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Browse our APP Proteins (APP)

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Amyloid beta (A4) Precursor Protein Proteins (APP)
On are 46 Amyloid beta (A4) Precursor Protein (APP) Proteins from 11 different suppliers available. Additionally we are shipping APP Antibodies (849) and APP Kits (103) and many more products for this protein. A total of 1033 APP products are currently listed.
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740
list all proteins Gene Name GeneID UniProt
APP 351 P05067
APP 11820 P12023
APP 54226 P08592

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APP Proteins (APP) by Origin

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Top referenced APP Proteins

  1. Human APP Protein expressed in Human Cells - ABIN2003274 : Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. in Nature 2009 (PubMed)
    Show all 5 references for ABIN2003274

  2. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN2003280 : Walter, Mason, Mason: Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions. in Biochemical and biophysical research communications 1997 (PubMed)
    Show all 5 references for ABIN2003280

  3. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN1098609 : Kontush: Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins. in Cellular and molecular neurobiology 2001 (PubMed)
    Show all 2 references for ABIN1098609

  4. Human APP Protein expressed in HEK-293 Cells - ABIN2714676 : Planque, Nishiyama, Sonoda, Lin, Taguchi, Hara, Kolodziej, Mitsuda, Gonzalez, Sait, Fukuchi, Massey, Friedland, ONuallain, Sigurdsson, Paul: Specific amyloid β clearance by a catalytic antibody construct. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (show GRIN2A Proteins) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (show WNT4 Proteins)-PCP (show PRCP Proteins) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 Proteins) pathway through a mechanism mediated by PntP2 (show ETS2 Proteins).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (show IAPP Proteins) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 Proteins)) reduces amyloid-beta production by altering Nicastrin (show NCSTN Proteins) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (show MAPK8 Proteins) signaling in neurons and induction of JNK (show MAPK8 Proteins) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. in vitro BACE1 (show BACE Proteins)-activity assays demonstrate that palmitoylation-dependent dimerization of APP promotes beta-cleavage of APP in lipid-rich detergent resistant cell membranes (DRMs), when compared to total APP.

  2. Mitochondria are devoid of amyloid beta-protein-producing secretases; the evidence presented for unlikely occurrence within mitochondria of amyloid beta generation from amyloid precursor protein.

  3. Familial Alzheimer's Disease mutations falling within the Amyloid Precursor Protein sequence lead to dramatic changes in aggregation kinetics and influence the ability of Amyloid-beta Peptide to form immunologically and morphologically distinct amyloid structures.

  4. Data show that presenilin 1 (PS1 (show PSEN1 Proteins))/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2 (show PSEN2 Proteins))/Aph1aL, PS2 (show PSEN2 Proteins)/Aph1aS and PS2 (show PSEN2 Proteins)/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases.

  5. The circular RNA ciRS-7 promotes APP and BACE1 (show BACE Proteins) degradation in an NF-kappaB (show NFKB1 Proteins)-dependent manner.

  6. All binary complexes (KLC1 (show KLC1 Proteins):APP, KLC1 (show KLC1 Proteins):JIP1 (show MAPK8IP1 Proteins), and APP:JIP1) contain conformations with favorable binding free energies indicating that KLC1 (show KLC1 Proteins) and JIP1 (show MAPK8IP1 Proteins) may take part in APP transport in Alzheimer's disease patients.

  7. Our findings provide evidence that induction of APP shedding via Ang II (show AGT Proteins)/AT1 receptor (show AGTRAP Proteins) stimulation is effected by G protein activation with Gbg (show CFB Proteins) subunits playing important roles.

  8. aggregating proteins, such as amyloid-beta (Abeta) and alpha-synuclein (alpha-syn), proteins associated with Alzheimer's disease and synucleinopathies, respectively, share similar biophysical and biochemical properties with PrP (show C4BPA Proteins)(Sc) that influence-{REVIEW}

  9. The overexpression of MTERF4 induced a significant increase in the levels of APP protei (show PSEN1 Proteins)n and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease.

  10. findings demonstrate that only Abeta(1-42) contains unique structural features that facilitate membrane insertion and channel formation, now aligning ion channel formation with the differential neurotoxic effect of Abeta(1-40) and Abeta(1-42) in Alzheimer's disease.

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Proteins)- and CD47 (show CD47 Proteins)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE Proteins) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. The levels of MTERF4 protein were significantly increased in the hippocampus of APP/PS1 (show PSEN1 Proteins) mice, an animal model of Alzheimer's disease.

  2. The results indicate that Nrx2alpha and NL1 (show MMEL1 Proteins) are targets of Abeta oligomers and that prevention of this interaction reduces the deleterious impact of Abeta oligomers on synapses and cognition.

  3. These results support a role for APP in cortical lamination and demonstrate the utility of a conditional knockout approach in which APP can be deleted with temporal control in vivo.

  4. NGF (show NGFB Proteins) signalling directly controls basal APP phosphorylation, subcellular localization and BACE (show BACE Proteins) cleavage.

  5. Therefore, SORL1 (show SORL1 Proteins) activation by 6-shogaol provides neuronal cell survival through the inhibition of Abeta production. These results indicate that 6-shogaol should be regarded as an SORL1 (show SORL1 Proteins) activator and a potential preventive agent for the treatment of AD.

  6. Abeta monomers physiologically favor Tau activity and dendritic sprouting, whereas their excess causes Tau pathology

  7. analysis suggests that some familial Alzheimer's disease mutations in APP are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 (show BACE Proteins) cleavage sites

  8. results suggest that COX (show CPOX Proteins) activity and amyloid deposition in brain are likely independent processes.

  9. Ln-gamma1 promotes internalization of PrPC (show PRNP Proteins) and mGluR5 (show GRM5 Proteins) and transiently decreases AbetaO biding to neurons; however, the peptide does not impact AbetaO toxicity. Given that mGluR5 (show GRM5 Proteins) is critical for toxic signaling by AbetaOs and in prion (show PRNP Proteins) diseases, we tested whether mGlur5 (show GRM5 Proteins) knock-out mice would be susceptible to prion (show PRNP Proteins) infection.

  10. prion protein (show PRNP Proteins)-derived cell-penetrating peptide cytotoxicity is modulated by pH but independent of amyloid formation

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 Proteins)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP Proteins) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 Proteins) and Aplp2 (show APLP2 Proteins) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 Proteins)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 Proteins) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 Proteins) signaling

APP Protein Profile

Protein Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl)
  • amyloid beta (A4) precursor protein (APP)
  • amyloid beta (A4) precursor protein (app)
  • amyloid beta (A4) precursor protein (App)
  • amyloid beta (A4) precursor protein a (appa)
  • beta amyloid protein precursor (LOC100009546)
  • AAA protein
  • ABETA protein
  • Abpp protein
  • AD1 protein
  • Adap protein
  • Ag protein
  • app protein
  • APP-like protein
  • APPI protein
  • appl protein
  • BcDNA:GH04413 protein
  • betaApp protein
  • CG7727 protein
  • CTFgamma protein
  • Cvap protein
  • Dmel\\CG7727 protein
  • E030013M08Rik protein
  • EG:65F1.5 protein
  • PN-II protein
  • PN2 protein
  • wu:fj34d10 protein
  • wu:fk65e12 protein
  • zgc:85740 protein

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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