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Browse our anti-BRCA1 (BRCA1) Antibodies

Full name:
anti-Breast Cancer 1 Antibodies (BRCA1)
On www.antibodies-online.com are 575 Breast Cancer 1 (BRCA1) Antibodies from 33 different suppliers available. Additionally we are shipping BRCA1 Kits (29) and BRCA1 Proteins (10) and many more products for this protein. A total of 629 BRCA1 products are currently listed.
Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
list all antibodies Gene Name GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

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Most Popular Reactivities for anti-BRCA1 (BRCA1) Antibodies

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anti-Mouse (Murine) BRCA1 Antibodies:

anti-Human BRCA1 Antibodies:

anti-Rat (Rattus) BRCA1 Antibodies:

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Top referenced anti-BRCA1 Antibodies

  1. Human Monoclonal BRCA1 Primary Antibody for IHC (p), IP - ABIN445490 : Bernard-Gallon, Déchelotte, Vissac, Aunoble, Cravello, Malpuech, Bignon: BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. in Breast cancer research : BCR 2001 (PubMed)
    Show all 8 references for ABIN445490

  2. Human Monoclonal BRCA1 Primary Antibody for CyTOF, FACS - ABIN152030 : Okada, Ouchi: Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. in The Journal of biological chemistry 2003 (PubMed)
    Show all 4 references for ABIN152030

  3. Human Monoclonal BRCA1 Primary Antibody for ICC, FACS - ABIN152032 : Martin, Nahas, Tunuguntla, Fike, Gatti: Assessing 'radiosensitivity' with kinetic profiles of γ-H2AX, 53BP1 and BRCA1 foci. in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2011 (PubMed)
    Show all 4 references for ABIN152032

  4. Human Monoclonal BRCA1 Primary Antibody for ChIP, ICC - ABIN151868 : Li, Ting, Zheng, Chen, Ziv, Shiloh, Lee, Lee: Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. in Nature 2000 (PubMed)
    Show all 3 references for ABIN151868

  5. Human Polyclonal BRCA1 Primary Antibody for IHC, ELISA - ABIN1532821 : Miki, Swensen, Shattuck-Eidens, Futreal, Harshman, Tavtigian, Liu, Cochran, Bennett, Ding: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 2 references for ABIN1532821

  6. Human Polyclonal BRCA1 Primary Antibody for ELISA, WB - ABIN1532128 : Wilson, Payton, Elliott, Buaas, Cajulis, Grosshans, Ramos, Reese, Slamon, Calzone: Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b. in Oncogene 1997 (PubMed)
    Show all 2 references for ABIN1532128

  7. Human Polyclonal BRCA1 Primary Antibody for IP, WB - ABIN318902 : Venkitaraman: Functions of BRCA1 and BRCA2 in the biological response to DNA damage. in Journal of cell science 2001 (PubMed)

  8. Human Polyclonal BRCA1 Primary Antibody for IHC, WB - ABIN2777874 : Evans, Shenton, Woodward, Lalloo, Howell, Maher: Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast/ovarian cancer quoted should reflect the cancer burden in the family. in BMC cancer 2008 (PubMed)

  9. Human Monoclonal BRCA1 Primary Antibody for IHC, ELISA - ABIN1724848 : Muñoz, Laulier, Gunn, Cheng, Robbiani, Nussenzweig, Stark: RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. in The Journal of biological chemistry 2012 (PubMed)

More Antibodies against BRCA1 Interaction Partners

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 (show CDKN2A Antibodies) and a decline of stem cell function, which was rescued by p16 (show CDKN2A Antibodies) loss.

  2. Brca1-Wwox (show WWOX Antibodies) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (show WWOX Antibodies)-sufficient cells

  3. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  4. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  5. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (show COBRA1 Antibodies)-dependent transcription program during mammary gland development.

  6. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  7. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  8. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Antibodies) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

  9. Data show that mammary tumors resembling BRCA1-associated metaplastic breast carcinoma display intrinsic resistance to the poly(ADP-ribose) polymerase (PARP (show PARP1 Antibodies)) inhibitor olaparib as a result of increased P-glycoprotein drug efflux transporter expression.

  10. Downregulation of BRCA1 protein levels was a result of endoplasmic reticulum stress.

Human Breast Cancer 1 (BRCA1) interaction partners

  1. Approximately 73% of hereditary triple-negative breast cancers were BRCA1/2-associated and 27% were BRCA1/2-negative. The expression levels of the analyzed genes showed no significant differences between these two subgroups indicating the BRCAness of the BRCA1/2-negative hereditary TNBCs

  2. Data suggest that, similar to Caucasians, a significant proportion of Asian ovarian cancer was attributed to germline mutations in BRCA1 and to a lesser extent in BRCA2 (show BRCA2 Antibodies).

  3. We found an approximately approximately 3 fold increased rate of high RS among BRCA1 and 2 carriers with ER positive breast cancer (BC)compared with the general BC population

  4. results suggests that BRCA1 mutation carriers with breast cancer are more likely to have P53 (show TP53 Antibodies) overexpression compared with BRCA2 (show BRCA2 Antibodies) mutation carriers and non-carriers (Meta-analysis).

  5. We recommend BRCA1/2 genetic testing to all Chinese women diagnosed with EOC to identify HBOC families, to provide genetic counseling and clinical management for at-risk relatives. Mutation carriers may also benefit from PARP (show COL11A2 Antibodies)-targeted therapies.

  6. Combined SSO and PARP inhibitor treatment increased gammaH2AX expression indicating that SSO-dependent skipping of BRCA1 exon 11 was able to promote double strand DNA breaks and therefore synthetic lethality in breast tumor cell lines

  7. BRCA1 mutation is associated with breast cancer.

  8. immunohistochemical BRCA1 expression in epithelial ovarian cancer holds considerable prognostic information, whereas PARP (show COL11A2 Antibodies) expression did not influence the outcome

  9. Common variation in BRCA1 may influence clinical outcomes in patients receiving RT for localized prostate cancer by modifying the response to RT.

  10. Brca1-Wwox (show WWOX Antibodies) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (show WWOX Antibodies)-sufficient cells

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Antigen Profile

Antigen Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1) antibody
  • breast cancer 1, early onset (BRCA1) antibody
  • breast cancer 1, early onset (Brca1) antibody
  • BRCAI antibody
  • BRCC1 antibody
  • BROVCA1 antibody
  • IRIS antibody
  • PNCA4 antibody
  • PPP1R53 antibody
  • PSCP antibody
  • RNF53 antibody

Protein level used designations for anti-Breast Cancer 1 (BRCA1) Antibodies

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

GENE ID SPECIES
12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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