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Browse our PKD2 Proteins (PKD2)

Full name:
Polycystic Kidney Disease 2 (Autosomal Dominant) Proteins (PKD2)
On are 14 Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) Proteins from 4 different suppliers available. Additionally we are shipping PKD2 Antibodies (94) and PKD2 Kits (9) and many more products for this protein. A total of 121 PKD2 products are currently listed.
AI325941, APKD2, C030034P18Rik, Pc-2, PC2, PKD2, PKD4, RGD1559992, TRPP2
list all proteins Gene Name GeneID UniProt
PKD2 18764 O35245
PKD2 5311 Q13563
Rat PKD2 PKD2 498328  

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PKD2 Proteins (PKD2) by Origin

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More Proteins for PKD2 Interaction Partners

Mouse (Murine) Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) interaction partners

  1. Our studies demonstrate that PKD1 (show PKD1 Proteins)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Proteins) effect on MVB secretory traffic.

  2. Pkd2(-/-) mice with homozygous PKD2(tg)-transgene alleles (Pkd2(-/-);PKD2(tg/tg)) showed significant further amelioration of the cystic severity compared to that in Pkd2(-/-) mice

  3. Results reveal that whereas protein kinase D1 (show PRKD1 Proteins) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.

  4. Pkd1 (show PKD1 Proteins) and Pkd2 have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 (show PKD1 Proteins) and Pkd2 signaling pathways can have independent effects on mesenchymal lineage commitment in bone

  5. novel protein complex composed of Rabep1, GGA1 (show GGA1 Proteins) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 Proteins) andpolycystin 2 to the cilium.

  6. PKD2 regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome.

  7. The results of this study demonstrate that PC1 (show PCSK1 Proteins) trafficking and expression require GPS cleavage and PC2 (show CBX4 Proteins) interaction, respectively, and provide a framework for functional assays to categorize the effects of missense mutations in polycystins.

  8. PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (show CD8A Proteins)(+) T cells that became effector cells.

  9. In inner medullary collecting duct, flow, via polycystin-2 and P2 receptors, engages Ca(2 (show CA2 Proteins)+)-dependent signaling pathways that stimulate ET-1 (show EDN1 Proteins) synthesis.

  10. Pkd2(+/-) cardiomyocytes shift the beta adrenergic receptor pathway and have altered calcium handling, independent of desensitized calcium-contraction coupling.

Human Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) interaction partners

  1. PKD1 (show PKD1 Proteins) and PKD2 are susceptibility genes for familial intracranial aneurysms in a Japanese population.

  2. Novel PKD2 mutations in Chinese autosomal dominant polycystic kidney disease patients

  3. Two neutral missense PKD2 variants indentified in exon1 c.83G>C (p.R28P) and c.568G>A (p.A190T), which the former segregate with the mutation in affected relatives, and two new intronic and 3'UTR variants, c.1548+63C>T and c.*363delA.

  4. this study presents the cryo-EM structure of PKD2 in lipid bilayers at 3.0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into potential mechanisms for its activation.

  5. PCs expression and p53 (show TP53 Proteins) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.

  6. PKD2 and RSK1 (show RPS6KA1 Proteins) regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.

  7. The coiled-coil domain in the PC2 (show KRT6B Proteins) C-terminal forms a stable helix bundle regardless of the presence of Ca(2 (show CA2 Proteins)+).

  8. Results show that some of the previously reported missense or synonymous mutations in PKD2 gene caused altered pre-mRNA splicing.

  9. PKD2 is a core factor in the formation of this multiprotein complex at the TGN (show TG Proteins) that controls constitutive secretion of matrix metalloproteinase (show MMP20 Proteins) cargo.

  10. Human polycystin-2 transgene dose-dependently rescues autosomal-dominant polycystic kidney disease phenotypes in Pkd2 mutant mice

Caenorhabditis elegans (C. elegans) Polycystic Kidney Disease 2 (Autosomal Dominant) (PKD2) interaction partners

  1. These data reveal that the STAM (show STAM Proteins)-Hrs complex, which down-regulates ligand-activated growth factor receptors from the cell surface of yeast and mammalian cells, also regulates the localization and signaling of a ciliary PC1 (show PCSK1 Proteins) receptor-TRPP2 complex.

  2. Results demonstrate that somatodendritic and ciliary targeting of PKD-2 requires the transmembrane region of PKD-2 and that the PKD-2 cytosolic termini regulate subcellular distribution and function.

  3. 11 mutants found with defects in the ciliary localization (cil) of C. elegans PKD-2, a transient receptor potential polycystin (TRPP) channel

PKD2 Protein Profile

Protein Summary

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2.

Alternative names and synonyms associated with PKD2

  • polycystic kidney disease 2 (Pkd2)
  • polycystic kidney disease 2 (autosomal dominant) (PKD2)
  • polycystic kidney disease 2 (autosomal dominant) (Pkd2)
  • protein kinase D2 (Prkd2)
  • Protein PKD-2 (pkd-2)
  • AI325941 protein
  • APKD2 protein
  • C030034P18Rik protein
  • Pc-2 protein
  • PC2 protein
  • PKD2 protein
  • PKD4 protein
  • RGD1559992 protein
  • TRPP2 protein

Protein level used designations for PKD2

polycystic kidney disease 2 protein homolog , polycystin 2 , polycystin-2 , R48321 , autosomal dominant polycystic kidney disease type II protein , polycystwin , transient receptor potential cation channel, subfamily P, member 2 , polycystic kidney disease 2 homolog , polycystic kidney disease 2 membrane protein , nPKC-D2 , serine/threonine-protein kinase D2

18764 Mus musculus
5311 Homo sapiens
498328 Rattus norvegicus
530393 Bos taurus
422585 Gallus gallus
487852 Canis lupus familiaris
101540 Mus musculus
178424 Caenorhabditis elegans
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