Browse our anti-BRCA1 (BRCA1) Antibodies

Full name:
anti-Breast Cancer 1 Antibodies (BRCA1)
On www.antibodies-online.com are 569 Breast Cancer 1 (BRCA1) Antibodies from 34 different suppliers available. Additionally we are shipping BRCA1 Kits (30) and BRCA1 Proteins (10) and many more products for this protein. A total of 624 BRCA1 products are currently listed.
Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
list all antibodies Gene Name GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

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Most Popular Reactivities for anti-BRCA1 (BRCA1) Antibodies

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anti-Mouse (Murine) BRCA1 Antibodies:

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anti-Rat (Rattus) BRCA1 Antibodies:

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Top referenced anti-BRCA1 Antibodies

  1. Human Monoclonal BRCA1 Primary Antibody for IHC (p), IP - ABIN445490 : Bernard-Gallon, Déchelotte, Vissac, Aunoble, Cravello, Malpuech, Bignon: BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. in Breast cancer research : BCR 2001 (PubMed)
    Show all 8 references for 445490

  2. Human Monoclonal BRCA1 Primary Antibody for ICC, FACS - ABIN152032 : Okada, Ouchi: Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. in The Journal of biological chemistry 2003 (PubMed)
    Show all 4 references for 152032

  3. Human Monoclonal BRCA1 Primary Antibody for CyTOF, FACS - ABIN152030 : Yin, Wei, Li, Cao, Guo: Identification and molecular characterization of a new member of the peritrophic membrane proteins from the meadow moth, loxostege sticticalis. in International journal of biological sciences 2010 (PubMed)
    Show all 4 references for 152030

  4. Human Polyclonal BRCA1 Primary Antibody for IHC, ELISA - ABIN1532821 : Miki, Swensen, Shattuck-Eidens, Futreal, Harshman, Tavtigian, Liu, Cochran, Bennett, Ding: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 2 references for 1532821

  5. Human Polyclonal BRCA1 Primary Antibody for ELISA, WB - ABIN1532128 : Wilson, Payton, Elliott, Buaas, Cajulis, Grosshans, Ramos, Reese, Slamon, Calzone: Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. in Oncogene 1997 (PubMed)
    Show all 2 references for 1532128

  6. Human Monoclonal BRCA1 Primary Antibody for IHC, ELISA - ABIN1724848 : Muñoz, Laulier, Gunn, Cheng, Robbiani, Nussenzweig, Stark: RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. in The Journal of biological chemistry 2012 (PubMed)

  7. Cow (Bovine) Polyclonal BRCA1 Primary Antibody for IHC, WB - ABIN2777874 : Evans, Shenton, Woodward, Lalloo, Howell, Maher: Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family. in BMC cancer 2008 (PubMed)

  8. Human Polyclonal BRCA1 Primary Antibody for IP, WB - ABIN318902 : Venkitaraman: Functions of BRCA1 and BRCA2 in the biological response to DNA damage. in Journal of cell science 2001 (PubMed)

More Antibodies against BRCA1 Interaction Partners

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB (show NFKB1 Antibodies) signaling.

  2. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  3. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 (show CDKN2A Antibodies) and a decline of stem cell function, which was rescued by p16 (show CDKN2A Antibodies) loss.

  4. Brca1-Wwox (show WWOX Antibodies) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (show WWOX Antibodies)-sufficient cells

  5. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  6. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  7. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (show COBRA1 Antibodies)-dependent transcription program during mammary gland development.

  8. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  9. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  10. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Antibodies) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

Human Breast Cancer 1 (BRCA1) interaction partners

  1. A breakdown in a BRCA/FANCD2 (show FANCD2 Antibodies)/BRG1 (show SMARCA4 Antibodies)/SNF (show SNRPA Antibodies)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.

  2. Neoadjuvant chemotherapy for BRCA1-associated ovarian carcinoma is accompanied by a rapid expansion of pre-existing BRCA1-proficient tumor clones suggesting that continuation of the same therapy after NACT and surgery may not be justified.

  3. Being a male BRCA1 or a BRCA2 (show BRCA2 Antibodies) mutation carrier or even being clinically defined as having high cancer risk with no known BRCA mutation in men is not associated with any clinically significant risk for developing this rare entity.

  4. Data from our systematic review and meta-analysis suggests a causal relationship between germline BRCA1/2-pathogenic mutations and the development of Uterine serous carcinoma.

  5. study demonstrates that the individual and combined expression patterns of the DDR (show DDR1 Antibodies) molecules PARP1 (show PARP1 Antibodies), gammaH2AX (show H2AFX Antibodies), BRCA1, and BRCA2 (show BRCA2 Antibodies) could be predictive of the prognosis of STS (show STS Antibodies) patients and suggests that controlling the activity of these DDR (show DDR1 Antibodies) molecules could be employed in new therapeutic stratagems for the treatment of STS (show STS Antibodies)

  6. We show that BRCA1 mutations are associated with a radiosensitive phenotype related to a compromised DNA repair and G2 arrest capacity after exposure to either 2 or 4 Gy.

  7. Cdk-dependent phosphorylation of TRF1 on threonine 371 promotes TRF1 to interact with APBs in S and G2 phases independently of its binding to telomeric DNA. We have demonstrated that the interaction of (pT371)TRF1 with APBs is dependent upon ATM and homologous-recombination-promoting factors such as Mre11 and BRCA1.

  8. Data suggest that RAD51 (show RAD51 Antibodies), BRCA2 (show BRCA2 Antibodies), and BRCA1 promote stability of nascent DNA at replication forks; RAD51 (show RAD51 Antibodies) prevents MRE11 (show MRE11A Antibodies) nuclease (show DCLRE1C Antibodies)-mediated degradation of nascent ssDNA; BRCA2 (show BRCA2 Antibodies) displaces RPA (show RPA1 Antibodies) (replication protein A (show GPR153 Antibodies)) complex by recruiting RAD51 (show RAD51 Antibodies) to protect ssDNA; BRCA1 promotes repair foci following DNA damage and is essential for cell survival. (BRCA = breast cancer recombination protein; RAD51 (show RAD51 Antibodies) = Rad51 (show RAD51 Antibodies) recombinase (show RAG1 Antibodies)) [REVIEW]

  9. misfolding mutations impair the nuclear targeting of BRCA1 in yeast cells and in a human cell line. In

  10. our results provided evidence that cancer cells employ a strategy to remove deleterious germline BRCA1 mutations through alternative mRNA splicing, giving rise to isoforms that retain residual activity and contribute to therapeutic resistance

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Antigen Profile

Antigen Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1) antibody
  • breast cancer 1, early onset (BRCA1) antibody
  • breast cancer 1, early onset (Brca1) antibody
  • BRCAI antibody
  • BRCC1 antibody
  • BROVCA1 antibody
  • IRIS antibody
  • PNCA4 antibody
  • PPP1R53 antibody
  • PSCP antibody
  • RNF53 antibody

Protein level used designations for anti-Breast Cancer 1 (BRCA1) Antibodies

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

GENE ID SPECIES
12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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