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anti-Mouse (Murine) MC3R Antibodies:
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Human Polyclonal MC3R Primary Antibody for IHC (fro), IP - ABIN493099
Wikberg, Muceniece, Mandrika, Prusis, Lindblom, Post, Skottner: New aspects on the melanocortins and their receptors. in Pharmacological research : the official journal of the Italian Pharmacological Society 2000
Show all 4 references for ABIN493099
Human Polyclonal MC3R Primary Antibody for IHC (fro), IP - ABIN2712096
Butler, Cone: Knockout studies defining different roles for melanocortin receptors in energy homeostasis. in Annals of the New York Academy of Sciences 2003
Show all 4 references for ABIN2712096
Human Polyclonal MC3R Primary Antibody for IHC (fro), IP - ABIN493097
Getting, Christian, Lam, Gavins, Flower, Schiöth, Perretti: Redundancy of a functional melanocortin 1 receptor in the anti-inflammatory actions of melanocortin peptides: studies in the recessive yellow (e/e) mouse suggest an important role for melanocortin 3 receptor. in Journal of immunology (Baltimore, Md. : 1950) 2003
Show all 4 references for ABIN493097
Human Polyclonal MC3R Primary Antibody for EIA, WB - ABIN453742
Magenis, Smith, Nadeau, Johnson, Mountjoy, Cone: Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. in Mammalian genome : official journal of the International Mammalian Genome Society 1994
Show all 2 references for ABIN453742
Chimpanzee Polyclonal MC3R Primary Antibody for WB - ABIN374548
Mühlhäusler, Adam, Marrocco, Findlay, Roberts, McFarlane, Kauter, McMillen et al.: Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late ... in The Journal of physiology 2005
Replacing murine Mc3r with and double-mutant (C17A+G241A) human MC3R showed greater weight and fat mass, increased energy intake and feeding efficiency.
MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
The minimum promoter region required for Mc3r expression has been identified, along with two binding sites for AP-1 (show JUN Antibodies) and ATF4 (show ATF4 Antibodies) and in the 5' upstream-flanking region of Mc3r that are essential for Mc3r expression.
3' RACE experiments using hypothalamic RNA indicated the 3' UT (show UTS2R Antibodies)R terminates approximately 1286 bases after the translational stop codon, with a previously unknown 787 base splice between consensus splice donor and acceptor sites.
These data reveal novel protective properties of endogenous MC3 on periodontal status in health and disease
Data suggest that Mc3r (not Mc4r (show MC4R Antibodies)) is expressed in 1/3 of dopaminergic neurons in ventral tegmental area (VTA); global deletion of Mc3r in knockout mice increases VTA dopamine by 42% and decreases sucrose intake/preference in female (not male) mice.
Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin (show GHRL Antibodies) and melanocortin-3 receptors.
data suggest that the melanocortin-3 receptor is involved in the control of energy balance and the expression of rhythms anticipating nutrient intake.
MC(3) plays a subtle role in the regulation of food intake
Compared with WT, MC4R (show MC4R Antibodies)-/- showed no activation in area postrema but showed normal activation in paraventricular hypothalamus, whereas MC3R-/- showed reduced activation in PVN but not in AP.
findings support the role of MC3R genetic variants in adiposity gain during early childhood.
There is no evidence of any association between MC3R variations and obesity.
melanocortin receptors MC2R (show MC2R Antibodies), MC3R and MC5R (show MC5R Antibodies) are most abundantly expressed in glandular epithelium of the endometrium
the DPLIY motif and helix 8 was important for MC3R activation and signal transduction. The data led to a better understanding of the structure-function relationship of MC3R.
novel data about the structure-function relationship of MC3R, identifying residues important for receptor function; some studied mutations exhibited biased signaling, preferentially activating one intracellular signaling pathway.
propose three potential human candidate genes for voluntary physical exercise levels (MC3R, CYP24A1 (show CYP24A1 Antibodies), and GRM8 (show GRM8 Antibodies)).
The cytoplasmic end of transmembrane domain 3 and the intracellular loop 2 were critical for MC3R function.
MC3R polymorphism is marginally associated in the development of pulmonary tuberculosis in Korean population.
MC3R is a 2-exon gene that requires a 5' UTR for translation, localization, and potential interaction with MRAP2
This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans.
melanocortin receptor 3
, melanocortin-3 receptor
, obesity quantitative trait locus