Browse our MC5 Receptor Proteins (MC5R)

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Melanocortin 5 Receptor Proteins (MC5R)
On are 3 Melanocortin 5 Receptor (MC5R) Proteins from 2 different suppliers available. Additionally we are shipping MC5 Receptor Antibodies (105) and MC5 Receptor Kits (17) and many more products for this protein. A total of 131 MC5 Receptor products are currently listed.
MC2, MC5, MC5R
list all proteins Gene Name GeneID UniProt
MC5R 4161 P33032
MC5R 17203  
Rat MC5R MC5R 25726 P35345

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MC5 Receptor Proteins (MC5R) by Origin

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Human Melanocortin 5 Receptor (MC5R) interaction partners

  1. melanocortin receptors MC2R, MC3R (show MC3R Proteins) and MC5R are most abundantly expressed in glandular epithelium of the endometrium

  2. MC2R and MC1R (show MSHR Proteins) signals are consecutively required for the regulation of EPO (show EPO Proteins) signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation.

  3. D115 and D119 in TM3 (show TPM1 Proteins), F195 in TM5, and F254 in TM6 may form a binding pocket for NDP (show NDP Proteins)-alpha-MSH binding.

  4. Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK (show MAPK1 Proteins) pathway and beta-arrestins 1/2.

  5. Data suggest that antagonists of MC1R (show MSHR Proteins) and MC5R could be effective inhibitors of sebaceous gland differentiation and the production of sebum-specific lipids.

  6. Variations in the melanocortin 5 receptor gene are unlikely to confer susceptibility to bipolar disorder in this sample.

  7. Further structure-activity studies of lactam derivatives of MT-II (show MT2 Proteins) and SHU-9119 were made at MC5R.

  8. MC5R signals through a PI3K-regulated Akt-independent pathway leading to downstream activation of ERK1/2

Mouse (Murine) Melanocortin 5 Receptor (MC5R) interaction partners

  1. MC5r-dependent regulatory immunity increased CD11b (show ITGAM Proteins)(+)F4/80(+)Ly-6C(low)Ly-6G(+)CD39 (show ENTPD1 Proteins)(+)CD73(+) APCs (show APCS Proteins) in the spleen of post-experimental autoimmune uveoretinitis mice.

  2. In 3T3-L1 adipocytes, alpha-MSH-activated MC5-R signals through the cAMP/PKA and MAPK/ERK1/2 pathways.

  3. Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.

  4. Dependence on MC5r expression promotes or selectively activates IRBP (show RBP3 Proteins)-specific FoxP3 (show FOXP3 Proteins)+ TGF-beta (show TGFB1 Proteins)+ CD25 (show IL2RA Proteins)+CD4 (show CD4 Proteins)+ Treg cells in the spleens of experimental uveitis-recovered mice.

  5. melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes

  6. Data show that melanocortins regulate Il6 (show IL6 Proteins) gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.

  7. The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor.

MC5 Receptor (MC5R) Protein Profile

Protein Summary

This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.

Alternative names and synonyms associated with MC5 Receptor (MC5R)

  • melanocortin 5 receptor (MC5R)
  • melanocortin 5 receptor (mc5r)
  • melanocortin 5 receptor (LOC100226898)
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R)
  • melanocortin 5 receptor (Mc5r)
  • melanocortin receptor 5-like (LOC100622278)
  • MC2 protein
  • MC5 protein
  • MC5R protein

Protein level used designations for Melanocortin 5 Receptor Proteins (MC5R)

melanocortin 5-receptor , melanocortin receptor 5 , G-protein-coupled receptor , melanocortin 5 receptor , MC5-R , melanocortin 1 receptor Mc1r , melanocortin-5 receptor

421047 Gallus gallus
445999 Takifugu rubripes
483981 Canis lupus familiaris
100124993 Xenopus (Silurana) tropicalis
100226898 Taeniopygia guttata
780501 Ovis aries
4161 Homo sapiens
17203 Mus musculus
25726 Rattus norvegicus
507987 Bos taurus
468599 Pan troglodytes
100622278 Sus scrofa
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