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melanocortin receptors MC2R, MC3R (show MC3R Proteins) and MC5R are most abundantly expressed in glandular epithelium of the endometrium
MC2R and MC1R (show MSHR Proteins) signals are consecutively required for the regulation of EPO (show EPO Proteins) signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation.
D115 and D119 in TM3 (show TPM1 Proteins), F195 in TM5, and F254 in TM6 may form a binding pocket for NDP (show NDP Proteins)-alpha-MSH binding.
Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK (show MAPK1 Proteins) pathway and beta-arrestins 1/2.
Data suggest that antagonists of MC1R (show MSHR Proteins) and MC5R could be effective inhibitors of sebaceous gland differentiation and the production of sebum-specific lipids.
Variations in the melanocortin 5 receptor gene are unlikely to confer susceptibility to bipolar disorder in this sample.
Further structure-activity studies of lactam derivatives of MT-II (show MT2 Proteins) and SHU-9119 were made at MC5R.
MC5R signals through a PI3K-regulated Akt-independent pathway leading to downstream activation of ERK1/2
MC5r-dependent regulatory immunity increased CD11b (show ITGAM Proteins)(+)F4/80(+)Ly-6C(low)Ly-6G(+)CD39 (show ENTPD1 Proteins)(+)CD73(+) APCs (show APCS Proteins) in the spleen of post-experimental autoimmune uveoretinitis mice.
In 3T3-L1 adipocytes, alpha-MSH-activated MC5-R signals through the cAMP/PKA and MAPK/ERK1/2 pathways.
Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Dependence on MC5r expression promotes or selectively activates IRBP (show RBP3 Proteins)-specific FoxP3 (show FOXP3 Proteins)+ TGF-beta (show TGFB1 Proteins)+ CD25 (show IL2RA Proteins)+CD4 (show CD4 Proteins)+ Treg cells in the spleens of experimental uveitis-recovered mice.
melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes
Data show that melanocortins regulate Il6 (show IL6 Proteins) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor.
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.
, melanocortin receptor 5
, G-protein-coupled receptor
, melanocortin 5 receptor
, melanocortin 1 receptor Mc1r
, melanocortin-5 receptor