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Browse our CNTNAP1 Proteins (CNTNAP1)

Full name:
Contactin Associated Protein 1 Proteins (CNTNAP1)
On are 8 Contactin Associated Protein 1 (CNTNAP1) Proteins from 4 different suppliers available. Additionally we are shipping CNTNAP1 Antibodies (41) and CNTNAP1 Kits (17) and many more products for this protein. A total of 68 CNTNAP1 products are currently listed.
AI841080, Caspr, CNTNAP, CNTNAP1, NCP1, Nrxn4, p190, shm
list all proteins Gene Name GeneID UniProt
CNTNAP1 8506 P78357
Rat CNTNAP1 CNTNAP1 84008 P97846
CNTNAP1 53321 O54991

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CNTNAP1 Proteins (CNTNAP1) by Origin

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More Proteins for CNTNAP1 Interaction Partners

Human Contactin Associated Protein 1 (CNTNAP1) interaction partners

  1. CNTNAP1 mutations were found to induce characteristic ultrastructural lesions of the paranodal region.

  2. report a consanguineous Arab family from Qatar with three children having an early lethal form of arthrogryposis multiplex congenita and a novel frameshift mutation in CNTNAP1

  3. Mutations in CNTNAP1 and ADCY6 (show ADCY6 Proteins) are responsible for severe arthrogryposis multiplex congenita with axoglial defects

  4. VDAC1 (show VDAC1 Proteins) and CNTNAP1 associate with gamma-secretase in detergent-resistant membranes and affect amyloid precursor protein (show APP Proteins) processing.

Mouse (Murine) Contactin Associated Protein 1 (CNTNAP1) interaction partners

  1. Simultaneous deletion of Caspr and Caspr2 (show CNTNAP2 Proteins) disrupts the internodal organization of Kv1.2 (show KCNA2 Proteins).

  2. Caspr co-localizes and interacts with APP (show APP Proteins). Amyloid-beta (Abeta (show APP Proteins)) 40 and Abeta42 generation were also reduced in HEK (show EPHA3 Proteins)-APP (show APP Proteins) cells by Caspr overexpression.

  3. Caspr labeling was observed through much of the retina, including horizontal, bipolar, amacrine, and ganglion cells.

  4. Clustering of Caspr at initial contact sites between OL processes and the axon requires glial expression of NF155 but not of contactin. Expression of membrane proteins along the axolemma is determined by the type of the contacting glial cells.

  5. These results suggest that Caspr serves as a "transmembrane scaffold" that stabilizes the Caspr/contactin adhesion complex at the paranodal junction by connecting it to cytoskeletal components within the axon.

  6. F3/contactin and caspr/paranodin traffic to the cell surface via a non-conventional pathway

  7. Nogo-A (show RTN4 Proteins) interacts in trans with axonal Caspr at CNS paranodes, an interaction that may have a role in modulating axon-glial junction architecture and possibly K(+)-channel (show KCNC4 Proteins) localization during development.

  8. the Caspr/Cont complex is essential for the formation of axoglial SJ

  9. Caspr protein is required for recruitment and retention of KCNQ4 (show KCNQ4 Proteins) at calyceal synapses in vestibular hair cells.

  10. The Caspr gene has been identified in the neurological mutant shambling (shm) mouse and shown to encode the contactin-associated protein, which is a major component of the paranodal junction in myelinated nerves.

CNTNAP1 Protein Profile

Protein Summary

The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons.

Alternative names and synonyms associated with CNTNAP1

  • contactin associated protein 1 (CNTNAP1)
  • contactin associated protein 1 (cntnap1)
  • contactin associated protein 1 (Cntnap1)
  • contactin associated protein 1 (LOC100351604)
  • contactin associated protein-like 1 (Cntnap1)
  • AI841080 protein
  • Caspr protein
  • CNTNAP protein
  • CNTNAP1 protein
  • NCP1 protein
  • Nrxn4 protein
  • p190 protein
  • shm protein

Protein level used designations for CNTNAP1

contactin associated protein 1 , contactin-associated protein 1-like , caspr1 , contactin-associated protein 1 , neurexin 4 , neurexin IV , neurexin-4 , p190 , paranodin , MHDNIV , neurexin 4 (contactin associated protein)

454696 Pan troglodytes
100037844 Xenopus (Silurana) tropicalis
100390860 Callithrix jacchus
100450795 Pongo abelii
100481010 Ailuropoda melanoleuca
100559472 Anolis carolinensis
100604186 Nomascus leucogenys
8506 Homo sapiens
84008 Rattus norvegicus
100351604 Oryctolagus cuniculus
100719034 Cavia porcellus
100521039 Sus scrofa
490960 Canis lupus familiaris
540997 Bos taurus
428309 Gallus gallus
101111565 Ovis aries
53321 Mus musculus
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