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Human HK3 Primary Antibody for SDS - ABIN668034
Furuta, Nishi, Le Beau, Fernald, Yano, Bell: Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. in Genomics 1997
Show all 2 references for ABIN668034
Human HK3 Primary Antibody for - ABIN2003725
Palma, Agostini, Mason, Dachà, Piccoli, Biagiarelli, Fiorani, Stocchi: Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. in Molecular and cellular biochemistry 1997
plastid HXK enzyme activities, location, function in signal transduction, and cross talk to plastid GUN1 protein (a (show GPR153 Proteins) key signaling factor) were investigated. pHXK may be a node of convergence for sugar-mediated and PGE (show LIPF Proteins)-derived signals.
Hexokinase expression is highly enriched in neurons compared to astrocytes.
HK3 expression is significantly upregulated in human masticatory mucosa during wound healing
HK1 (show KCNA4 Proteins) and HK2 (show HK2 Proteins) expression alterations were detected, that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples.
Through glycolysis and arachidonic acid metabolism, HK3 and PTGS2 (show PTGS2 Proteins) might play important roles in pediatric ALL and its prognosis, and thus, might be potential targets for therapeutic intervention to suppress pediatric ALL.
Altogether, our data provide an explanation for low HK3 and KLF5 (show KLF5 Proteins) expression in particular AML (show RUNX1 Proteins) subtype and establish these genes as novel CEBPA (show CEBPA Proteins) targets during neutrophil differentiation.
HK3 is: (1) directly activated by PU.1, (2) repressed by PML (show PML Proteins)-RARA (show RARA Proteins), and (3) functionally involved in neutrophil differentiation and cell viability of acute promyelocytic leukemia (show PML Proteins) cells.
Data demonstrated that in addition to galectin-3 (show LGALS3 Proteins), HK III and cyclin A (show CCNA2 Proteins) profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.
Data show that HKIII exerts protective effects against oxidative stress, perhaps by increasing ATP levels, reducing oxidant-induced ROS (show ROS1 Proteins) production, preserving mitochondrial membrane potential, and increasing mitochondrial biogenesis.
The expression pattern of HK3 is reported in newly diagnosed esophageal adenocarcinoma by means of immunohistochemistry.
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate.
hexokinase 3 (white cell)
, hexokinase type III
, ATP:D-hexose 6-phosphotransferase
, HK III