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Browse our APP Proteins (APP)

Full name:
Amyloid beta (A4) Precursor Protein Proteins (APP)
On are 47 Amyloid beta (A4) Precursor Protein (APP) Proteins from 11 different suppliers available. Additionally we are shipping APP Antibodies (836) and APP Kits (107) and many more products for this protein. A total of 1062 APP products are currently listed.
AAA, ABETA, Abpp, AD1, Adap, Ag, app, APP-like, APPI, appl, BcDNA:GH04413, betaApp, CG7727, CTFgamma, Cvap, Dmel\\CG7727, E030013M08Rik, EG:65F1.5, PN-II, PN2, wu:fj34d10, wu:fk65e12, zgc:85740
list all proteins Gene Name GeneID UniProt
APP 351 P05067
APP 11820 P12023
APP 54226 P08592

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APP Proteins (APP) by Origin

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Top referenced APP Proteins

  1. Human APP Protein expressed in Human Cells - ABIN2003274 : Nikolaev, McLaughlin, OLeary, Tessier-Lavigne: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. in Nature 2009 (PubMed)
    Show all 5 references for ABIN2003274

  2. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN2003276 : Walter, Mason, Mason: Alzheimer's disease amyloid beta peptide 25-35 inhibits lipid peroxidation as a result of its membrane interactions. in Biochemical and biophysical research communications 1997 (PubMed)
    Show all 5 references for ABIN2003276

  3. Human APP Protein expressed in Escherichia coli (E. coli) - ABIN1098609 : Kontush: Alzheimer's amyloid-beta as a preventive antioxidant for brain lipoproteins. in Cellular and molecular neurobiology 2001 (PubMed)
    Show all 2 references for ABIN1098609

More Proteins for APP Interaction Partners

Fruit Fly (Drosophila melanogaster) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. memory is altered by two connected mechanisms-APPL loss-of-function and amyloid peptide toxicity-revealing in Drosophila a functional interaction between APPL and amyloid peptide.

  2. Our data demonstrate that, in addition to secreted APPL, the noncleaved form is involved in memory, raising the possibility that secreted and full-length APPL act together in memory processes.

  3. findings suggest that a normal function of presenilin (PS)is to repress kinesin-1 and dynein motor activity during axonal transport of amyloid precursor protein (APP) vesicles; perturbations of APP/PS transport could contribute to early neuropathology observed in Alzheimer's Disease

  4. APPL is the first example of a modulator of the Wnt (show WNT4 Proteins)-PCP (show PRCP Proteins) pathway specifically required for axon outgrowth.

  5. Data show that Appl is directly regulated by the Ras/MAPK (show MAPK1 Proteins) pathway through a mechanism mediated by PntP2 (show ETS2 Proteins).

  6. [review] APP-like proteins are involved in neuronal differentiation, neuritic outgrowth, and synapse formation.

  7. Disruption of amyloid protein (show IAPP Proteins) precursor (APP) proteins and specifically their soluble alpha-cleaved ectodomains can protect against progressive neurodegeneration in vivo.

  8. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-beta production by altering Nicastrin maturation and intracellular localization.

  9. accumulation of Ass42 plaques induces JNK (show MAPK8 Proteins) signaling in neurons and induction of JNK (show MAPK8 Proteins) contributes to Ass42 mediated cell death

  10. in adult flies, APPL is not required for learning but is specifically involved in long-term memory, a long lasting memory whose formation requires de novo protein synthesis and is thought to require synaptic structural plasticity.

Human Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Sporadic Abeta accumulation may be partly associated with increased amyloidogenic APP production, especially in APOE (show APOE Proteins) varepsilon4-negative subjects.

  2. Study identifies a common mechanism of transport into neurites of proteins linked to the pathology of Alzheimer's disease (i.e. sAPP) and ALS (show IGFALS Proteins) (i.e. FUS (show FUS Proteins), TDP-43 (show TARDBP Proteins) and SOD1 (show SOD1 Proteins))

  3. a considerable amount of evidence goes against the classical amyloid hypothesis and illustrates a new picture in which the Abeta loss of function, rather than its accumulation, has a pathogenic role in AD.

  4. The APP c.*331_*332del variant affected APP messenger RNA structure and binding of two microRNAs (miR (show MLXIP Proteins)-582-3p and miR (show MLXIP Proteins)-892b), providing a mechanism for the development of cerebral amyloid angiopathy.

  5. Astrocytic expression of the mutant APP is involved in the down-regulation of synaptic transmission in cell aging.

  6. Cell viability and ROS (show ROS1 Proteins) assays indicate that graphene oxide can indeed mitigate cytotoxicity of Abeta peptide amyloids.

  7. SPIONs with a positive charge have dual effects on the Abeta fibrillation process

  8. The conformational dynamics of large fatty acids derived oligomers (Abeta42) correlates with their ability to replicate and to induce apoptosis in human neuroblastoma (show ARHGEF16 Proteins) cells, with 12mers being more neurotoxic and prone to replication than 12-24mers.

  9. evaluated Abeta-induced DNA methylation (show HELLS Proteins) status of HMOX1 (show HMOX1 Proteins) at -374 promoter CpG site in blood samples from Alzheimer disease patients, patients with mild cognitive impairment, and control individuals

  10. findings may suggest that these multiple transporters/receptors and IDE (show IDE Proteins) expressed on the choroid plexus epithelium, ventricular ependymal cells and brain microvessels complementarily or cooperatively contribute to the clearance of amyloid-beta peptides from the brain

Pig (Porcine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid-beta inhibits No-cGMP signaling in a CD36 (show CD36 Proteins)- and CD47 (show CD47 Proteins)-dependent manner

  2. These experiments demonstrate the roles of Chol and ApoE (show APOE Proteins) in the modulation of membrane insertion of APP.

  3. Two novel transcript variants of porcine APP have been identified, producing isoforms of 695 and 751 amino acids, respectively.

  4. APP could be acting through a semaphorin receptor as well

Cow (Bovine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. release and aggregation of amyloid beta-peptide from brain lipid bilayers is regulated by cholesterol and GM1

Mouse (Murine) Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. EphB2 (show EPHB2 Proteins) prevents amyloid-beta-induced depletion of cell surface GluN1 (show GRIN1 Proteins) requiring the PDZ-binding motif of EphB2 (show EPHB2 Proteins).

  2. Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.

  3. the absence of Mt3 reduces Abeta uptake in astrocytes through an abnormality in actin polymerization.

  4. Mutant SOD1 Increases APP Expression and Phosphorylation in Cellular and Animal Models of ALS

  5. lactate levels remained elevated with age and increased aerobic glycolysis enzyme expression correlated with poorer memory performance in APP/PS1 (show PSEN1 Proteins) mice

  6. p38alpha (show MAPK14 Proteins) MAPK (show MAPK1 Proteins) plays a critical role in the regulation of BACE1 (show BACE Proteins) degradation and Abeta generation in Alzheimer Disease pathogenesis

  7. Swedish mutant APP-based BACE1 (show BACE Proteins) binding site peptide reduces APP beta-cleavage and cerebral Abeta levels in Alzheimer's mice.

  8. APP full length protein and/or its cleaved products are necessary to mount a complete and effective innate immune cell response to inflammatory injury.

  9. The study demonstrate that murine Abeta peptides have the capacity to produce amyloid deposits that are morphologically similar to deposits found in human AD provided the murine APP gene.

  10. Abeta oligomers in the cerebrospinal fluid (CSF (show CSF2 Proteins)) further promoted the expression of APH-1alpha/-1beta (by >2.5-fold), which enhances the gamma-cleavage of APP and Abeta deposition during AD progression

Xenopus laevis Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Report of biosynthesis of APP in physiological context and illuminate occurrence of two pools of APP, one of which is linked to neuroendocrine cell activation.

  2. A "CAGA (show S100A8 Proteins)" sequence proximal to the "ATG" start codon & immediately upstream of an interleukin-1-responsive element was found in a location unique to APP genes of amyloid plaque-forming species & absent in all other genes surveyed.

  3. endogenous cleavages at prohormone convertase-like sites in APP

Zebrafish Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. Amyloid beta precursor protein and prion protein (show PRNP Proteins) have a conserved interaction affecting cell adhesion and central nervous system development.

  2. A reduction in app levels causes defective axonal outgrowth of facial branchiomotor and spinal motor neurons, which involves disorganized axonal cytoskeletal elements.

  3. these results indicate the Appa-RFP (show MKRN1 Proteins) and Aplp2 (show APLP2 Proteins) fusion proteins are likely secreted from the central nervous system and accumulate in the embryonic veins independent of blood flow.

  4. Data show that knock down of APP in zebrafish results in fish with reduced body length and a short, curly tail, and that wild-type human APP rescues the morphant phenotype, but the Swedish mutant APP, which causes familial AD (fAD (show PSEN1 Proteins)), does not.

Rabbit Amyloid beta (A4) Precursor Protein (APP) interaction partners

  1. amyloid and oxidative stress-related disease proteins like Alzheimer A beta (show SUCLA2 Proteins) peptide are increased in expression and form localized accumulations in diabetic muscle in this rabbit model of diabetes.

  2. study suggests that hypercholesterolemia-induced Abeta accumulation may be mediated by 27-hydroxycholesterol, involving IGF-1 (show IGF1 Proteins) signaling

APP Protein Profile

Protein Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with APP

  • beta amyloid protein precursor-like (Appl)
  • amyloid beta (A4) precursor protein (APP)
  • amyloid beta (A4) precursor protein (app)
  • amyloid beta (A4) precursor protein (App)
  • amyloid beta (A4) precursor protein a (appa)
  • beta amyloid protein precursor (LOC100009546)
  • AAA protein
  • ABETA protein
  • Abpp protein
  • AD1 protein
  • Adap protein
  • Ag protein
  • app protein
  • APP-like protein
  • APPI protein
  • appl protein
  • BcDNA:GH04413 protein
  • betaApp protein
  • CG7727 protein
  • CTFgamma protein
  • Cvap protein
  • Dmel\\CG7727 protein
  • E030013M08Rik protein
  • EG:65F1.5 protein
  • PN-II protein
  • PN2 protein
  • wu:fj34d10 protein
  • wu:fk65e12 protein
  • zgc:85740 protein

Protein level used designations for APP

Appl-PA , Appl-PB , Appl-PC , Appl-PD , Appl-PE , Appl-PF , CG7727-PA , CG7727-PB , CG7727-PC , CG7727-PD , CG7727-PE , CG7727-PF , amyloid precursor protein , amyloid precursor protein-like , beta-amyloid-protein-precursor-like , amyloid beta (A4) precursor protein , amyloid beta A4 protein , amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) , amyloid beta (A4) precursor protein (peptidase nexin-2, Alzheimer disease) , amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) , beta-amyloid precursor protein , alzheimer disease amyloid protein , beta-amyloid peptide , cerebral vascular amyloid peptide , peptidase nexin-II , preA4 , protease nexin-II , amyloid protein , ABPP , alzheimer disease amyloid A4 protein homolog , amyloidogenic glycoprotein , appican , protease nexin II , AG , amyloid A4 , beta-amyloid precursor protein A , Amyloid beta A4 protein precursor (APP) (ABPP) (Alzheimers disease amyloid protein) (Cerebral vascular amyloid peptide) (CVAP) (Protease nexin-II) (PN-II) (APPI) (PreA4) , amyloid beta precursor protein a

31002 Drosophila melanogaster
708212 Macaca mulatta
448208 Xenopus (Silurana) tropicalis
351 Homo sapiens
374198 Gallus gallus
397663 Sus scrofa
280722 Bos taurus
11820 Mus musculus
54226 Rattus norvegicus
403407 Canis lupus familiaris
398223 Xenopus laevis
100715302 Cavia porcellus
101111593 Ovis aries
100427716 Macaca mulatta
473931 Pan troglodytes
58083 Danio rerio
100009546 Oryctolagus cuniculus
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