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anti-Human MADD Antibodies:
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Human Polyclonal MADD Primary Antibody for IHC (fro), WB - ABIN2475471
Schievella, Chen, Graham, Lin: MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase. in The Journal of biological chemistry 1997
Show all 2 Pubmed References
The risk of coronary disease and ischemic stroke associated with multiple polymorphisms and haplotypes of MADD and FOLH1 in Han Chinese patients are reported in association with alcohol consumption.
miR (show MLXIP Antibodies)-3151 silencing by DNA methylation (show HELLS Antibodies) protected chronic lymphocytic leukemia cells from apoptosis by over-expression of its direct targets MADD (show ETFA Antibodies) and PIK3R2, constitutive activation of MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling , and over-expression of MCL1 (show MCL1 Antibodies).
Taken together, our data reveal that PTEN (show PTEN Antibodies) can convey the death signal by preventing MADD (show ETFA Antibodies) phosphorylation by Akt (show AKT1 Antibodies).
These results suggest that MADD (show ETFA Antibodies) may be a potential therapeutic target for lung adenocarcinoma therapy involving the TRAIL-induced apoptosis pathway
MADD (show ETFA Antibodies) knockdown resulted in enhanced spontaneous apoptosis in human breast cancer cell lines
We analyzed DENN/MADD/IG20 (DMI), the complex of four splice variants in Alzheimer's disease.
SNP rs2290149, located in a genetic cluster of MYBPC3 (show MYBPC3 Antibodies) and MADD (show ETFA Antibodies) gene, was found to be associated with diastolic heart failure.
Data show that ehe expression of MAPK (show MAPK1 Antibodies)-activating death domain protein (MADD (show ETFA Antibodies)) increases obviously in lung adenocarcinoma, and MADD (show ETFA Antibodies) can promote survival of lung adenocarcinoma cells by inhibiting apoptosis.
The SNP in ADCY5 (show ADCY5 Antibodies) is implicated in defective proinsulin (show INS Antibodies)-to-insulin (show INS Antibodies) conversion and previous findings on the role of a genetic variant in MADD (show ETFA Antibodies) on proinsulin (show INS Antibodies)-to-insulin (show INS Antibodies) conversion, were confirmed.
Data show that SNPs from MADD (show ETFA Antibodies), PROX1 (show PROX1 Antibodies), and SLC30A8 (show SLC30A8 Antibodies) were associated with type 2 diabetes.
These findings indicated that IG20/MADD plays a critical role in glucose-induced insulin (show INS Antibodies) release from beta-cells and that its functional disruption can cause type 2 diabetes.
role of Rab3 GEP in regulating neurotransmitter release in autapses of mouse hippocampal neurons in culture
DENN has anti-apoptotic and cell survival roles in tumor cells
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene.
MAP-kinase activating death domain
, MAP kinase-activating death domain protein
, MAP kinase-activating death domain protein-like
, Rab3 GDP/GTP exchange factor
, differentially expressed in normal and neoplastic cells
, insulinoma glucagonoma clone 20
, Rab3 GDP/GTP exchange protein
, Rab3 GEP
, insulinoma-glucagonoma protein 20
, rab3 GDP/GTP exchange factor