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SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq
PDE8A supports HIV-1 replication in macrophages
PDE8A can bind tightly to Raf-1 (show RAF1 Proteins), regulate Raf-1 (show RAF1 Proteins) phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 (show RAF1 Proteins) signaling, retarding subsequent ERK (show EPHB2 Proteins) phosphorylation and activation.
PDE8 activity can be modulated by a kinase
Polymorphism in PDE8A affects HIV-1 replication in primary macrophages.
Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A.
The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las (show LIAS Proteins) major determinant of androgen levels in women.
findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH (show EPHX2 Proteins)/HSL (show LIPE Proteins) inactive and StAR protein expression low
PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells
PDE8A plays a critical role in the modulation of at least one compartment of cAMP and hence PKA activity during beta-adrenergic receptor (betaAR) activation in ventricular myocytes.
pharmacological manipulation of PDE8A, alone or in combination with other PDEs present in Leydig cells, may be exploited to modulate testosterone synthesis
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
, phosphodiesterase 8a
, high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like
, cAMP-specific cyclic nucleotide phosphodiesterase 8A
, cAMP-specific cyclic nucleotide phosphodiesterase PDE8