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PDE7B polymorphisms were not associated with schizophrenia risk.
higher expression of PDE7B might be a novel unfavorable prognostic indicator in MCL (show FH Proteins), which possess important clinical significance.
PDE7B mRNA expression is obviously higher in mantle cell lymphoma patients compared with normal controls and significantly correlates with unfavorable cytogenetic characteristics.
The low frequency of this 5' untranslated region variant indicates that it does not explain the higher PDE7B expression in patients with chronic lymphocytic leukemia (CLL) but it has the potential to influence other settings that involve a role for PDE7B.
High PDE7B is associated with chronic lymphocytic leukemia.
Genetic variation in the phosphodiesterase 7B is associated with bioavailability of testosterone enanthate.
As a first exploitation of this unique cohort, we identify three novel candidate dyslexia genes, ZNF280D and TCF12 (show TCF12 Proteins) at 15q21, and PDE7B at 6q23.3, by molecular mapping of the familial translocation with the 15q21 breakpoint.
higher levels than in normal B-cell of PDE7B are found in chronic lymphocytic leukemia
For the first time, it was demonstrated that the deletion of the PDE7B gene or the pharmacological inhibition of PDE7A (show PDE7A Proteins) and -B had no effect on ovalbumin (show OVA Proteins)-induced airway inflammation and airway hyperreactivity.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family.
, cAMP-specific 3',5'-cyclic phosphodiesterase 7B-like
, cyclic nucleotide phosphodiesterase 7b
, cAMP-specific 3',5'-cyclic phosphodiesterase 7B
, high-affinity cAMP-specific 3',5'-cyclic phosphodiesterase
, rolipram-insensitive phosphodiesterase type 7