Browse our NADPH Oxidase 4 Proteins (NOX4)

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NADPH Oxidase 4 Proteins (NOX4)
On are 13 NADPH Oxidase 4 (NOX4) Proteins from 4 different suppliers available. Additionally we are shipping NADPH Oxidase 4 Antibodies (182) and NADPH Oxidase 4 Kits (24) and many more products for this protein. A total of 226 NADPH Oxidase 4 products are currently listed.
AI648021, KOX, KOX-1, NOX4, RENOX
list all proteins Gene Name GeneID UniProt
NOX4 50507 Q9NPH5
NOX4 50490 Q9JHI8
NOX4 85431 Q924V1

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NADPH Oxidase 4 Proteins (NOX4) by Origin

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More Proteins for NADPH Oxidase 4 Interaction Partners

Human NADPH Oxidase 4 (NOX4) interaction partners

  1. data suggest that monocytic Nox4 is a central regulator of actin dynamics, and induction of Nox4 is the rate-limiting step in metabolic stress-induced monocyte priming and dysfunction associated with accelerated atherosclerosis and the progression of atherosclerotic plaques

  2. findings demonstrate that manipulation of the host PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) signaling pathway and Nox4 gene expression is a novel mechanism involved in T. gondii survival and proliferation

  3. Loss of NOX4 increases actomyosin levels and favours an epithelial to amoeboid transition contributing to tumour aggressiveness.

  4. NOX2 (show CYBB Proteins), NOX4, and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 (show ANGPT1 Proteins) signaling and angiogenic responses in endothelial cells.

  5. Mechanistically, HO-1 (show HMOX1 Proteins) induction by all CRLPs requires NADPH oxidase 4, with PUFA-containing particles additionally dependent upon mitochondrial reactive oxygen species.These studies define new molecular pathways coupling endothelial cell activation by model CMRs with adaptive regulation of Nrf2 (show GABPA Proteins)-dependent HO-1 (show HMOX1 Proteins) expression

  6. NOX4 knockout cell lines showed reduced cell proliferation with an increase of sub-G1 cell population and the decrease of S/G2 (show STRN3 Proteins)/M population, and resulted in a dramatic decrease in invadopodium formation and the invasive activity. NOX4 deficiency caused a decrease in focal adhesions and cell migration in HeLa cells. The results suggest that NOX4 is required for both efficient proliferation and invasion of HeLa cells.

  7. Thioredoxin (show TXN Proteins) attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2 (show CYBB Proteins)-NOX4 activity.

  8. Nox4-derived H2O2 in part activates Nox2 (show CYBB Proteins) to increase mitochondrial ROS (show ROS1 Proteins) via pSer36-p66Shc (show SHC1 Proteins), thereby enhancing VEGFR2 (show KDR Proteins) signaling and angiogenesis in endothelial cells.

  9. TGF-beta1 (show TGFB1 Proteins) increases NADPH oxidase 4 (NOX4) mRNA and protein expression in normal human lung fibroblasts (NHLFs) and causes nuclear export of HDAC4 (show HDAC4 Proteins).

  10. Nox4 should contribute to the pathological processes insubarachnoid hemorrhage(SAH (show ACSM3 Proteins))-induced early brain injury (EBI (show TBL1X Proteins)), and there was not an overlay effect of Nox2 (show CYBB Proteins) inhibition and Nox4 inhibition on preventing SAH (show ACSM3 Proteins)-induced EBI (show TBL1X Proteins).

Cow (Bovine) NADPH Oxidase 4 (NOX4) interaction partners

  1. Peroxide derived from superoxide generated by Nox4 appears to maintain a basal relaxation in bovine pulmonary arteries under normoxic conditions, which is removed under hypoxia leading to hypoxic pulmonary vasoconstriction.

Rabbit NADPH Oxidase 4 (NOX4) interaction partners

  1. proteasome inhibition completely prevented endoplasmic reticulum stress-induced increase in NADPH oxidase (show NOX1 Proteins) activity, as well as increases in Nox4 isoform and protein disulfide isomerase (show P4HB Proteins) mRNA expression

Mouse (Murine) NADPH Oxidase 4 (NOX4) interaction partners

  1. Nox2 (show CYBB Proteins)- and Nox4-derived reactive oxygen species contribute to stem cell pluripotency maintenance and self-renewal.

  2. FYN (show FYN Proteins) is activated by oxidative stress and serves as a negative feedback regulator of NOX4 in cardiomyocytes during cardiac remodeling

  3. NOX4-derived reactive oxygen species in general, and possibly superoxide in particular, are involved in flow-stimulated inner medullary collecting duct ET-1 (show EDN1 Proteins) production.

  4. CYLD (show CYLD Proteins) contributes to the transdifferentiation of adventitial fibroblasts via deubiquitinating Nox4 and may play a role in vascular remodeling.

  5. Data suggests that ROS (show ROS1 Proteins) produced during primitive endoderm differentiation is dependent in part on increased NOX1 (show NOX1 Proteins) and NOX4 levels, which is under the control of GATA6 (show GATA6 Proteins). Furthermore, these results suggest that the combined activity of multiple NOX proteins is necessary for the differentiation of F9 cells to primitive endoderm.

  6. Nox4 is upregulated in pericytes in peri (show POSTN Proteins)-infarct areas after acute brain ischemia and may enhance blood-brain barrier breakdown through activation of NFkappaB and matrix metalloproteinase 9 (show MMP9 Proteins), thereby causing enlargement of infarct volume.

  7. Deficiency of NOX4 resulted in reduced expression of carnitine palmitoyltransferase 1A (CPT1A (show CPT1A Proteins)), which is a key mitochondrial enzyme in the fatty acid oxidation (FAO) pathway. The reduced FAO resulted in less activation of the nucleotide-binding domain, leucine-rich-repeat-containing receptor (NLR (show CXCR5 Proteins)), pyrin-domain-containing 3 (NLRP3 (show NLRP3 Proteins)) inflammasome in macrophages.

  8. NOX4- and NOX1 (show NOX1 Proteins)-derived ROS (show ROS1 Proteins) contribute to atherosclerosis in the aortic sinus of diabetic ApoE (show APOE Proteins) knockout mice.

  9. CD44V6 is part of a positive-feedback loop with TGFbeta1 (show TGFB1 Proteins)/TGFbetaRI signaling that acts to increase NOX4/ROS (show ROS1 Proteins) production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.

  10. Nox4 mitigates cerebral artery structural changes in a murine model of Marfan syndrome.

Pig (Porcine) NADPH Oxidase 4 (NOX4) interaction partners

  1. MRTF down-regulation/inhibition suppresses TGFbeta (show TGFB1 Proteins)/contact disruption-provoked Nox4 protein and mRNA expression, Nox4 promoter activation, and reactive oxygen species production.

  2. Nox4 NADPH oxidase (show NOX1 Proteins) mediates oxidative stress and apoptosis caused by TNF-alpha (show TNF Proteins) in cerebral vascular endothelial cells.

  3. Nox4 NADPH oxidase (show NOX1 Proteins)-derived reactive oxygen species also initiate a cell survival mechanism by increasing production of carbon monoxide by constitutive heme oxygenase-2 (show HMOX2 Proteins).

NADPH Oxidase 4 (NOX4) Protein Profile

Protein Summary

This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with NADPH Oxidase 4 (NOX4)

  • NADPH oxidase 4 (NOX4)
  • NADPH oxidase 4 (nox4)
  • NADPH oxidase 4 (PTRG_09562)
  • NADPH oxidase 4 (Nox4)
  • AI648021 protein
  • KOX protein
  • KOX-1 protein
  • NOX4 protein
  • RENOX protein

Protein level used designations for NADPH Oxidase 4 Proteins (NOX4)

NADPH oxidase 4 , predicted NADPH oxidase-4 , kidney oxidase-1 , kidney superoxide-producing NADPH oxidase , renal NAD(P)H-oxidase , KOX-1 , superoxide-generating NADPH oxidase 4 , kox-1

419012 Gallus gallus
619226 Ciona intestinalis
705931 Macaca mulatta
735636 Pan troglodytes
6347852 Pyrenophora tritici-repentis Pt-1C-BFP
50507 Homo sapiens
378474 Bos taurus
100034665 Ovis aries
100339697 Oryctolagus cuniculus
50490 Mus musculus
85431 Rattus norvegicus
100523323 Sus scrofa
485144 Canis lupus familiaris
100171782 Pongo abelii
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