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Results suggest that elevation of actin dynamics by Xenopus ADF/cofilin (XAC) activation through Slingshot phosphatase (XSSH) phosphorylation is required for meiotic spindle assembly.
The greatest levels of circulating miR (show MLXIP Proteins)-297 and miR (show MLXIP Proteins)-19b-3p with its common target CFL2 are associated with metastatic prostate cancer.
analysis of human Cof1, Cof2, and ADF effects on actin filament severing and turnover
In primary tumours, both desmin (show DES Proteins) and CFL2 expression predicted improved overall survival in multivariate analyses
Cofilin 2 phosphorylation and genetic overexpression plays a role in the pathogenesis of idiopathic dilated cardiomyopthay.
patients with severe nemaline myopathy should be screened for mutations in CFL2.
study investigated the comparison of the levels of cofilin-1 (show CFL1 Proteins) and cofilin-2 in regressive QR-32 and progressive QRsP-11cells by western blotting
Studies indicate that cofilin binds actin stoichiometrically - one cofilin molecule per actin filament subunit.
A novel homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met) of CFL2 was identified in two siblings with congenital myopathy.
cofilins 1 and 2 only weakly interact with 14-3-3 (show YWHAQ Proteins) and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 (show HSPB6 Proteins) for its binding to 14-3-3 zeta (show YWHAZ Proteins)
the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state
Examined the expression of MyHC 2x, MyHC 2b (show MYH4 Proteins) and MyHC1/slow in C2C12 cells expressing CFL2b. Results showed the level of MyHC 2x and MyHC 2b (show MYH4 Proteins) mRNA were dramatically increased compared with control cells, while the level of MyHC1/slow mRNA is not changed.
miR (show MLXIP Proteins)-301a regulates Cofilin-2 in vitro in NRVCM, and in vivo in Cs1-ko mice. Our findings provide an additional and important layer of Cfl2 regulation, which we believe has an extended role in cardiac signal transduction and dilated cardiomyopathy presumably due to the reported involvement of Cfl2 in these mechanisms.
Vessel wall P2Y12 (show P2RY12 Proteins) receptor, which promotes VSMCs migration through cofilin (show CFL1 Proteins) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.
deficiency of cofilin-2 is associated with interruption of the cell cycle at several checkpoints, hindering muscle regeneration
Levels of smooth muscle alpha-actin (show ACTA2 Proteins) were increased and remained high in developing muscles, suggesting that cofilin2 plays a crucial role during the exchange of alpha-actin (show ACTA2 Proteins) isoforms during the early postnatal remodeling of the sarcomere.
cofilin-2, although not critical for muscle development, is essential for muscle maintenance.
role of Cofilin-2 in actin dynamics
MLP (show MARCKSL1 Proteins) binds directly to CFL2 in human cardiac and skeletal muscles.
This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.
muscle cofilin 2
, cofilin 2
, cofilin 2 (muscle)
, cofilin, muscle isoform
, nemaline myopathy type 7