Browse our PDE8A Proteins (PDE8A)

Full name:
phosphodiesterase 8A Proteins (PDE8A)
On are 5 phosphodiesterase 8A (PDE8A) Proteins from 3 different suppliers available. Additionally we are shipping PDE8A Antibodies (78) and many more products for this protein. A total of 91 PDE8A products are currently listed.
AI551852, HsT19550, Pde8, Pde8a, RNPDE8A
list all proteins Gene Name GeneID UniProt
PDE8A 5151 O60658
PDE8A 18584 O88502
PDE8A 308776  

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PDE8A Proteins (PDE8A) by Origin

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More Proteins for PDE8A Interaction Partners

Human phosphodiesterase 8A (PDE8A) interaction partners

  1. SNPs within genes SCHIP1 and PDE8A were associated with measures of facial size in both the GWAS and replication cohorts and passed a stringent genomewide significance threshold adjusted for multiple testing of 34 correlated traits. For both SCHIP1 and PDE8A, we demonstrated clear expression in the developing mouse face by both whole-mount in situ hybridization and RNA-seq

  2. PDE8A supports HIV-1 replication in macrophages

  3. PDE8A can bind tightly to Raf-1 (show RAF1 Proteins), regulate Raf-1 (show RAF1 Proteins) phosphorylation on S259, and, in so doing, regulate the cross-talk node whereby cAMP exerts an inhibitory effect on Raf-1 (show RAF1 Proteins) signaling, retarding subsequent ERK (show EPHB2 Proteins) phosphorylation and activation.

  4. PDE8 activity can be modulated by a kinase

  5. Polymorphism in PDE8A affects HIV-1 replication in primary macrophages.

  6. Comparison of enzymatic characterization and gene organization of PDE8B and PDE8A.

  7. The findings exclude a significant role for PDE8A as a PCOS candidate gene, and as a Las (show LIAS Proteins) major determinant of androgen levels in women.

Mouse (Murine) phosphodiesterase 8A (PDE8A) interaction partners

  1. findings suggest that both PDE8A and PDE8B play essential roles to maintain low cAMP levels, thereby suppressing resting steroidogenesis by keeping CEH (show EPHX2 Proteins)/HSL (show LIPE Proteins) inactive and StAR protein expression low

  2. PDE8 as a novel target for suppression of Teff cell functions, including adhesion to endothelial cells

  3. PDE8A plays a critical role in the modulation of at least one compartment of cAMP and hence PKA activity during beta-adrenergic receptor (betaAR) activation in ventricular myocytes.

  4. pharmacological manipulation of PDE8A, alone or in combination with other PDEs present in Leydig cells, may be exploited to modulate testosterone synthesis

PDE8A Protein Profile

Protein Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with PDE8A

  • phosphodiesterase 8A (PDE8A)
  • phosphodiesterase 8a (Pde8a)
  • phosphodiesterase 8A (pde8a)
  • phosphodiesterase 8A (LOC100223556)
  • phosphodiesterase 8A (LOC100343099)
  • phosphodiesterase 8A (Pde8a)
  • AI551852 protein
  • HsT19550 protein
  • Pde8 protein
  • Pde8a protein
  • RNPDE8A protein

Protein level used designations for phosphodiesterase 8A Proteins (PDE8A)

phosphodiesterase 8A , high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A , phosphodiesterase 8a , high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like , cAMP-specific cyclic nucleotide phosphodiesterase 8A , mmPDE8 , cAMP-specific cyclic nucleotide phosphodiesterase PDE8

415455 Gallus gallus
453612 Pan troglodytes
488752 Canis lupus familiaris
506787 Bos taurus
694750 Macaca mulatta
100010222 Monodelphis domestica
100302670 Cavia porcellus
100456736 Pongo abelii
100497070 Xenopus (Silurana) tropicalis
100514527 Sus scrofa
100579512 Nomascus leucogenys
100223556 Taeniopygia guttata
100343099 Oryctolagus cuniculus
5151 Homo sapiens
18584 Mus musculus
308776 Rattus norvegicus
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