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anti-Human BMI1 Antibodies:
anti-Mouse (Murine) BMI1 Antibodies:
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Human Monoclonal BMI1 Primary Antibody for BI, IHC (f) - ABIN2688857
Dimri, Martinez, Jacobs, Keblusek, Itahana, Van Lohuizen, Campisi, Wazer, Band: The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. in Cancer research 2002
Show all 6 Pubmed References
Human Monoclonal BMI1 Primary Antibody for ICC, FACS - ABIN968985
Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. in Cancer research 2009
Show all 2 Pubmed References
Human Monoclonal BMI1 Primary Antibody for ChIP - ABIN2668619
Lafkas, Rodilla, Huyghe, Mourao, Kiaris, Fre: Notch3 marks clonogenic mammary luminal progenitor cells in vivo. in The Journal of cell biology 2013
Show all 2 Pubmed References
Human Polyclonal BMI1 Primary Antibody for ICC, IF - ABIN152245
Kang, Qi, Zuo, Wang, Zou, Schwartz, Cheng, Yeh: SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. in Molecular cell 2010
Human Polyclonal BMI1 Primary Antibody for ICC, IF - ABIN257760
Ismail, Andrin, McDonald, Hendzel: BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. in The Journal of cell biology 2010
Human Monoclonal BMI1 Primary Antibody for ELISA, WB - ABIN560071
Andrews, Banting, Damjanov, Arnaud, Avner: Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. in Hybridoma 1985
Show all 2 Pubmed References
Human Monoclonal BMI1 Primary Antibody for ICC, IF - ABIN2668620
Bracken, Kleine-Kohlbrecher, Dietrich, Pasini, Gargiulo, Beekman, Theilgaard-Mönch, Minucci, Porse, Marine, Hansen, Helin: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. in Genes & development 2007
Human Monoclonal BMI1 Primary Antibody for WB - ABIN2477676
Sánchez, Sánchez, Demmers, Rodriguez, Strouboulis, Vidal: Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. in Molecular & cellular proteomics : MCP 2007
Human Polyclonal BMI1 Primary Antibody for IHC (fro), WB - ABIN2477677
Mandal, Boitano, Maxwell, Lou, Alexander: Ninety-eight penetrating vascular injuries: a review of a two and one-half year experience. in The Journal of trauma 1976
Show all 3 Pubmed References
Human Monoclonal BMI1 Primary Antibody for CyTOF, FACS - ABIN4900505
Shen, Chen, Ding, Qi, Cen, Wang, Yao, Chen: BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression. in Journal of cellular and molecular medicine 2014
Bmi1 acts immediately downstream of CCAAT enhancer binding protein-alpha (show CEBPA Antibodies) to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
We found that BMI1 showed increased expression in hypoxic-cultured hUCB-MSCs, and the further knock-down of BMI1 in hypoxic cells induced decreased proliferative and immunomodulatory abilities in hUCB-MSCs, along with COX-2 (show COX2 Antibodies)/PGE2 down-regulation. More importantly, we identified BMI1 as a direct repressor of MAP kinase phosphatase-1 (MKP-1 (show DUSP1 Antibodies))/DUSP1 (show DUSP1 Antibodies), which suppresses p38 MAP kinase (show MAPK14 Antibodies) activity.
Collectively, the data establish a hitherto unknown liaison among MDR1 (show TBC1D9 Antibodies), BMI1 and TIP60 (show KAT5 Antibodies) and provide mechanistic insights into cisplatin-induced MDR1 (show TBC1D9 Antibodies) expression resulting in acquired cross-resistance against paclitaxel, doxorubicin and likely other anticancer drugs.
Thus, VEGFA (show VEGFA Antibodies) stimulates ovarian cancer stem-like cells through Src (show SRC Antibodies)-DNMT3A (show DNMT3A Antibodies)-driven miR (show MLXIP Antibodies)-128-2 methylation and Bmi1 upregulation.
Loss of BMI1 enhanced ribonuclease activity of polynucleotide phosphorylase and reduced mtRNA stability
These findings uncover a previously unrecognized role for MUC1 (show MUC1 Antibodies)-C in driving BMI1 expression and in directly interacting with this stem cell factor (show KITLG Antibodies), linking MUC1 (show MUC1 Antibodies)-C with function of the PRC1 (show PRC1 Antibodies) in epigenetic gene silencing.
Results show that the expression of BMI1 is elevated in human HBV-related hepatocellular carcinoma tissues.
BMI1 is a downstream target of GSK3 (show GSK3b Antibodies) signaling.
According to our data, significant elevation of the expression of miR (show MLXIP Antibodies)-218 and downregulation of BMI1 were observed in clinical breast cancer specimens compared with normal tissues ( p < 0.0001).
MCM4 (show MCM4 Antibodies) and MCM7 (show MCM7 Antibodies) expression is significantly correlated with Ki-67 (show MKI67 Antibodies), Bmi1, and cyclin E (show CCNE1 Antibodies) expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions.
newly identified miR (show MLXIP Antibodies)-376c/BMI1 pathway provides an insight into cervical cancer progression
KLF4 (show KLF4 Antibodies) modulates development of BMI1-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (show GUSB Antibodies) injury in mice.
The retinal phenotype of Bmi1(-/-) mice was characterized by loss of heterochromatin, activation of tandem repeats, oxidative stress and Rip3 (show MPRIP Antibodies)-associated necroptosis.
Inducible fate mapping demonstrates that BMI1 is expressed in vivo by multipotent Olfactory epithelium progenitors. expression of BMI1 and other Polycomb (show CBX2 Antibodies) proteins not previously identified in olfactory basal cells are essential for self-renewal.
We conclude that silencing of Bmi1 by miR (show MLXIP Antibodies)-27b relieves repression of the presynaptic transcriptome and supports neurotransmission in cortical networks.
a full complement of Bmi-1 is required for the intestinal proliferative effects of GLP-2 in both the physiological and pathological setting
Our work revealed that MOZ (show MYST3 Antibodies) and BMI1 regulate HSCs in a synergistic manner by acting on distinct processes required to maintain HSCs.
Bmi-1 played a critical role in the protection from acute tubular necrosis by maintaining mobilization of renal stem cells and would be a novel therapeutic target for preventing the progression of ATN
Bmi1 deletion could substitute for Gata4 (show GATA4 Antibodies) during iCM reprogramming. Thus, Bmi1 acts as a critical epigenetic barrier to iCM production. Bypassing this barrier simplifies iCM generation and increases yield, potentially streamlining iCM production for therapeutic purposes.
Cardiac Bmi1 progenitor cells respond to cardiac injury, contributing to the generation of de novo cardiomyocytes in the adult mouse heart.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
B lymphoma Mo-MLV insertion region 1 homolog
, murine leukemia viral (bmi-1) oncogene homolog
, polycomb complex protein BMI-1
, polycomb group RING finger protein 4
, polycomb group protein Bmi1
, ring finger protein 51
, BMI1 polycomb ring finger oncogene
, B lymphoma Mo-MLV insertion region 1
, polycomb group ring finger 4
, polycomb complex protein BMI-1-A
, polycomb group RING finger protein 4-A
, B lymphoma Mo-MLV insertion region
, Polycomb group RING finger protein 4-B
, polycomb complex protein BMI-1-B
, polycomb group RING finger protein 4-B
, oncoprotein BMI-1