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these findings demonstrate that Trx1 is a critical regulator of necroptosis that suppresses cell death by maintaining MLKL in a reduced inactive state.
Study shows that TRX1 (show MLL Antibodies) and APEX1 (show APEX1 Antibodies) expressions are up regulated in new Multiple Sclerosis (MS) patients compared to controls and might be implicated in pathogenesis of the disease.
CD40 (show CD40 Antibodies) activation resulted in down-regulation of Thioredoxin (Trx)-1 (show TXN Antibodies) to permit ASK1 (show MAP3K5 Antibodies) activation and apoptosis. Although soluble receptor (show IFNAR1 Antibodies) agonist alone could not induce death, combinatorial treatment incorporating soluble CD40 (show CD40 Antibodies) agonist and pharmacological inhibition of Trx-1 (show MLL Antibodies) was functionally equivalent to the signal triggered by mCD40L
our findings identify the TXN (show TXN Antibodies)-FOXO1 (show FOXO1 Antibodies)-p300 (show EP300 Antibodies) circuit as the sensor and effector of oxidative stress in DLBCL cells
Novel positive feedback loop between Trx-1 (show MLL Antibodies) and S100P (show S100P Antibodies) promotes colorectal cancer invasion and metastasis.
Thioredoxin (show TXN Antibodies) attenuates oxidized low-density lipoprotein induced oxidative stress in human umbilical vein endothelial cells by reducing NOX2 (show CYBB Antibodies)-NOX4 (show NOX4 Antibodies) activity.
from the two catalytic cysteines of TRX1 (show MLL Antibodies) the residue C32 (show CKLF Antibodies) is responsible for the high-affinity binding of TRX1 (show MLL Antibodies) to the ASK1 (show MAP3K5 Antibodies)-TRX (show VAC14 Antibodies)-binding domain in reducing conditions
findings suggest that the up-regulated RRM1 (show RRM1 Antibodies) and hTrx1 (show MLL Antibodies) in colorectal cancer directly interact with each other and promote RR activity, resulting in enhanced DNA synthesis and cancer malignancy.
findings support the potential pathophysiological relevance of TRX (show VAC14 Antibodies) in celiac disease and establish the Cys (show DNAJC5 Antibodies)(370)-Cys (show DNAJC5 Antibodies)(371) disulfide bond of TG2 (show TGM2 Antibodies) as one of clearest examples of an allosteric disulfide bond in mammals.
Trx (show VAC14 Antibodies) and its target proteins involved in redox signaling are critical for the control of cell fate such as cell survival and apoptosis [review]
Thus, VAC14 (show VAC14 Antibodies), PI(3,5)P(2) and/or PI(5)P play a role in controlling postsynaptic function via regulation of endocytic cycling of AMPA (show GRIA3 Antibodies) receptors.
a novel regulatory mechanism whereby ArPIKfyve (show VAC14 Antibodies) enhances Sac3 (show FIG4 Antibodies) abundance by attenuating Sac3 (show FIG4 Antibodies) proteasome-dependent degradation and suggest that a failure of this mechanism could be the primary molecular defect in the pathogenesis of CMT4J.
The data demonstrate for the first time a physical association between functionally related PIKfyve (show PIKFYVE Antibodies) and ArPIKfyve (show VAC14 Antibodies) in 3T3-L1 adipocytes.
report the characterization of a mouse mutant lacking Vac14 (show VAC14 Antibodies), a regulator of PI(3,5)P(2) synthesis
The authors show that Vac14 (show VAC14 Antibodies) exerts an effect as a scaffold for the PI(3,5)P2 regulatory complex by direct contact with the known regulators of PI(3,5)P2: Fig4 (show FIG4 Antibodies), Fab1, Vac7 and Atg18 (show WIPI1 Antibodies).
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.
, ATL-derived factor
, TXN delta 3
, surface-associated sulphydryl protein
, thioredoxin delta 3
, Tax1 (human T-cell leukemia virus type I) binding protein 1
, Tax1 (human T-cell leukemia virus type I) binding protein 2
, protein VAC14 homolog
, vacuole morphology 14