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Browse our Topoisomerase I Proteins (TOP1)

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Topoisomerase (DNA) I Proteins (TOP1)
On are 12 Topoisomerase (DNA) I (TOP1) Proteins from 9 different suppliers available. Additionally we are shipping Topoisomerase I Antibodies (60) and Topoisomerase I Kits (14) and many more products for this protein. A total of 89 Topoisomerase I products are currently listed.
Ab2-086, AI467334, CG6146, D130064I21Rik, Dmel\\CG6146, DNA topoisomerase 1 beta, DNA topoisomerase I alpha, dTopoI, l(1)G0134, l(1)G0201, l(1)G0229, l(1)G0278, l(1)top1, MGO1, MGOUN 1, MTE17.1, MTE17_1, Top-1, top1, TOP1BETA, topi, topo I, topoI, TOPOISOMERASE 1
list all proteins Gene Name GeneID UniProt
TOP1 7150 P11387
TOP1 21969 Q04750
TOP1 64550 Q9WUL0

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Topoisomerase I Proteins (TOP1) by Origin

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More Proteins for Topoisomerase I Interaction Partners

Fruit Fly (Drosophila melanogaster) Topoisomerase (DNA) I (TOP1) interaction partners

  1. B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.

  2. In a model of human epilepsy, topo I shows a novel function in construction and/or maintenance of circuits required for seizure propagation in vivo.

Arabidopsis thaliana Topoisomerase (DNA) I (TOP1) interaction partners

  1. In the floral meristem, the binding of AG to WUS is reduced in top1a-2, which results in reduced H3K27me3 levels at WUS and prolonged WUS expression, and consequently loss of floral determinacy.

  2. Further studies with Arabidopsis top1alpha mutants showed that TOP1alpha silences endogenous RdDM loci by facilitating the production of Pol V-dependent long non-coding RNAs, AGONAUTE4 recruitment and H3K9me2 deposition at TEs (show TES Proteins) and repeats

  3. MGO1 encodes a putative Arabidopsis type IB topoisomerase that functions together with WUS in stem cell regulation. [MGO1]

Caenorhabditis elegans (C. elegans) Topoisomerase (DNA) I (TOP1) interaction partners

  1. While TOP-1alpha isoform has tissue specificity, the TOP-1beta isoform is expressed in most tissues and cells. RNAi targeted to both TOP-1 isoforms demonstrated that TOP-1 is required for chromosomal segregation, germline proliferation and gonadal migration.

Human Topoisomerase (DNA) I (TOP1) interaction partners

  1. We found that the resistant cell lines showed 7-100 fold increased resistance to SN-38 but remained sensitive to docetaxel and the non-camptothecin Top1 inhibitor LMP400

  2. Data show that the single-molecule supercoil relaxation assay is a sensitive method to elucidate the detailed mechanisms of type IB topoisomerase (Top1) inhibitors and is relevant for the cellular efficacy of Top1 inhibitors.

  3. TOP1 bound at promoters was discovered to become fully active only after pause-release. This transition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNAPII) with stimulation of TOP1 above its basal rate, enhancing its processivity.

  4. Data show that inhibition of DNA-dependent protein kinase catalytic subunit (show PRKDC Proteins) (DNA-PK) prevents type I DNA topoisomerase (Top1) degradation and proteasome activity in camptothecin (CPT (show CHPT1 Proteins))-treated quiescent WI38 cells.

  5. NO-induced down-regulation of topoisomerase I protein.

  6. b-ELE could inhibit the proliferation of HepG-2 cells and interfere with the expression and activity of TOPO I and TOPO IIa

  7. Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers.

  8. Cinobufacini inhibited the proliferation of the HepG-2 cells induced apoptosis in a dose- and time-dependent manner and downregulated the mRNA and protein expression levels of TOPO I and TOPO II (show TOP2 Proteins)

  9. YB-1 (show YBX1 Proteins) serves as an intracellular promoter of TOPO1 catalytic activity that enhances camptothecin sensitivity through its direct interaction with TOPO1.

  10. We here report that a substantial number of patients with bile duct or pancreatic cancer have increased TOP1 copy number and increased TOP1/centromere-20 ratio.

Mouse (Murine) Topoisomerase (DNA) I (TOP1) interaction partners

  1. Data indicate that mitochondrial topoisomerase I (TOP1mt (show TOP1MT Proteins)) knockout (KO) mice showed a marked reduction in regeneration and hepatocyte proliferation.

  2. Topoisomerase I deficiency in B cells is associated with RNA polymerase II accumulation, recruitment of activation-induced deaminase (show AICDA Proteins) (AID) to immunoglobulin variable genes and the mechanism for increased diversity of these genes.

  3. Findings suggest that topoisomerase 1 (TOP1) controls the levels of multiple synaptic proteins and is required for normal excitatory and inhibitory synaptic transmission.

  4. Top1mt (show TOP1MT Proteins) accumulates in the regulatory region of mitochondrial DNA.

  5. our data implicate Top1mt (show TOP1MT Proteins) for mitochondrial integrity and energy metabolism.

  6. model in which small molecule inhibitors convert PARP1 (show PARP1 Proteins) into a protein that potentiates the effects of topoisomerase I poisons by binding to damaged DNA and preventing its normal repair.

  7. AID-induced Top1 reduction alters S region DNA structure probably to non-B form, on which Top1 can introduce nicks but cannot religate, resulting in S region cleavage.

  8. The contributions of strong and week nonspecific electrostatic, van (show SLC11A2 Proteins) der (show GDF3 Proteins) Waals's, and hydrophobic interactions, and hydrogen bonding of the enzymes to the complex formation with the single- and double-stranded DNAs were determined.

  9. Several alternatively spliced genes, characterized by small exons and large introns, are down-regulated in Topo I-deficient p388 leukemia cells.

  10. topoisomerase I-mediated DNA damage and cell death is induced by hydrogen peroxide

Topoisomerase I (TOP1) Protein Profile

Protein Summary

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

Alternative names and synonyms associated with Topoisomerase I (TOP1)

  • Topoisomerase 1 (Top1)
  • DNA topoisomerase I (top1)
  • DNA topoisomerase I (topA)
  • DNA topoisomerase I (ZMO1193)
  • DNA topoisomerase I (Mrad2831_6322)
  • DNA topoisomerase I (Lferr_0016)
  • DNA topoisomerase I (PC1_2015)
  • DNA topoisomerase I (Za10_0136)
  • DNA topoisomerase I (Gbro_0575)
  • DNA topoisomerase I (Dd586_2108)
  • DNA topoisomerase I (Kvar_3044)
  • DNA topoisomerase I (Alvin_2069)
  • DNA topoisomerase I (Dacet_0849)
  • DNA topoisomerase I (Mrub_1615)
  • DNA topoisomerase I (Arnit_2962)
  • DNA topoisomerase I (Ndas_4953)
  • DNA topoisomerase I (Trad_2377)
  • DNA topoisomerase I (Acear_1653)
  • DNA topoisomerase I (Mahau_0844)
  • DNA topoisomerase I (Mesop_4109)
  • DNA topoisomerase I (Thein_1586)
  • DNA topoisomerase I (Theth_0241)
  • DNA topoisomerase 1 (TOP1ALPHA)
  • Protein TOP-1 (top-1)
  • topoisomerase (DNA) I (TOP1)
  • topoisomerase (DNA) I (Top1)
  • topoisomerase (DNA) I, gene 1 (top1.1)
  • Ab2-086 protein
  • AI467334 protein
  • CG6146 protein
  • D130064I21Rik protein
  • Dmel\\CG6146 protein
  • DNA topoisomerase 1 beta protein
  • DNA topoisomerase I alpha protein
  • dTopoI protein
  • l(1)G0134 protein
  • l(1)G0201 protein
  • l(1)G0229 protein
  • l(1)G0278 protein
  • l(1)top1 protein
  • MGO1 protein
  • MGOUN 1 protein
  • MTE17.1 protein
  • MTE17_1 protein
  • Top-1 protein
  • top1 protein
  • TOP1BETA protein
  • topi protein
  • topo I protein
  • topoI protein
  • TOPOISOMERASE 1 protein

Protein level used designations for Topoisomerase (DNA) I Proteins (TOP1)

CG6146-PA , CG6146-PB , CG6146-PC , CG6146-PD , Top1-PA , Top1-PB , Top1-PC , Top1-PD , topoisomerase 1 , topoisomerase I , topoisomerase1 , type I topoisomerase , DNA topoisomerase I , DNA topoisomerase 1 , type I DNA topoisomerase

32458 Drosophila melanogaster
2540032 Schizosaccharomyces pombe 972h-
2649678 Corynebacterium diphtheriae NCTC 13129
3189286 Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
6141892 Methylobacterium radiotolerans JCM 2831
6875965 Acidithiobacillus ferrooxidans ATCC 53993
8132959 Pectobacterium carotovorum subsp. carotovorum PC1
8471215 Zymomonas mobilis subsp. mobilis NCIMB 11163
8549909 Gordonia bronchialis DSM 43247
8661047 Dickeya dadantii Ech586
8783203 Klebsiella variicola At-22
8787439 Allochromatium vinosum DSM 180
8875197 Denitrovibrio acetiphilus DSM 12809
8879720 Meiothermus ruber DSM 1279
9173158 Arcobacter nitrofigilis DSM 7299
9248841 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9281380 Truepera radiovictrix DSM 17093
9513710 Acetohalobium arabaticum DSM 5501
10607584 Mahella australiensis 50-1 BON
10827957 Mesorhizobium opportunistum WSM2075
10841850 Thermodesulfatator indicus DSM 15286
10884985 Thermotoga thermarum DSM 5069
835623 Arabidopsis thaliana
266847 Caenorhabditis elegans
7150 Homo sapiens
21969 Mus musculus
64550 Rattus norvegicus
399263 Xenopus laevis
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