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study strongly supported the contribution of the genes ITGA2B, GSN and RHOA and the two pathways "regulation of actin cytoskeleton" and "leukocyte transendothelial migration" to osteoporosis risk.
SSH1 (show SSH1 Proteins) binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 (show SSH1 Proteins) in cell-free assays and in cultured cells.
free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria.
analysis of how YopO disrupts normal gelsolin function to alter host actin dynamics and thus cripple phagocytosis
Our present study implied that the synergistic effect of pGSN and pIgA (show PIGA Proteins) induced glomerular fibrosis via the TGF-beta1 (show TGFB1 Proteins)/Smads signal transduction pathway. This might be a potential mechanism for the glomerular fibrosis observed in IgAN patients.
The expression levels of GSN were observed to be reduced in colon carcinoma (CC) cells, and the reduced expression level of GSN was often associated with a poorer metastasisfree survival rate in patients with CC (P=0.04). In addition, the overexpression of GSN inhibited the invasion of CC cells in vitro.
in chronic hemodialysis patients, lower pGSN levels were not associated with hospitalization, all-cause and cardio-vascular mortality, even though pGSN was inversely correlated with age, CRP (show CRP Proteins) and IL-6 (show IL6 Proteins), suggesting that inflammation may influence pGSN
PODXL enhances motility and invasiveness through an increase in gelsolin-actin interactions in cell protrusions.
These findings suggest that gelsolin may have a role in the disease process in atopic dermatitis patients.
Plasma GSN may play an important role in the development of immunoglobulin A (IgA) nephropathy.
model of the N-terminal extension on the surface of the gelsolin molecule, which was unknown previously
the observed structural transitions contribute to the stable binding of the second actin monomer in the ternary gelsolin-actin complex
gelsolin plays a critical role in airway smooth muscle relaxation.
We conclude that a nanobody-based gene therapy using adeno (show ADORA2A Proteins)-associated viruses shows great potential as a novel strategy in gelsolin amyloidosis and potentially other amyloid diseases.
The data presented here reveal an additional level of interplay between CCT (show FLVCR2 Proteins) and actin mediated via gelsolin, suggesting that CCT (show FLVCR2 Proteins) may influence processes depending on gelsolin activity, such as cell motility.
novel roles for actin-depolymerizing factor (show DSTN Proteins) and cofilin-1 (show CFL1 Proteins) in regulating the remodeling and permeability of epithelial junctions
The data of this study identify overlapping functions for ADF (show TXN Proteins) and n-cofilin (show CFL1 Proteins) in presynaptic physiology and vesicle in mice. trafficking.
Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes
Clic1 (show CLIC1 Proteins) have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 (show ANXA7 Proteins) and Gelsolin.
our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3 (show ATF3 Proteins)-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex
Plasma gelsolin levels decrease in the blood of mice with type II diabetes.
Ca2 (show CA2 Proteins)+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin
Data show that scinla and scinlb have different expression patterns and developmental roles during zebrafish development.
Data suggest that scinla and scinlb are diverged paralogs of the vertebrate scinderin (show SCIN Proteins) gene, and show that scinla encodes the zebrafish corneal crystallin previously called C/L-gelsolin.
The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene.
gelsolin (amyloidosis, Finnish type)
, drosophila gelsolin
, actin-depolymerizing factor
, C/L gelsolin
, gelsolin, like 1