Browse our Gelsolin Proteins (GSN)

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Gelsolin Proteins (GSN)
On are 19 Gelsolin (GSN) Proteins from 7 different suppliers available. Additionally we are shipping Gelsolin Antibodies (212) and Gelsolin Kits (62) and many more products for this protein. A total of 304 Gelsolin products are currently listed.
ADF, AGEL, cb499, CG1106, DGS, Dmel\\CG1106, fb94b12, fc04g09, gel, gsn, gsnl1, sb:cb499, scin, wu:fc04g09
list all proteins Gene Name GeneID UniProt
GSN 2934 P06396
GSN 227753 P13020
GSN 296654 Q68FP1

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Gelsolin Proteins (GSN) by Origin

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More Proteins for Gelsolin Interaction Partners

Human Gelsolin (GSN) interaction partners

  1. free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.

  2. analysis of how YopO disrupts normal gelsolin function to alter host actin dynamics and thus cripple phagocytosis

  3. Our present study implied that the synergistic effect of pGSN and pIgA (show PIGA Proteins) induced glomerular fibrosis via the TGF-beta1 (show TGFB1 Proteins)/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients.

  4. The expression levels of GSN were observed to be reduced in colon carcinoma (CC) cells, and the reduced expression level of GSN was often associated with a poorer metastasisfree survival rate in patients with CC (P=0.04). In addition, the overexpression of GSN inhibited the invasion of CC cells in vitro.

  5. in chronic hemodialysis patients, lower pGSN levels were not associated with hospitalization, all-cause and cardio-vascular mortality, even though pGSN was inversely correlated with age, CRP (show CRP Proteins) and IL-6 (show IL6 Proteins), suggesting that inflammation may influence pGSN

  6. PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.

  7. These findings suggest that gelsolin may have a role in the disease process in atopic dermatitis patients.

  8. Plasma GSN may play an important role in the development of immunoglobulin A (IgA) nephropathy.

  9. beta-Catenin (show CTNNB1 Proteins) seems to be involved in the regulation of gelsolin expression, which in turn affects the migratory ability of colonic cancer cells

  10. hypoxia or GSN overexpression induces HIF-1alpha (show HIF1A Proteins) expression and reduces the expression of survival markers p-Akt (show AKT1 Proteins) and Bcl-2 (show BCL2 Proteins) in H9c2 cardiomyoblast cells

Pig (Porcine) Gelsolin (GSN) interaction partners

  1. model of the N-terminal extension on the surface of the gelsolin molecule, which was unknown previously

  2. the observed structural transitions contribute to the stable binding of the second actin monomer in the ternary gelsolin-actin complex

Mouse (Murine) Gelsolin (GSN) interaction partners

  1. free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.

  2. gelsolin plays a critical role in airway smooth muscle relaxation.

  3. We conclude that a nanobody-based gene therapy using adeno (show ADORA2A Proteins)-associated viruses shows great potential as a novel strategy in gelsolin amyloidosis and potentially other amyloid diseases.

  4. The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Proteins) and actin mediated via gelsolin, suggesting that CCT (show FLVCR2 Proteins) may influence processes depending on gelsolin activity, such as cell motility.

  5. novel roles for actin-depolymerizing factor (show DSTN Proteins) and cofilin-1 (show CFL1 Proteins) in regulating the remodeling and permeability of epithelial junctions

  6. The data of this study identify overlapping functions for ADF (show TXN Proteins) and n-cofilin (show CFL1 Proteins) in presynaptic physiology and vesicle in mice. trafficking.

  7. Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes

  8. Clic1 (show CLIC1 Proteins) have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (show ANXA7 Proteins) and Gelsolin.

  9. our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3 (show ATF3 Proteins)-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex

  10. Plasma gelsolin levels decrease in the blood of mice with type II diabetes.

Horse (Equine) Gelsolin (GSN) interaction partners

  1. Ca2 (show CA2 Proteins)+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

Zebrafish Gelsolin (GSN) interaction partners

  1. Data show that scinla and scinlb have different expression patterns and developmental roles during zebrafish development.

  2. Data suggest that scinla and scinlb are diverged paralogs of the vertebrate scinderin (show SCIN Proteins) gene, and show that scinla encodes the zebrafish corneal crystallin previously called C/L-gelsolin.

Gelsolin (GSN) Protein Profile

Protein Summary

The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.

Alternative names and synonyms associated with Gelsolin (GSN)

  • gelsolin (GSN)
  • Gelsolin (Gel)
  • gelsolin (gsn)
  • gelsolin (Gsn)
  • scinderin like a (scinla)
  • ADF protein
  • AGEL protein
  • cb499 protein
  • CG1106 protein
  • DGS protein
  • Dmel\\CG1106 protein
  • fb94b12 protein
  • fc04g09 protein
  • gel protein
  • gsn protein
  • gsnl1 protein
  • sb:cb499 protein
  • scin protein
  • wu:fc04g09 protein

Protein level used designations for Gelsolin Proteins (GSN)

gelsolin (amyloidosis, Finnish type) , CG1106-PA , CG1106-PB , CG1106-PD , CG1106-PF , CG1106-PJ , CG1106-PK , CG1106-PL , Gel-PA , Gel-PB , Gel-PD , Gel-PF , Gel-PJ , Gel-PK , Gel-PL , drosophila gelsolin , gelsolin , scinderin , actin-depolymerizing factor , brevin , ADF , homogenin , C/L gelsolin , gelsolin, like 1

464706 Pan troglodytes
100172865 Pongo abelii
46008 Drosophila melanogaster
549610 Xenopus (Silurana) tropicalis
100579247 Nomascus leucogenys
2934 Homo sapiens
396874 Sus scrofa
535077 Bos taurus
227753 Mus musculus
100337841 Oryctolagus cuniculus
296654 Rattus norvegicus
474819 Canis lupus familiaris
395774 Gallus gallus
699705 Macaca mulatta
397895 Xenopus laevis
100722590 Cavia porcellus
100034186 Equus caballus
323285 Danio rerio
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