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Browse our BRCA1 (BRCA1) ELISA Kits

Full name:
Breast Cancer 1 ELISA Kits (BRCA1)
On www.antibodies-online.com are 29 Breast Cancer 1 (BRCA1) ELISA Kits from 9 different suppliers available. Additionally we are shipping BRCA1 Antibodies (563) and BRCA1 Proteins (10) and many more products for this protein. A total of 617 BRCA1 products are currently listed.
Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
list all ELISA KIts Gene Name GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

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More ELISA Kits for BRCA1 Interaction Partners

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 and a decline of stem cell function, which was rescued by p16 loss.

  2. Brca1-Wwox (show WWOX ELISA Kits) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (show WWOX ELISA Kits)-sufficient cells

  3. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  4. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  5. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (show COBRA1 ELISA Kits)-dependent transcription program during mammary gland development.

  6. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  7. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  8. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 ELISA Kits) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

  9. Data show that mammary tumors resembling BRCA1-associated metaplastic breast carcinoma display intrinsic resistance to the poly(ADP-ribose) polymerase (PARP (show PARP1 ELISA Kits)) inhibitor olaparib as a result of increased P-glycoprotein drug efflux transporter expression.

  10. Downregulation of BRCA1 protein levels was a result of endoplasmic reticulum stress.

Human Breast Cancer 1 (BRCA1) interaction partners

  1. From a mechanistic standpoint, hsa-miR-125a-3p directly targeted 3'-untranslated regions (3'-UTRs) of breast cancer early onset gene 1 (BRCA1) and inhibits its protein expression via translational repression mechanism.

  2. Data show that there are large differences in the absolute cancer risks between breast cancer 1, early onset protein (BRCA1) and breast cancer 2, early onset protein (BRCA2) mutation carriers with higher vs lower values of the polygenic risk scores (PRS).

  3. Studies indicate almost 20% of women with high-grade serous ovarian cancer are now recognized to harbour a germ line BRCA mutation, and of these, >40% might not have a family history of cancer and would not have received BRCA1 and BRCA2 (show BRCA2 ELISA Kits) testing.

  4. BRCA1 mutation is associated with pancreatic cancer.

  5. The Single-molecule molecular inversion probes (smMIP)-based genetic testing enables automated and reliable analysis of the coding sequences of BRCA1.

  6. A heterozygous deletion of exon 19 of BRCA1 and the other was a heterozygous duplication of exon 4-6 of BRCA1 were identified in large genomic rearrangements.

  7. BRCA1 and BRCA2 (show BRCA2 ELISA Kits) pathogenic mutations and their prediction have been characterized in the Italian breast and ovarian cancer pedigrees using two genetic models.

  8. uptake of risk-reducing salpingo-oophorectomy among BRCA1/2 mutation carriers who were counseled at our Family Cancer Clinic is extremely high

  9. Approximately 73% of hereditary triple-negative breast cancers were BRCA1/2-associated and 27% were BRCA1/2-negative. The expression levels of the analyzed genes showed no significant differences between these two subgroups indicating the BRCAness of the BRCA1/2-negative hereditary TNBCs

  10. Data suggest that, similar to Caucasians, a significant proportion of Asian ovarian cancer was attributed to germline mutations in BRCA1 and to a lesser extent in BRCA2 (show BRCA2 ELISA Kits).

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Antigen Profile

Antigen Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1) Elisa Kit
  • breast cancer 1, early onset (BRCA1) Elisa Kit
  • breast cancer 1, early onset (Brca1) Elisa Kit
  • BRCAI Elisa Kit
  • BRCC1 Elisa Kit
  • BROVCA1 Elisa Kit
  • IRIS Elisa Kit
  • PNCA4 Elisa Kit
  • PPP1R53 Elisa Kit
  • PSCP Elisa Kit
  • RNF53 Elisa Kit

Protein level used designations for Breast Cancer 1 (BRCA1) ELISA Kits

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

GENE ID SPECIES
12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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