRA 24326 P26684
EDNRA 13617 Q61614

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Endothelin-1 Receptor Proteins (EDNRA) by Origin

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More Proteins for Endothelin-1 Receptor Interaction Partners

Horse (Equine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Hyperinsulinemia caused significant changes in endothelin receptor expression, which suggested that ETR antagonists might be beneficial for treatment of laminitis in horses.

  2. both endothelin A and endothelin B receptors are involved in the net tonic response to ET-1 (show EDN1 Proteins) in normal laminar veins.

Zebrafish Endothelin Receptor Type A (EDNRA) interaction partners

  1. Data suggest that edn1 (show EDN1 Proteins)/ednraa (endothelin-1/endothelin-1 (show EDN1 Proteins) receptor type A) signaling is involved in acid-base regulation and transepithelial proton secretion via vacuolar proton-translocating ATPase in zebrafish embryonic skin.

  2. Edn1 (show EDN1 Proteins) from the pharyngeal ectoderm signals through Ednra proteins to direct early dorsoventral patterning of the skeletogenic neural crest.

Xenopus laevis Endothelin Receptor Type A (EDNRA) interaction partners

  1. A new role for ednra signaling during early neural crest specification is reported.

Human Endothelin Receptor Type A (EDNRA) interaction partners

  1. presence of ET-1 (show EDN1 Proteins) receptors in the chronic thrombus in proximal CTEPH suggests ET-1 (show EDN1 Proteins) could act not only on the distal vasculopathy in the unobstructed vessels but may also stimulate smooth muscle cell proliferation within chronic clot (show TXNDC17 Proteins)

  2. Data show that auriculo-condylar syndrome (ACS (show PLA2G15 Proteins))-associated mutations in G protein subunit alpha i3 (GNAI3 (show GNAI3 Proteins)) produce dominant-negative Galpha (show SUCLG1 Proteins)(i3) mutant proteins that couple to endothelin type A receptor (ET(A)R).

  3. Patients with lung fibrosis and patients with high modified Rodnan skin score showed a reduced endothelin 1 (show EDN1 Proteins) Type A receptor (ETAR)/ETBR (show EDNRB Proteins) ratio.

  4. High ETAR expression is associated with ovarian carcinoma.

  5. Data show that macitentan interferes with the profibrotic action of transforming growth factor-beta (TGF-beta), blocking the endothelin receptor type A (ET-1 (show EDN1 Proteins) receptor) portion of the ET-1 (show EDN1 Proteins)/TGF-beta (show TGFB1 Proteins) receptor complex.

  6. Ednra, encoding Endothelin receptor A (ETA)-the target of Endothelin 1 (ET-1 (show EDN1 Proteins))-was significantly increased in Systemic Capillary Leak Syndrome blood-outgrowth endothelial cells compared to healthy controls.

  7. role of ET-1 (show EDN1 Proteins)/ETR-A signalling in Gd-induced fibrosis and calcification in nephrogenic systemic fibrosis

  8. Plasma proET-1 levels increase in CKD and may be useful biomarkers of renal injury. Increases in response to endothelin A antagonism may reflect EDN1 (show EDN1 Proteins) upregulation, which may partly explain fluid retention with these agents.

  9. Genebased analyses revealed associations of the EDNRA gene with longitudinal Blood Pressure phenotypes, associations with essential hypertension, Blood Pressure salt sensitivity, preeclampsia, or preclinical stages of atherosclerosis.

  10. Endothelin receptor A was detected in all patients with squamous cell carcinoma and psoriasis, with a higher frequency and grade of expression than controls and basal cell carcinoma.

Mouse (Murine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Endothelin A receptor may be involved in paraquat-induced toxic myocardial contractile anomalies possibly related to apoptosis and mitochondrial damage.

  2. OPN (show SPP1 Proteins) induces oxidative stress via the involvement of mitochondria and NOX-4 (show NOX4 Proteins). It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK (show BIK Proteins).

  3. Endogenous osteopontin (show SPP1 Proteins) plays a critical role in the prevention of phosphate-induced nephrocalcinosis and vascular calcification in response to high phosphate load.

  4. GATA4 (show GATA4 Proteins) acts as a negative regulator of Bsp (show KLK6 Proteins) expression in osteoblasts.

  5. Genetic deletion of osteopontin (show SPP1 Proteins) in TRAMP (show DPT Proteins) mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers.

  6. IFN-gamma (show IFNG Proteins) regulates hypertensive vascular collagen remodeling induced by ANG II (show AGT Proteins) and inhibits the differentiation of Th17 cells by suppressing OPN (show SPP1 Proteins) expression and regulating secretion of inflammatory cytokines.

  7. results indicate that autocrine OPN (show SPP1 Proteins) plays a crucial role in HPC expansion, migration, and subsequent oncogenic transformation of HPCs, which may provide a new insight into hepatocarcinogenesis

  8. OPN (show SPP1 Proteins) produced by hematogenous macrophages induces astrocyte process extension toward the infarct border zone, which may contribute to repair of the ischemic neurovascular unit following stroke

  9. ETAR-positive macrophages highly accumulated in the inflamed liver of mutant p53 (show TP53 Proteins)(R172) plus IL27RA (show IL27RA Proteins)(-/-)

  10. During the priming phase of liver regeneration, osteopontin (show SPP1 Proteins) enhances the recruitment of macrophages and neutrophils, and triggers hepatocyte proliferation through Kupffer cell-derived IL-6 (show IL6 Proteins) release and the downstream activation of Stat3 (show STAT3 Proteins).

Pig (Porcine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. sub-vasomotor concentration of ET-1 (show EDN1 Proteins) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (show MAPK14 Proteins) kinase-mediated production of superoxide from NADPH oxidase (show NOX1 Proteins) following ETA receptor activation

  2. PDE5 (show PDE5A Proteins) inhibition and increase in cGMP produce pulmonary vasodilation that is mediated in part through inhibition of the ET pathway, thereby precluding an additional vasodilator effect of ETA/ETB (show EDNRB Proteins) receptor blockade in the presence of PDE5 (show PDE5A Proteins) inhibition.

  3. Blocking ET(A) and ET(B (show EDNRB Proteins)) receptors partially protects sinusoidal circulation and tissue oxygenation against stress induced by high intra-abdominal pressure (IAP (show CD47 Proteins)).

  4. Anti-endothelin receptor A therapy accelerated the reversal of flow-induced pulmonary arterial disease after flow correction.

  5. study suggests a possible role for endothelin-1 (show EDN1 Proteins)(resulting from the actions of endothelin-converting enzyme-1 (show ECE1 Proteins)) acting via endothelin receptor A in the control of luteolytic sensitivity in the pig

  6. Endothelin-A receptor antagonist alters the expression of vasoactive genes and proinflammatory cytokines during hepatic ischemic/reperfusion.

  7. Report that inhalation of the endothelin-A receptor antagonist LU-135252 at various doses in experimental acute lung injury improved gas exchange and hemodynamics.

  8. ET(A) blockade had no effect on pulmonary vascular resistance at rest or during exercise.

  9. PKC (show FYN Proteins) and MAPK (show MAPK1 Proteins) seem to be involved in the regulation of endothelin type A and type B receptor expression in porcine coronary arteries

Cow (Bovine) Endothelin Receptor Type A (EDNRA) interaction partners

  1. Data suggest that, in Fallopian tubes, endothelins (EDN1 (show EDN1 Proteins), EDN2 (show EDN2 Proteins), EDN3 (show EDN3 Proteins)) and EDN (show RNASE2 Proteins)-converting enzymes (ECE1 (show ECE1 Proteins), ECE2 (show ECE2 Proteins)) are expressed in epithelial cells; EDN (show RNASE2 Proteins) receptors (EDNRA, EDNRB (show EDNRB Proteins)) are present in smooth-muscle. Expression of EDN1 (show EDN1 Proteins), EDN2 (show EDN2 Proteins), and ECE2 (show ECE2 Proteins) is highest on day of ovulation. EDN (show RNASE2 Proteins)/ENDR signaling appears to participate Fallopian tube function. These studies were conducted in Holstein cows.

  2. Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy.

  3. Elevated local expression of ET-1 (show EDN1 Proteins) and Ednra/Ednrb (show EDNRB Proteins) during the peri (show PLIN1 Proteins)-ovulatory period induces the high contractile activity of the oviduct to optimize gamete transport.

Endothelin-1 Receptor (EDNRA) Protein Profile

Protein Summary

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Endothelin-1 Receptor (EDNRA)

  • endothelin receptor type A (EDNRA)
  • endothelin receptor type Aa (ednraa)
  • endothelin receptor type A (ednra-a)
  • endothelin receptor type A (ednra)
  • endothelin receptor type A (etr)
  • endothelin receptor type A (Ednra)
  • secreted phosphoprotein 1 (Spp1)
  • 2AR protein
  • Apl-1 protein
  • BNSP protein
  • Bsp protein
  • BSPI protein
  • ednr-a protein
  • ednra protein
  • ednraa protein
  • Endor protein
  • ET-A protein
  • ET-AR protein
  • ETa protein
  • ETA-1 protein
  • ETA-R protein
  • ETAR protein
  • ETRA protein
  • Gpcr10 protein
  • hET-AR protein
  • OP protein
  • Opn protein
  • Opnl protein
  • RGD1559432 protein
  • Ric protein
  • Spp-1 protein
  • wu:fb75g12 protein

Protein level used designations for EDNRA

endothelin-1 receptor , Ednra2 , endothelin receptor A , endothelin receptor type A , endothelin type-A receptor 2 , etID40953.1 , Endothelin-1 receptor type A , endothelin receptor type A a , G protein-coupled receptor , endothelin receptor subtype A , endothelin-1-specific receptor , endothelin A receptor , ET-A , G-protein coupled receptor 10 , ET-AR , 44 kDa bone phosphoprotein , bone sialoprotein 1 , calcium oxalate crystal growth inhibitor protein , early T-lymphocyte activation 1 protein , minopontin , osteopontin , osteopontin-like protein

100062644 Equus caballus
114550 Danio rerio
380342 Xenopus laevis
779728 Xenopus (Silurana) tropicalis
100049646 Takifugu rubripes
1909 Homo sapiens
24326 Rattus norvegicus
13617 Mus musculus
373908 Gallus gallus
450187 Canis lupus familiaris
397457 Sus scrofa
281749 Bos taurus
443465 Ovis aries
20750 Mus musculus
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