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anti-Human HK3 Antibodies:
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Human Polyclonal HK3 Primary Antibody for IHC (p), WB - ABIN392753
Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997
Show all 4 Pubmed References
Human Polyclonal HK3 Primary Antibody for WB - ABIN392754
Palmieri, Fitzgerald, Shreeve, Hua, Bronder, Weil, Davis, Stark, Merino, Kurek, Mehdorn, Davis, Steinberg, Meltzer, Aldape, Steeg: Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis. in Molecular cancer research : MCR 2009
HK3 expression is significantly upregulated in human masticatory mucosa during wound healing
HK1 (show KCNA4 Antibodies) and HK2 (show HK2 Antibodies) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples.
Through glycolysis and arachidonic acid metabolism, HK3 and PTGS2 (show PTGS2 Antibodies) might play important roles in pediatric ALL and its prognosis, and thus, might be potential targets for therapeutic intervention to suppress pediatric ALL.
Altogether, our data provide an explanation for low HK3 and KLF5 (show KLF5 Antibodies) expression in particular AML (show RUNX1 Antibodies) subtype and establish these genes as novel CEBPA (show CEBPA Antibodies) targets during neutrophil differentiation.
HK3 is: (1) directly activated by PU.1, (2) repressed by PML (show PML Antibodies)-RARA (show RARA Antibodies), and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia (show PML Antibodies) cells.
Data demonstrated that in addition to galectin-3 (show LGALS3 Antibodies), HK III and cyclin A (show CCNA2 Antibodies) profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.
Data show that HKIII exerts protective effects against oxidative stress, perhaps by increasing ATP levels, reducing oxidant-induced ROS (show ROS1 Antibodies) production, preserving mitochondrial membrane potential, and increasing mitochondrial biogenesis.
The expression pattern of HK3 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
plastid HXK enzyme activities, location, function in signal transduction, and cross talk to plastid GUN1 protein (a (show GPR153 Antibodies) key signaling factor) were investigated. pHXK may be a node of convergence for sugar-mediated and PGE (show LIPF Antibodies)-derived signals.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
, HK III
, hexokinase type III
, P-30 antigen
, prostate specific antigen
, prostate-specific antigen
, hexokinase 3 (white cell)