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B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.
In a model of human epilepsy, topo I shows a novel function in construction and/or maintenance of circuits required for seizure propagation in vivo.
In the floral meristem, the binding of AG to WUS is reduced in top1a-2, which results in reduced H3K27me3 levels at WUS and prolonged WUS expression, and consequently loss of floral determinacy.
Further studies with Arabidopsis top1alpha mutants showed that TOP1alpha silences endogenous RdDM loci by facilitating the production of Pol V-dependent long non-coding RNAs, AGONAUTE4 recruitment and H3K9me2 deposition at TEs (show TES Proteins) and repeats
MGO1 encodes a putative Arabidopsis type IB topoisomerase that functions together with WUS in stem cell regulation. [MGO1]
While TOP-1alpha isoform has tissue specificity, the TOP-1beta isoform is expressed in most tissues and cells. RNAi targeted to both TOP-1 isoforms demonstrated that TOP-1 is required for chromosomal segregation, germline proliferation and gonadal migration.
HMGA2 potentiates the clinically important topoisomerase I inhibitor irinotecan/SN-38 in trapping the enzyme in covalent DNA-complexes, thereby attenuating transcription.
IMMP2L (show IMMP2L Proteins) transcription requires Topoisomerase I in human primary astrocytes
This work identifies ADP-ribose polymers as key determinant for regulating Top1 subnuclear dynamics.
High prevalence of anti-topoisomerase I antibody positivity was found among Thai systemic sclerosis patients and this was associated with a high frequency of hand deformity, ACA negativity, a short duration of pulmonary fibrosis in diffuse cutaneous and a lower frequency of Raynaud's phenomenon in limited cutaneous subsets.
These findings reveal BAZ1B (show BAZ1B Proteins) as a key facilitator of topoisomerase I function during DNA replication that affects the response of cancer cells to topoisomerase I inhibitors.
Results identified TOP1 gene copy gain, a loss of chromosome 20, and new yet unreported TOP1 mutations (R364K and G717R) in close proximity to the SN-38 binding site conferring colon cancer cells resistance to the drug.
the highest expression of GGH (show GGH Proteins) and EGFR (show EGFR Proteins) was noted in the left-sided colon; the highest expression of DHFR (show DHFR Proteins), FPGS (show FPGS Proteins), TOP1 and ERCC1 (show ERCC1 Proteins) was noted in the rectosigmoid, whereas TYMP (show TYMP Proteins) expression was approximately equivalent in the right-sided colon and rectum
We found that the resistant cell lines showed 7-100 fold increased resistance to SN-38 but remained sensitive to docetaxel and the non-camptothecin Top1 inhibitor LMP400
Data show that the single-molecule supercoil relaxation assay is a sensitive method to elucidate the detailed mechanisms of type IB topoisomerase (Top1) inhibitors and is relevant for the cellular efficacy of Top1 inhibitors.
TOP1 bound at promoters was discovered to become fully active only after pause-release. This transition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNAPII) with stimulation of TOP1 above its basal rate, enhancing its processivity.
this study identified topoisomerase 1 as a cardinal (show CARD8 Proteins) Aire (show AIRE Proteins) partner that colocalized on super-enhancers and was required for the interaction of Aire (show AIRE Proteins) with all of its other associates
Data indicate that mitochondrial topoisomerase I (TOP1mt (show TOP1MT Proteins)) knockout (KO) mice showed a marked reduction in regeneration and hepatocyte proliferation.
Topoisomerase I deficiency in B cells is associated with RNA polymerase II accumulation, recruitment of activation-induced deaminase (show AICDA Proteins) (AID) to immunoglobulin variable genes and the mechanism for increased diversity of these genes.
Findings suggest that topoisomerase 1 (TOP1) controls the levels of multiple synaptic proteins and is required for normal excitatory and inhibitory synaptic transmission.
Top1mt (show TOP1MT Proteins) accumulates in the regulatory region of mitochondrial DNA.
our data implicate Top1mt (show TOP1MT Proteins) for mitochondrial integrity and energy metabolism.
model in which small molecule inhibitors convert PARP1 (show PARP1 Proteins) into a protein that potentiates the effects of topoisomerase I poisons by binding to damaged DNA and preventing its normal repair.
AID-induced Top1 reduction alters S region DNA structure probably to non-B form, on which Top1 can introduce nicks but cannot religate, resulting in S region cleavage.
The contributions of strong and week nonspecific electrostatic, van (show SLC11A2 Proteins) der (show GDF3 Proteins) Waals's, and hydrophobic interactions, and hydrogen bonding of the enzymes to the complex formation with the single- and double-stranded DNAs were determined.
Several alternatively spliced genes, characterized by small exons and large introns, are down-regulated in Topo I-deficient p388 leukemia cells.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.
, topoisomerase 1
, topoisomerase I
, type I topoisomerase
, DNA topoisomerase I
, DNA topoisomerase 1
, type I DNA topoisomerase