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anti-Mouse (Murine) Cadherin 4 Antibodies:
anti-Rat (Rattus) Cadherin 4 Antibodies:
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Mouse (Murine) Monoclonal Cadherin 4 Primary Antibody for IP, IHC - ABIN967954
Hutton, Christofori, Chi, Edman, Guest, Hanahan, Kelly: Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue. in Molecular endocrinology (Baltimore, Md.) 1994
Show all 3 Pubmed References
Human Polyclonal Cadherin 4 Primary Antibody for WB - ABIN4286919
Mills, Globa, Liu, Cowan, Mobasser, Phillips, Borgland, Bamji: Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning. in Nature neuroscience 2017
cadherin 2 (CDH2 (show CDH2 Antibodies)) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B (show PTPN1 Antibodies)) and alpha- and beta-catenins.
Pioneer axon outgrowth was rescued in vivo by selective replacement of R-cadherin by electroporation into cultured Pax6 (show PAX6 Antibodies) mutant embryos
analysis of subpopulations of HSCs for expression of cell surface adhesion molecules found that R-cadherin was preferentially expressed by HSCs functionally targeting neovascularization in the developing retina
Killer cell lectin-like receptor (show Klra6 Antibodies) G1 (KLRG1 (show KLRG1 Antibodies)) ligation by R-cadherin may regulate the cytotoxicity of killer cells to prevent damage to tissues expressing cadherins.
suggest that R-cad is an adhesion molecule (show NCAM1 Antibodies) of the mammary epithelium, which acts as a critical regulator of the normal phenotype
Both Cdh2 (show CDH2 Antibodies) and Cdh4 immunoreactivities were specifically up-regulated in regenerating retina and/or the optic pathway and both may be important for regeneration of injured retinal ganglion cell axons
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1 (show CDH1 Antibodies), -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
Cadherin-4 was not detected in the embryonic Zebrafish cerebellum, but it was expressed in the Purkinje cells of the larval and adult cerebellum.
Cdh4 is necessary for neural retina survival and differentiation
Results indicate that Cdh4 plays a role in the normal formation of the zebrafish lateral line system and a subset of the cranial ganglia.
Low expression of CDH4 is associated with lung cancer.
Further knockdown R-cadherin in linc-cdh4-2 stably overexpressed cells, could significantly upregulate the protein levels of RAC1 and improve the cell migration and invasion abilities. Taken together, the novel linc-cdh4-2 may negatively regulate the motility of the HCC cells through targeting R-cadherin-RAC1 signaling pathway.
Data show that low expression of R-cadherin is associated with the poor prognosis in gastric cancer.
P-cadherin expression correlated with tumor progression and could be an independent predictor for bladder cancer survival.
R-cadherin adherens junction formation facilitates a mesenchymal to epithelial-like transition in MDA-MB-231 cells.
Findings identify an important role of CHD4 (show CHD4 Antibodies) in controlling homologous recombination repair to maintain genome stability and establish the potential therapeutic implications of targeting CHD4 (show CHD4 Antibodies) deficiency in tumors.
a novel putative tumor suppressor gene that can be frequently and tumor-specifically inactivated by its promoter methylation in nasopharyngeal carcinoma
R-cadherin induces cell motility when expressed in epithelial cells, and this increased motility is dependent upon Rho GTPase (show RACGAP1 Antibodies) activity.
CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis
the degradation of E-cadherin (show CDH1 Antibodies) in response to expression of R-cadherin is due to competition for p120(ctn (show CTNND1 Antibodies))
The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior-posterior neuroblast migration.
CDH-4 functions to ensure that proper cell contacts are made and maintained during development.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene.
cadherin 4, type 1, R-cadherin (retinal)
, retina cadherin
, retinal cadherin
, cadherin 4 type 1 R-cadherin (retinal)
, cadherin 4, type 1, preproprotein