HK3 antibody (N-Term)

Catalog No. ABIN392754

Cited in 1 publication. The Rabbit Polyclonal anti-HK3 antibody (Clone RB5335) (ABIN392754) specifically detects HK3 in WB. The antibody is reactive with Human samples.

Quick Overview for HK3 antibody (N-Term) (ABIN392754)

Target: HK3 (Hexokinase 3 (White Cell) (HK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HK3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5335

Product Details anti-HK3 Antibody

Binding Specificity: AA 1-30, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HK3 (Hexokinase III) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HK3 (Hexokinase III).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-HK3 antibody (ABIN392754)

Palmieri, Fitzgerald, Shreeve, Hua, Bronder, Weil, Davis, Stark, Merino, Kurek, Mehdorn, Davis, Steinberg, Meltzer, Aldape, Steeg: "Analyses of resected human brain metastases of breast cancer reveal the association between up-regulation of hexokinase 2 and poor prognosis." in: Molecular cancer research : MCR, Vol. 7, Issue 9, pp. 1438-45, (2009) (PubMed).

Target Details for HK3

Target: HK3 (Hexokinase 3 (White Cell) (HK3))

Alternative Name: HK3 (Hexokinase III)

Background: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.

Molecular Weight: 99025

Gene ID: 3101

NCBI Accession: NP_002106

UniProt: P52790

Pathways: Carbohydrate Homeostasis, Warburg Effect