Browse our anti-PKD2 (PKD2) Antibodies

Full name:
anti-Polycystic Kidney Disease 2 (Autosomal Dominant) Antibodies (PKD2)
On www.antibodies-online.com are 93 Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) Antibodies from 19 different suppliers available. Additionally we are shipping PKD2 Proteins (15) and PKD2 Kits (10) and many more products for this protein. A total of 123 PKD2 products are currently listed.
Synonyms:
AI325941, APKD2, C030034P18Rik, Pc-2, PC2, PKD2, PKD4, RGD1559992, TRPP2
list all antibodies Gene Name GeneID UniProt
PKD2 18764 O35245
PKD2 5311 Q13563
PKD2 498328  

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anti-Mouse (Murine) PKD2 Antibodies:

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Top referenced anti-PKD2 Antibodies

  1. Human Polyclonal PKD2 Primary Antibody for EIA, WB - ABIN954155 : Duning, Rosenbusch, Schlüter, Tian, Kunzelmann, Meyer, Schulze, Markoff, Pavenstädt, Weide: Polycystin-2 activity is controlled by transcriptional coactivator with PDZ binding motif and PALS1-associated tight junction protein. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for 954155

  2. Human Polyclonal PKD2 Primary Antibody for ELISA, WB - ABIN4346790 : Fencl, Janda, Bláhová, Hríbal, Stekrová, Puchmajerová, Seeman: Genotype-phenotype correlation in children with autosomal dominant polycystic kidney disease. in Pediatric nephrology (Berlin, Germany) 2009 (PubMed)

More Antibodies against PKD2 Interaction Partners

Mouse (Murine) Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) interaction partners

  1. Our studies demonstrate that PKD1 (show PKD1 Antibodies)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Antibodies) effect on MVB secretory traffic.

  2. Pkd2(-/-) mice with homozygous PKD2(tg)-transgene alleles (Pkd2(-/-);PKD2(tg/tg)) showed significant further amelioration of the cystic severity compared to that in Pkd2(-/-) mice

  3. Results reveal that whereas protein kinase D1 (show PRKD1 Antibodies) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.

  4. Pkd1 (show PKD1 Antibodies) and Pkd2 have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 (show PKD1 Antibodies) and Pkd2 signaling pathways can have independent effects on mesenchymal lineage commitment in bone

  5. novel protein complex composed of Rabep1 (show RABEP1 Antibodies), GGA1 (show GGA1 Antibodies) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Antibodies) andpolycystin 2 to the cilium.

  6. PKD2 regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome.

  7. The results of this study demonstrate that PC1 (show PCSK1 Antibodies) trafficking and expression require GPS (show NBEAL2 Antibodies) cleavage and PC2 (show CBX4 Antibodies) interaction, respectively, and provide a framework for functional assays to categorize the effects of missense mutations in polycystins.

  8. PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (show CD8A Antibodies)(+) T cells that became effector cells.

  9. In inner medullary collecting duct, flow, via polycystin-2 and P2 receptors, engages Ca(2 (show CA2 Antibodies)+)-dependent signaling pathways that stimulate ET-1 (show EDN1 Antibodies) synthesis.

  10. Pkd2(+/-) cardiomyocytes shift the beta adrenergic receptor pathway and have altered calcium handling, independent of desensitized calcium-contraction coupling.

Human Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) interaction partners

  1. Here, we review previous studies that connect the molecular properties of the domains of PC2 (show KRT6B Antibodies) Cterm to distinct aspects of PC2 (show KRT6B Antibodies) functions and regulation.

  2. Data show that in 82 (87.2%) of the patients, pathogenic mutations were detected in PKD1 (show PKD1 Antibodies) (79.0%-92.5%), whereas in 12 (12.8%) patients pathogenic mutations were detected in PKD2 (7.5%-21.0%).

  3. Two cryo-EM structures of distinct channel states of full-length human PC2 (show KRT6B Antibodies) in complex with lipids and cations.

  4. The structure of human PC2 (show KRT6B Antibodies) in a closed conformation, solved by electron cryomicroscopy at 4.2-A resolution.

  5. SNPs in and near PKD2 showed significant evidence of association in individual samples of black adults (rs17013735, P-value=0.0009) and white adults (rs11938025; P-value=0.0005; rs2725270, P-value=0.003).

  6. Pancreatic cysts were more prevalent in patients with ADPKD with PKD2 mutation than in control subjects or patients with PKD1 (show PKD1 Antibodies) mutation.

  7. This suggests that a precise dosage of PC2 (show KRT6B Antibodies) is necessary for an adequate mechanosensitive alpha-actinin (show ACTN1 Antibodies) recruitment at junctions.

  8. PKD1 (show PKD1 Antibodies) and PKD2 are susceptibility genes for familial intracranial aneurysms in a Japanese population.

  9. Novel PKD2 mutations in Chinese autosomal dominant polycystic kidney disease patients

  10. Two neutral missense PKD2 variants indentified in exon1 c.83G>C (p.R28P) and c.568G>A (p.A190T), which the former segregate with the mutation in affected relatives, and two new intronic and 3'UTR (show UTS2R Antibodies) variants, c.1548+63C>T and c.*363delA.

Caenorhabditis elegans (C. elegans) Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) interaction partners

  1. These data reveal that the STAM (show STAM Antibodies)-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 (show PCSK1 Antibodies) receptor-TRPP2 complex.

  2. Results demonstrate that somatodendritic and ciliary targeting of PKD-2 requires the transmembrane region of PKD-2 and that the PKD-2 cytosolic termini regulate subcellular distribution and function.

  3. 11 mutants found with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel

PKD2 Antigen Profile

Antigen Summary

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.

Alternative names and synonyms associated with PKD2

  • polycystic kidney disease 2 (Pkd2) antibody
  • polycystic kidney disease 2 (autosomal dominant) (PKD2) antibody
  • polycystic kidney disease 2 (autosomal dominant) (Pkd2) antibody
  • protein kinase D2 (Prkd2) antibody
  • Protein PKD-2 (pkd-2) antibody
  • AI325941 antibody
  • APKD2 antibody
  • C030034P18Rik antibody
  • Pc-2 antibody
  • PC2 antibody
  • PKD2 antibody
  • PKD4 antibody
  • RGD1559992 antibody
  • TRPP2 antibody

Protein level used designations for PKD2

polycystic kidney disease 2 protein homolog , polycystin 2 , polycystin-2 , R48321 , autosomal dominant polycystic kidney disease type II protein , polycystwin , transient receptor potential cation channel, subfamily P, member 2 , polycystic kidney disease 2 homolog , polycystic kidney disease 2 membrane protein , nPKC-D2 , serine/threonine-protein kinase D2

GENE ID SPECIES
18764 Mus musculus
5311 Homo sapiens
498328 Rattus norvegicus
530393 Bos taurus
422585 Gallus gallus
487852 Canis lupus familiaris
101540 Mus musculus
178424 Caenorhabditis elegans
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