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Study provides evidence that GAL (show GAL ELISA Kits) and GALR1/2 genes were identified as aberrantly methylated in head and neck squamous cell carcinoma.
The MOR (show OPRM1 ELISA Kits)-Gal1R heteromer can explain previous results showing antagonistic galanin (show GAL ELISA Kits)-opioid interactions and offers a new therapeutic target for the treatment of opioid use disorder
GAL (show GAL ELISA Kits) and its receptors, GALR1 and GALR2 (show GALR2 ELISA Kits), play a role in head and neck squamous cell carcinoma tumorigenesis
Variants in genes for galanin (GAL (show GAL ELISA Kits)) and its receptors (GALR1, GALR2 (show GALR2 ELISA Kits), GALR3 (show GALR3 ELISA Kits)), despite their disparate genomic loci, conferred increased risk of depression and anxiety in people who experienced childhood adversity or recent negative life events.
GALR1 methylation is associated with endometrial cancer.
Moreover, we have identified a novel role for the GalR1/galanin (show GAL ELISA Kits) receptor-ligand axis in chemoresistance, providing evidence to support its further evaluation as a potential therapeutic target and biomarker in colorectal cancer .
Genetic variants in the GALR1 gene are associated with a protective effect in nicotine dependence.
The results of this study suggested an association between variation at the GALR1 locus and baseline craving for tobacco in smokers seeking cessation treatment.
it has been demonstrated that GalR1-5-HT1A (show HTR1A ELISA Kits) receptors heteromerize.
disregulation of galanin receptor 1 may lead to uncontrolled proliferation and neoplastic transformation
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 (show CNR1 ELISA Kits) receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD ELISA Kits) muscarinic receptor (show CHRM5 ELISA Kits) subtypes was also analyzed in brain areas involved in anxiety and cognition.
Galanin (show GAL ELISA Kits), acting via the GAL1 (show LGALS1 ELISA Kits) receptor and Gi -coupled signalling in L and K cells, is a potent inhibitor of GLP-1 (show GCG ELISA Kits) and GIP (show GIP ELISA Kits) secretion
endogenous Gal-1 (show LGALS1 ELISA Kits) may influence T. cruzi infection by fueling tolerogenic circuits that hinder anti-parasite immunity.
Experiments with a GalR1-preffering galanin (show GAL ELISA Kits) analog, NAX (show SCN7A ELISA Kits)-5055, show that GalR1 is involved in regulating glucose and insulin (show INS ELISA Kits) homeostasis
two different models of chronic pain requires a galanin receptor 1-triggered depression of excitatory synaptic transmission in indirect pathway nucleus accumbens medium spiny neurons.
GalR1 expression is increased in the nucleus accumbens after chronic restraint stress.
Galanin (show GAL ELISA Kits) opposes the actions of morphine which leads to opiate dependence and withdrawal, an effect that is mediated via GalR1
Galanin receptor 1 deletion exacerbates hippocampal neuronal loss after systemic kainate administration in mice
Rotavirus infection of murine small intestine causes colonic secretion via age restricted galanin (show GAL ELISA Kits)-1 receptor expression.
Homozygous Galr1-/- mice are viable, capable of breeding, and exhibit no significant difference in growth rate. They have reduced circulating levels of insulin-like growth factor-I (IGF-I (show IGF1 ELISA Kits)) and exhibit spontaneous tonic-clonic seizures.
The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
, galanin receptor type 1
, galanin receptor 1
, galactose operon repressor
, LacI family transcriptional regulatory protein