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Browse our F11R Proteins (F11R)

Full name:
F11 Receptor Proteins (F11R)
On are 24 F11 Receptor (F11R) Proteins from 9 different suppliers available. Additionally we are shipping F11R Antibodies (161) and F11R Kits (22) and many more products for this protein. A total of 230 F11R products are currently listed.
9130004G24, AA638916, CD321, ESTM33, JAM, JAM-1, JAM-A, Jam1, JAMA, Jcam, Jcam1, KAT, Ly106, PAM-1
list all proteins Gene Name GeneID UniProt
F11R 50848 Q9Y624
F11R 16456 O88792
F11R 116479 Q9JHY1

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F11R Proteins (F11R) by Origin

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Top referenced F11R Proteins

  1. Human F11R Protein expressed in Human Cells - ABIN2002316 : Sobocka, Sobocki, Banerjee, Weiss, Rushbrook, Norin, Hartwig, Salifu, Markell, Babinska, Ehrlich, Kornecki: Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. in Blood 2000 (PubMed)
    Show all 6 references for ABIN2002316

  2. Rat (Rattus) F11R Protein expressed in Human Cells - ABIN2009357 : Williams, Martin-Padura, Dejana, Hogg, Simmons: Identification and characterisation of human Junctional Adhesion Molecule (JAM). in Molecular immunology 2000 (PubMed)
    Show all 6 references for ABIN2009357

  3. Mouse (Murine) F11R Protein expressed in Human Cells - ABIN2007830 : Babinska, Kedees, Athar, Ahmed, Batuman, Ehrlich, Hussain, Kornecki: F11-receptor (F11R/JAM) mediates platelet adhesion to endothelial cells: role in inflammatory thrombosis. in Thrombosis and haemostasis 2002 (PubMed)
    Show all 6 references for ABIN2007830

  4. Human F11R Protein expressed in Escherichia coli (E. coli) - ABIN1098287 : Murakami, Giampietro, Giannotta, Corada, Torselli, Orsenigo, Cocito, dArio, Mazzarol, Confalonieri, Di Fiore, Dejana: Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression. in PLoS ONE 2011 (PubMed)

More Proteins for F11R Interaction Partners

Human F11 Receptor (F11R) interaction partners

  1. Our results showed that APOC3 (show APOC3 Proteins) was closely associated with the inflammatory process in ECs, and that this process was characterized by the increased expression of TNF-alpha (show TNF Proteins). Inflammatory processes further disrupted the tight junctions (TJs) between HUVECs by causing increased expression of JAM-1.

  2. High expression of junctional adhesion molecule-A and EphB2 (show EPHB2 Proteins) can predict poor overall survival and high mortality rate, and EphB2 (show EPHB2 Proteins) is an independent prognostic biomarker in lung adenocarcinoma patients.

  3. JAM-A is one of the malignancy markers of HNSCC as well as beta-catenin (show CTNNB1 Proteins) in histopathology, and the plasma-soluble JAM-A may contribute to a serum diagnosis of HNSCC. JAM-A is a promising molecular target for diagnosis and therapy in HNSCC.

  4. F11R mrna expression was higher in rheumatoid arthritis patients, but promoter polymorphisms did not appear to be related to disease susceptibility.

  5. Data indicate that junctional adhesion molecule-A (JAM-A) is overexpressed in multiple myeloma (MM) cells and regulates reovirus sensitivity in MM.

  6. JAM-A regulates the planar orientation of the mitotic spindle during epithelial morphogenesis. It triggers transient activation of Cdc42 and PI3K, generates a gradient of PtdIns(3,4,5)P3 at the cortex and regulates the formation of the actin cytoskeleton.

  7. Data indicate that junctional adhesion molecule A (JAM-A) is a potential target of microRNA-495 {miR (show MLXIP Proteins)-495) in breast cancer cells.

  8. RNA interference mediated JAM-A gene silencing promotes human epidermal stem cell proliferation.

  9. JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects

  10. JAM-A promotes proliferation and inhibits apoptosis of gastric cancer, suggesting that it has a pivotal role in gastric cancer progression.

Mouse (Murine) F11 Receptor (F11R) interaction partners

  1. Soluble JAM-A secreted from cardiac progenitor cells reduces infiltration of neutrophils after myocardial infarction and ameliorates tissue damage through prevention of excess inflammation.

  2. JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects

  3. Endothelial JAM-A but not hematopoietic JAM-A facilitates reovirus T1L (show CERS6 Proteins) bloodstream entry and egress.

  4. Deletion of JAM-A causes a gain-of-function in platelets, with lower activation thresholds and increased inflammatory activities. This leads to an increase of plaque formation, particularly in early stages of the disease.

  5. The F11r gene is directly regulated by retinoic acid in the embryonic mesoderm.

  6. Redistribution of JAM-A in endothelial cells after stimulation with pro-atherogenic oxidized lipoproteins results in increased transmigration of mononuclear cells.

  7. JAM-A has a prominent role in regulating leukocyte infiltration after brain I/R injury and could be a new target in limiting post-ischemic inflammation.

  8. JAM-A regulates epithelial permeability via association with ZO-2 (show TJP2 Proteins), afadin, and PDZ-GEF1 (show RAPGEF2 Proteins) to activate Rap2c (show RAP2C Proteins) and control contraction of the apical cytoskeleton.

  9. Cancer stem cells selectively express JAM-A, which regulates self-renewal.

  10. These studies establish F11R as a novel monocyte prognostic marker for GBM critical for defining a subpopulation of stromal cells for future potential therapeutic intervention.

F11R Protein Profile

Protein Summary

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.

Alternative names and synonyms associated with F11R

  • F11 receptor (F11R)
  • F11 receptor (F11r)
  • 9130004G24 protein
  • AA638916 protein
  • CD321 protein
  • ESTM33 protein
  • JAM protein
  • JAM-1 protein
  • JAM-A protein
  • Jam1 protein
  • JAMA protein
  • Jcam protein
  • Jcam1 protein
  • KAT protein
  • Ly106 protein
  • PAM-1 protein

Protein level used designations for F11 Receptor Proteins (F11R)

junctional adhesion molecule 1 , junctional adhesion molecule A , platelet F11 receptor , platelet adhesion molecule 1 , BV11 antigen , F11 receptor/F11R , junction cell adhesion molecule A , junction cell adhesion molecule1 , JAM-1 , JAM-A

50848 Homo sapiens
16456 Mus musculus
116479 Rattus norvegicus
281258 Bos taurus
653015 Felis catus
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