TXN antibody (C-Term)

Catalog No. ABIN1881960

Product Details anti-TXN Antibody

Target: TXN (Thioredoxin (TXN))

Binding Specificity: AA 66-94, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXN antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, M, Pig, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN.

Clone: RB42816

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-TXN antibody (ABIN1881960)

Zheng, Ma, Sun, Yin, Lin, Liu, Xu, Zeng: "Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity." in: Redox biology, Vol. 14, pp. 237-249, (2018) (PubMed).

Target Details for TXN

Target: TXN (Thioredoxin (TXN))

Alternative Name: TXN (TXN Products)

Synonyms: TRDX antibody, TRX antibody, TRX1 antibody, ADF antibody, AW550880 antibody, Trx1 antibody, Txn antibody, trx antibody, TXN antibody, SCM1.18 antibody, trxA3 antibody, thioredoxin antibody, TR-1 antibody, Trx-1 antibody, thioredoxin antibody, thioredoxin 1 antibody, thioredoxin L homeolog antibody, similar to 44RRORF109c hypothetical protein; similar to bacterial thioredoxin (SwissProt P06544) antibody, thioredoxin pseudogene antibody, cytosolic thioredoxin Trx1 antibody, TXN antibody, Txn1 antibody, txn.L antibody, txn antibody, trx antibody, SCO0885 antibody, PHG25ORF099c antibody, LOC100349046 antibody, Txn antibody, trx1 antibody

Background: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).

Molecular Weight: 11737

NCBI Accession: NP_001231867, NP_003320

UniProt: P10599

Pathways: Carbohydrate Homeostasis, Cell RedoxHomeostasis