Browse our APP Proteins (APP)

Full name:
Amyloid beta (A4) Precursor Protein Proteins (APP)
On www.antibodies-online.com are 46 Amyloid beta (A4) Precursor Protein (APP) Proteins from 11 different suppliers available. Additionally we are shipping APP Antibodies (917) and APP Kits (107) and many more products for this protein. A total of 1105 APP products are currently listed.
Synonyms:
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740
list all proteins Gene Name GeneID UniProt
APP 351 P05067
APP 11820 P12023
APP 54226 P08592

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APP Proteins (APP) by Origin

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Top referenced APP Proteins

  1. Human APP Protein expressed in Human Cells - ABIN2003274 : Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. in Nature 2009 (PubMed)
    Show all 5 references for 2003274

  2. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN2003278 : Walter, Mason, Mason: Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions. in Biochemical and biophysical research communications 1997 (PubMed)
    Show all 5 references for 2003278

  3. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN1098609 : Kontush: Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins. in Cellular and molecular neurobiology 2001 (PubMed)
    Show all 2 references for 1098609

  4. Human APP Protein expressed in HEK-293 Cells - ABIN2714676 : Planque, Nishiyama, Sonoda, Lin, Taguchi, Hara, Kolodziej, Mitsuda, Gonzalez, Sait, Fukuchi, Massey, Friedland, ONuallain, Sigurdsson, Paul: Specific amyloid β clearance by a catalytic antibody construct. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (show GRIN2A Proteins) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (show WNT4 Proteins)-PCP (show PRCP Proteins) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 Proteins) pathway through a mechanism mediated by PntP2 (show ETS2 Proteins).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (show IAPP Proteins) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 Proteins)) reduces amyloid-beta production by altering Nicastrin (show NCSTN Proteins) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (show MAPK8 Proteins) signaling in neurons and induction of JNK (show MAPK8 Proteins) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. The search for the genetic factors contributing to Alzheimer disease (AD) has evolved tremendously throughout the years. It started from the discovery of fully penetrant mutations in Amyloid precursor protein, Presenilin 1 (show PSEN1 Proteins), and Presenilin 2 (show PSEN2 Proteins) as a cause of autosomal dominant AD

  2. The authors now show that the very little Abeta generated by PS1 (show PSEN1 Proteins) L435F mutant consists primarily of Abeta43, a highly amyloidogenic species which was overlooked in previous studies of this mutant.

  3. Complicated function of dopamine in Abeta-related neurotoxicity: Dual interactions with Tyr (show TYR Proteins)(10) and SNK (show ATP1A4 Proteins)(26-28) of Abeta

  4. These studies support the hypothesis that the ratio of Abeta monomers to Abeta oligomers is a critical factor that regulates synapse damage.

  5. UBQLN4 (show UBQLN4 Proteins), APP, CTNNB1 (show CTNNB1 Proteins), SHBG (show SHBG Proteins), and COL1A1 (show COL1A1 Proteins) might be involved in the development of nonalcoholic fatty liver disease, and are proposed as the potential markers for predicting the development of this condition

  6. Fe65 (show APBB1 Proteins) is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 (show APBB1 Proteins) constructs expressed in human neuroblastoma (show ARHGEF16 Proteins) cells. Our results indicate that PTB2 (show PTBP1 Proteins) rather than the WW domain is important for the nuclear localization of Fe65 (show APBB1 Proteins).

  7. bis (show BAG3 Proteins)(sulfosuccinimidyl) suberate (BS3) was used to cross-link Abeta1-42 oligomers prior to electrophoresis. When compared to a previously reported Abeta cross-linking agent, glutaraldehyde, it was quite apparent that BS3 is more suitable for detecting intra-membrane Abeta oligomers and extra-membrane Abeta oligomers states.

  8. This is the first report to show decreased Amyloid beta levels in plasma in Amyloid beta Precursor Protein A673T carriers and thus provides evidence that lower Abeta levels throughout life may be protective against Alzheimer Disease.

  9. APP + PS1 (show PSEN1 Proteins) double transgenic rats had altered serum Abeta42 and Abeta42/Abeta40 levels, brain histopathology and cognitive behavior. APP rat brain had many histopathogical abnormalities that are often seen in Alzheimer's disease brains, but their memory did not show significant impairment during the behavioral testing. APP + PS1 (show PSEN1 Proteins) rats showed brain pathology as well as reduced memory retention compared to the APP and the ...

  10. common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to beta-amyloid (Abeta). Because Abeta and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory.

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Proteins)- and CD47 (show CD47 Proteins)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE Proteins) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. APP and its metabolites are capable of influencing the basic physiology of the pancreas.

  2. treatment of APP/E4/Abca1+/- mice with liver X receptor (LXR) agonist T0 ameliorates APOE4-induced Alzheimer's disease (AD)-like pathology and therefore targeting the LXR-ABCA1-APOE regulatory axis could be effective as a potential therapeutic approach in AD patients, carriers of APOEepsilon4

  3. These results provide evidence supporting a key role for the p38 MAPK (show MAPK14 Proteins) signaling pathway which is involved in the regulation of Abeta1-42 internalization in the parietal cortex and hippocampus of mouse through LRP1 (show LRP1 Proteins) in vivo.

  4. increased APP and/or beta-CTF impact the endocytic pathway to disrupt NGF trafficking and signaling, resulting in trophic deficits in basal forebrain cholinergic neurons.

  5. ABETA 25-35 downregulated miR (show MLXIP Proteins)-137 and upregulated TNFAIP1 (show TNFAIP1 Proteins) in cortical neurons and N2a cells.

  6. These results indicate that platelet APP limits venous thromboembolism through a negative regulation of both fibrin formation and neutrophil function.

  7. These findings highlight for the first time that APP-dependent glial cell line-derived neurotropic factor expression drives the process of neuromuscular junction formation, providing new insights into the link between APP gene regulatory network and physiologic functions.

  8. TREM2 (show TREM2 Proteins) protects from Alzheimer's disease by enabling microglia to surround and alter Abeta plaque structure, thereby limiting neuritic damage.

  9. To conclude, our data corroborate a major role of APP for structural plasticity and adaptive remodeling of cortical synapses in the adult brain. They also indicate that lack of APP holoprotein leads to impaired D-serine homeostasis, which is associated with dysfunctional synaptic plasticity.

  10. Pretreatment with a P-glycoprotein inhibitor, which blocks blood-brain barrier transport of Abeta, resulted in significant prolongation of Abeta40 half-life, but only in the latter phase of Abeta clearance from the interstitial fluid.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 Proteins)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP Proteins) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 Proteins) and Aplp2 (show APLP2 Proteins) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 Proteins)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 Proteins) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 Proteins) signaling

APP Protein Profile

Protein Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl)
  • amyloid beta (A4) precursor protein (APP)
  • amyloid beta (A4) precursor protein (app)
  • amyloid beta (A4) precursor protein (App)
  • amyloid beta (A4) precursor protein a (appa)
  • beta amyloid protein precursor (LOC100009546)
  • AAA protein
  • ABETA protein
  • Abpp protein
  • AD1 protein
  • Adap protein
  • Ag protein
  • app protein
  • APP-like protein
  • APPI protein
  • appl protein
  • BcDNA:GH04413 protein
  • betaApp protein
  • CG7727 protein
  • CTFgamma protein
  • Cvap protein
  • Dmel\\CG7727 protein
  • E030013M08Rik protein
  • EG:65F1.5 protein
  • PN-II protein
  • PN2 protein
  • wu:fj34d10 protein
  • wu:fk65e12 protein
  • zgc:85740 protein

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

GENE ID SPECIES
31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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