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Results show regulation of melanocortin receptors MC2R, MC3R (show MC3R ELISA Kits) and MC4R (show MC4R ELISA Kits) gene expressions in CD8 (show CD8A ELISA Kits)(+) cytotoxic T-lymphocytes and CD19 (show CD19 ELISA Kits)(+) B lymphocytes in rheumatoid arthritis (RA) treated with tumor necrosis factor-alpha (TNF-alpha (show TNF ELISA Kits)) inhibitor (show ZFP36 ELISA Kits) adalimumab.
Four rare missense variants were identified (ACTBL2 (show ACTBL2 ELISA Kits) rs73757391 (5q11.2), BTD (show BTD ELISA Kits) rs200337373 (3p25.1), KRT13 (show KRT13 ELISA Kits) rs150321809 (17q21.2) and MC2R rs104894658 (18p11.21)), but only MC2R rs104894668 had a large effect size (OR = 9.66).
melanocortin receptors MC2R, MC3R (show MC3R ELISA Kits) and MC5R (show MC5R ELISA Kits) are most abundantly expressed in glandular epithelium of the endometrium
MC2R and MC1R (show MSHR ELISA Kits) signals are consecutively required for the regulation of EPO (show EPO ELISA Kits) signal transduction in erythroblast differentiation, and MC5R (show MC5R ELISA Kits) signal transduction is required to induce enucleation.
the MC2R gene may contribute to the development of intracerebral hemorrhage.
The A allele at rs1941088 in the MC2R gene, which encodes the adrenocorticotropic hormone (corticotropin, ACTH) receptor, is associated with a low cortisol response in critically ill children.
results suggest that Phe(7) in ACTH (show POMC ELISA Kits) plays an important role in ligand selectivity and that the third transmembrane domain of MC2R is crucial for ACTH (show POMC ELISA Kits) selectivity and potency
MC2R overexpression is associated with myelolipomas.
The patient with familial glucocorticoid deficiency was found to be homozygous for a novel mutation in the melanocortin-2 receptor gene (635insC, I154H).
Our observations suggest that MC2R is involved in prostate carcinogenesis and that targeting MC2R signaling may provide a novel avenue in prostate carcinoma treatment.
JDP2 (show JDP2 ELISA Kits) acts as a novel transcriptional activator of the mouse Mc2r gene, suggesting that JDP2 (show JDP2 ELISA Kits) may have physiological functions as a novel player in MC2R-mediated steroidogenesis as well as cell signaling in adrenal glands.
Data show that neuromedin B (NMB) expression was higher in the melanocortin 2 receptor MC2R(-/-) than in the wild-type (WT) mice.
MC2R plays an important role for regular lipolytic function and lipid composition in 3T3-L1 adipocytes.
melanocortin 2 receptor and melanocortin 5 receptor (show MC5R ELISA Kits) are lipolytic mediators in differentiated 3T3-L1 adipocytes
MC2R+/- pups delivered from MC2R-/- females crossed with MC2R+/+ males mice thrived poorly with MC2R-/- mothers but grew to adulthood when transferred to foster mothers after birth, suggesting that MC2R-/- females are poor mothers or cannot nurse.
The promoter activity of Mc2r is activated by FOXL2 (show FOXL2 ELISA Kits) in a dose-dependent manner; transcriptional activity of Mc2r is up-regulated by synergistic interaction of FOXL2 (show FOXL2 ELISA Kits) and NR5A1 (show NR5A1 ELISA Kits).
Data show that melanocortins regulate Il6 (show IL6 ELISA Kits) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
MC2R in Y1 cells internalizes by a G protein coupled receptor (show GPR34 ELISA Kits) kinase dependent clathrin-coated pit (show IRF6 ELISA Kits) mechanism.
Data show that adrenocorticotrophic hormone resistance in tumor cell mutants is associated with a base change polymorphism in the steroidogenic factor 1 (show NR5A1 ELISA Kits) gene.
Novel 135-bp exon 1f of ACTH-R gene was located 1.4 kb downstream in genome of exon 1a transcribed in adrenal gland. Promoter region flanking to exon 1f may be essential for adipose tissue; that flanking to exon 1a is specific for the adrenal gland.
zfMC2R is not functional in the absence of MRAP expression.
Data suggest enzymes in steroidogenic pathway are induced in interrenal cells during acute/chronic stress: MC2R (melanocortin 2 receptor); StAR (steroidogenic acute regulatory protein (show STAR ELISA Kits)); 3beta-hydroxysteroid dehydrogenase; steroid 11beta hydroxylase.
Rainbow trout melanocortin-2 receptor structure and function analysis.
ACTH (show POMC ELISA Kits) regulation of MC2R is highly conserved in vertebrates.
MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency.
, MC2 receptor
, adrenocorticotropic hormone receptor
, adrenocorticotropin receptor
, corticotropin receptor
, melanocortin receptor 2
, melanocortin 2 receptor
, melanocortin 2-receptor
, adrenal ACTH receptor
, G-protein-coupled receptor
, melanocortin 2 receptor-like
, putative melanocortin 2 receptor
, Adrenocorticotropin receptor
, Melanocortin receptor 2
, melanocortin 2 receptor (adrenocorticotropic hormone receptor)