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Browse our Cofilin 2 Proteins (CFL2)

Full name:
Cofilin 2 (Muscle) Proteins (CFL2)
On are 14 Cofilin 2 (Muscle) (CFL2) Proteins from 8 different suppliers available. Additionally we are shipping Cofilin 2 Antibodies (75) and Cofilin 2 Kits (32) and many more products for this protein. A total of 126 Cofilin 2 products are currently listed.
cf12, CFL2, NEM7, wu:fb17d06, wu:fb18d11, wu:fd59f08, wu:fj34b08, xac1, xac2, zgc:77288
list all proteins Gene Name GeneID UniProt
CFL2 1073 Q9Y281
CFL2 12632 P45591
Rat CFL2 CFL2 366624  

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Cofilin 2 Proteins (CFL2) by Origin

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Top referenced Cofilin 2 Proteins

  1. Human Cofilin 2 Protein expressed in Escherichia coli (E. coli) - ABIN667534 : Agrawal, Greenleaf, Tomczak, Lehtokari, Wallgren-Pettersson, Wallefeld, Laing, Darras, Maciver, Dormitzer, Beggs: Nemaline myopathy with minicores caused by mutation of the CFL2 gene encoding the skeletal muscle actin-binding protein, cofilin-2. in American journal of human genetics 2006 (PubMed)
    Show all 2 references for ABIN667534

More Proteins for Cofilin 2 Interaction Partners

Xenopus laevis Cofilin 2 (Muscle) (CFL2) interaction partners

  1. Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.

Human Cofilin 2 (Muscle) (CFL2) interaction partners

  1. analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover

  2. In primary tumours, both desmin (show DES Proteins) and CFL2 expression predicted improved overall survival in multivariate analyses

  3. Cofilin 2 phosphorylation and genetic overexpression plays a role in the pathogenesis of idiopathic dilated cardiomyopthay.

  4. patients with severe nemaline myopathy should be screened for mutations in CFL2.

  5. study investigated the comparison of the levels of cofilin-1 (show CFL1 Proteins) and cofilin-2 in regressive QR-32 and progressive QRsP-11cells by western blotting

  6. Studies indicate that cofilin binds actin stoichiometrically - one cofilin molecule per actin filament subunit.

  7. A novel homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met) of CFL2 was identified in two siblings with congenital myopathy.

  8. cofilins 1 and 2 only weakly interact with 14-3-3 (show YWHAQ Proteins) and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 (show HSPB6 Proteins) for its binding to 14-3-3 zeta (show YWHAZ Proteins)

  9. the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state

  10. Differential expression of up-regulated cofilin-1 (show CFL1 Proteins) and down-regulated cofilin-2 characteristic of pancreatic cancer tissues

Pig (Porcine) Cofilin 2 (Muscle) (CFL2) interaction partners

  1. Examined the expression of MyHC 2x, MyHC 2b (show MYH4 Proteins) and MyHC1/slow in C2C12 cells expressing CFL2b. Results showed the level of MyHC 2x and MyHC 2b (show MYH4 Proteins) mRNA were dramatically increased compared with control cells, while the level of MyHC1/slow mRNA is not changed.

Mouse (Murine) Cofilin 2 (Muscle) (CFL2) interaction partners

  1. deficiency of cofilin-2 is associated with interruption of the cell cycle at several checkpoints, hindering muscle regeneration

  2. Levels of smooth muscle alpha-actin (show ACTA2 Proteins) were increased and remained high in developing muscles, suggesting that cofilin2 plays a crucial role during the exchange of alpha-actin (show ACTA2 Proteins) isoforms during the early postnatal remodeling of the sarcomere.

  3. cofilin-2, although not critical for muscle development, is essential for muscle maintenance.

  4. role of Cofilin-2 in actin dynamics

  5. MLP (show MARCKSL1 Proteins) binds directly to CFL2 in human cardiac and skeletal muscles.

Cofilin 2 (CFL2) Protein Profile

Protein Summary

This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Cofilin 2 (CFL2)

  • cofilin 2, like (cfl2l)
  • cofilin 1 (non-muscle) (cfl1-b)
  • cofilin 2 (muscle) (cfl2)
  • cofilin 2 (muscle) (CFL2)
  • cofilin 2 (non-muscle) (cfl2)
  • cofilin 2 (cf12)
  • cofilin 2 (muscle) (Cfl2)
  • cofilin 2, muscle (Cfl2)
  • cf12 protein
  • CFL2 protein
  • NEM7 protein
  • wu:fb17d06 protein
  • wu:fb18d11 protein
  • wu:fd59f08 protein
  • wu:fj34b08 protein
  • xac1 protein
  • xac2 protein
  • zgc:77288 protein

Protein level used designations for Cofilin 2 (Muscle) Proteins (CFL2)

muscle cofilin 2 , ADF/cofilin-2 , cofilin 2 , cofilin-1-B , cofilin-2 , cofilin 2 (muscle) , cofilin, muscle isoform , nemaline myopathy type 7

321496 Danio rerio
379172 Xenopus laevis
403001 Danio rerio
452853 Pan troglodytes
496574 Xenopus (Silurana) tropicalis
100194616 Salmo salar
423320 Gallus gallus
1073 Homo sapiens
490649 Canis lupus familiaris
497233 Sus scrofa
100727405 Cavia porcellus
539332 Bos taurus
101118388 Ovis aries
12632 Mus musculus
366624 Rattus norvegicus
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