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Browse our APP Proteins (APP)

Full name:
Amyloid beta (A4) Precursor Protein Proteins (APP)
On are 46 Amyloid beta (A4) Precursor Protein (APP) Proteins from 11 different suppliers available. Additionally we are shipping APP Antibodies (849) and APP Kits (97) and many more products for this protein. A total of 1027 APP products are currently listed.
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740
list all proteins Gene Name GeneID UniProt
APP 351 P05067
APP 11820 P12023
APP 54226 P08592

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APP Proteins (APP) by Origin

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Top referenced APP Proteins

  1. Human APP Protein expressed in Human Cells - ABIN2003274 : Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. in Nature 2009 (PubMed)
    Show all 5 references for ABIN2003274

  2. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN2003280 : Walter, Mason, Mason: Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions. in Biochemical and biophysical research communications 1997 (PubMed)
    Show all 5 references for ABIN2003280

  3. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN1098609 : Kontush: Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins. in Cellular and molecular neurobiology 2001 (PubMed)
    Show all 2 references for ABIN1098609

  4. Human APP Protein expressed in HEK-293 Cells - ABIN2714676 : Planque, Nishiyama, Sonoda, Lin, Taguchi, Hara, Kolodziej, Mitsuda, Gonzalez, Sait, Fukuchi, Massey, Friedland, ONuallain, Sigurdsson, Paul: Specific amyloid β clearance by a catalytic antibody construct. in The Journal of biological chemistry 2015 (PubMed)

More Proteins for APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Appl siRNA inhibition in cortex glia resulted in longer sleep and reduced expression of genes involved in glutamate (show GRIN2A Proteins) recycling.

  2. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  3. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  4. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  5. APPL is the first example of a modulator of the Wnt (show WNT4 Proteins)-PCP (show PRCP Proteins) pathway specifically required for axon outgrowth.

  6. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 Proteins) pathway through a mechanism mediated by PntP2 (show ETS2 Proteins).

  7. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  8. Disruption of amyloid protein (show IAPP Proteins) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  9. Down-regulation of the ATP-binding cassette transporter 2 (Abca2 (show ABCA2 Proteins)) reduces amyloid-beta production by altering Nicastrin (show NCSTN Proteins) maturation and intracellular localization.

  10. accumulation of Ass42 plaques induces JNK (show MAPK8 Proteins) signaling in neurons and induction of JNK (show MAPK8 Proteins) contributes to Ass42 mediated cell death

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Data describe a novel signal transduction pathway in neurons whereby ApoE activates a non-canonical MAP kinase cascade that enhances APP transcription and amyloid-beta synthesis; using embryonic stem cell-derived human neurons, show that ApoE secreted by glia stimulates neuronal Abeta production with an ApoE4 > ApoE3 > ApoE2 potency rank order.

  2. Han Chinese EOFAD patients carrying the APPV717I mutation exhibited a specific clinical phenotype that was mainly characterized by prominent early affective symptoms, executive dysfunction, and disorientation in their 50s, as well as frequent late spastic paraparesis and cerebellar ataxia (show USP14 Proteins) compared with Western reports

  3. APP mutations are associated with specific AD phenotype.

  4. High-affinity binding of amyloid-beta protein (Abeta) Abeta(1-40) to GM1 containing nanodiscs, with dissociation constants, KD, in the range from 25 to 41 nM, in a ganglioside GM1 concentration-dependent manner.

  5. analysis suggests that some familial Alzheimer's disease mutations in APP are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 (show BACE Proteins) cleavage sites

  6. This review reveled that Mutations in APP and PS-1 (show PSEN1 Proteins) and PS-2 (show PSEN2 Proteins) genes that are associated with early-onset, autosomal, dominantly inherited AD

  7. glycoprotein quality control-related proteins have strong affinity for Abeta monomers.

  8. APP does not modulate Orai-dependent store-operated calcium entry following quantitative calcium store depletion.

  9. RHBDL4 (show RHBDL3 Proteins)-mediated APP processing provides insight into APP and rhomboid physiology and qualifies for further investigations to elaborate its impact on Alzheimer disease pathology.

  10. The data suggest that miR (show MLXIP Proteins)-106b inhibits Amyloid-beta (1-42)-induced tau phosphorylation at Tyrosine 18 by targeting Fyn (show FYN Proteins).

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Proteins)- and CD47 (show CD47 Proteins)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE Proteins) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. This study describes Abeta deposition in 102 clinically characterized cattle brains from animals aged 0 to 20 years, demonstrates certain similarities between Abeta deposition patterns exhibited in cattle brains and those in the human brain in early stages of aging

  2. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. analysis suggests that some familial Alzheimer's disease mutations in APP are amyloidogenic and/or amyloidolytic via selection of alternative BACE1 (show BACE Proteins) cleavage sites

  2. results suggest that COX (show CPOX Proteins) activity and amyloid deposition in brain are likely independent processes.

  3. Ln-gamma1 promotes internalization of PrPC (show PRNP Proteins) and mGluR5 (show GRM5 Proteins) and transiently decreases AbetaO biding to neurons; however, the peptide does not impact AbetaO toxicity. Given that mGluR5 (show GRM5 Proteins) is critical for toxic signaling by AbetaOs and in prion (show PRNP Proteins) diseases, we tested whether mGlur5 (show GRM5 Proteins) knock-out mice would be susceptible to prion (show PRNP Proteins) infection.

  4. prion protein (show PRNP Proteins)-derived cell-penetrating peptide cytotoxicity is modulated by pH but independent of amyloid formation

  5. This study further distinguishes two separate Abetao-dependent signaling cascades, one dependent on extracellular Ca(2 (show CA2 Proteins)+) and Fyn (show FYN Proteins) kinase activation and the other dependent on the release of Ca(2 (show CA2 Proteins)+) from intracellular stores. Thus, Abetao triggers multiple distinct PrP(C (show PRNP Proteins))-mGluR5 (show GRM5 Proteins)-dependent events implicated in neurodegeneration and dementia.

  6. APP shares essential functions with APP-like protein-2 (APLP2 (show APLP2 Proteins)) but not APP-like protein-1 (APLP1 (show APLP1 Proteins)). Noteworthy, APLP2 (show APLP2 Proteins), but not APLP1 (show APLP1 Proteins), interacts with Stub1 (show STUB1 Proteins) and CRL4(CRBN (show CRBN Proteins)), pointing to a functional pathway shared only by APP and APLP2 (show APLP2 Proteins).

  7. Orthopedic surgery induces Abeta accumulation and tau phosphorylation in the hippocampus.

  8. Results indicate that isomerization of Asp7 and phosphorylation of Ser8 of the amyloid beta peptide (Abeta) backbone have a significant impact on the profiles of brain Abeta binding proteins.

  9. Cadmium induces cell death on cholinergic neurons through blockade of M1 receptor, overexpression of AChE-S and GSK-3beta, down-regulation of AChE-R and increase in Abeta and total and phosphorylated tau protein levels.

  10. plasma Abeta(1-42) concentration increases with age, while the concentration of Abeta(1-42) in the cerebrospinal fluid (CSF (show CSF2 Proteins)) decreases in APPswe, PS1M146V and TauP301L transgenic (3xTg-AD) mice.

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 Proteins)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP Proteins) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 Proteins) and Aplp2 (show APLP2 Proteins) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 Proteins)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 Proteins) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 Proteins) signaling

APP Protein Profile

Protein Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl)
  • amyloid beta (A4) precursor protein (APP)
  • amyloid beta (A4) precursor protein (app)
  • amyloid beta (A4) precursor protein (App)
  • amyloid beta (A4) precursor protein a (appa)
  • beta amyloid protein precursor (LOC100009546)
  • AAA protein
  • ABETA protein
  • Abpp protein
  • AD1 protein
  • Adap protein
  • Ag protein
  • app protein
  • APP-like protein
  • APPI protein
  • appl protein
  • BcDNA:GH04413 protein
  • betaApp protein
  • CG7727 protein
  • CTFgamma protein
  • Cvap protein
  • Dmel\\CG7727 protein
  • E030013M08Rik protein
  • EG:65F1.5 protein
  • PN-II protein
  • PN2 protein
  • wu:fj34d10 protein
  • wu:fk65e12 protein
  • zgc:85740 protein

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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