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These data highlight the importance of the carboxy-terminal motif of the E6 protein and downregulation of PAR3 in tumorigenic transformation of human cervical keratinocytes.
Results suggest that Par3 expression is likely involved in ovarian cancer progression, especially in peritoneal metastasis, probably through modulating IL-6 (show IL6 Proteins) /STAT3 (show STAT3 Proteins) signaling.
reduced keratinocytes Par3 function fosters a permissive P-cadherin-dependent niche for melanocytes transformation, invasion, and metastasis.
These results demonstrate the importance of Par3 and SNAIL (show SNAI1 Proteins) in development of KSHV-induced B-cells cancers
PAR-3 protein expression is frequently lost in primary esophageal squamous cell carcinoma and loss of the PAR-3 protein is associated with aggressive clinicopathological features.
Taken together, these results suggest that the Par3 regulates invasion and metastasis in pancreatic cancers by controlling tight junction assembly via Tiam1 (show TIAM1 Proteins).
PAR3 is essential in thrombin (show F2 Proteins) stimulated insulin (show INS Proteins) secretion.
Knockdown of the polarity protein Par3 reversed the effects of Galpha13 (show GNA13 Proteins) knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen.
Par-3 plays an important role in the modulation of intestinal barrier function by regulating delivery of occludin as well as suppression of MLC phosphorylation.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (show NOS3 Proteins)-Thr (show TRH Proteins)-495 with minimal phosphorylation of eNOS (show NOS3 Proteins)-Ser (show SIGLEC1 Proteins)-1177 with no change in nitric oxide production.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (show IQGAP2 Proteins)) and F2rl2
Simultaneous depletion of PAR-1 (show MARK2 Proteins) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (show KLK1 Proteins) -signaling axis in neurons that is mediated by PAR1 (show F2R Proteins) and PAR2 (show F2RL1 Proteins) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (show F3 Proteins)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (show F2R Proteins)-type thrombin (show F2 Proteins) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (show F2RL3 Proteins) by the active site of thrombin (show F2 Proteins).
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
, protease-activated receptor 3
, proteinase-activated receptor 3
, proteinase-activated receptor-3
, thrombin receptor-like 2
, Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
, coagulation factor II receptor-like 2
, coagulation factor II (thrombin) receptor-like 2 L homeolog