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Browse our BRCA1 Proteins (BRCA1)

Full name:
Breast Cancer 1 Proteins (BRCA1)
On www.antibodies-online.com are 10 Breast Cancer 1 (BRCA1) Proteins from 6 different suppliers available. Additionally we are shipping BRCA1 Antibodies (492) and BRCA1 Kits (29) and many more products for this protein. A total of 546 BRCA1 products are currently listed.
Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
list all proteins Gene Name GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

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BRCA1 Proteins (BRCA1) by Origin

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More Proteins for BRCA1 Interaction Partners

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  2. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  3. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (show COBRA1 Proteins)-dependent transcription program during mammary gland development.

  4. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  5. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  6. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Proteins) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

  7. Data show that mammary tumors resembling BRCA1-associated metaplastic breast carcinoma display intrinsic resistance to the poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) inhibitor olaparib as a result of increased P-glycoprotein drug efflux transporter expression.

  8. Downregulation of BRCA1 protein levels was a result of endoplasmic reticulum stress.

  9. BRCA1 regulated cell cycle checkpoints in a manner dependent on the 26S proteasome (show Psmd4 Proteins) activity.

  10. work therefore ascribes novel roles for BRCA1 and CtIP (show RBBP8 Proteins) in end-processing and fusion reactions at uncapped telomeres

Human Breast Cancer 1 (BRCA1) interaction partners

  1. Women with a germline mutation in BRCA1 have reduced ovarian reserve as measured by Anti-Mullerian hormone (show AMH Proteins).

  2. For BRCA1 mutation carriers, cumulative estimates of developing cancer by age 70 vary by population, ranging from 40% to 85% for breast cancer and 10% to 59% for ovarian cancer. For BRCA2 (show BRCA2 Proteins) mutation carriers, cumulative estimates of developing cancer are 45% to 57% for breast cancer and 11% to 18% for ovarian cancer.

  3. Data show that 11 breast cancer patients were mutated in BRCA1/2 genes, and 29 were not associated to BRCA1/2 mutations.

  4. Germline mutation in BRCA1 gene is associated with familial breast cancer.

  5. Study provides evidence that the prevalence of BRCA1 and BRCA2 (show BRCA2 Proteins) mutations is high in triple-negative breast cancer patients.

  6. BRCA1 mutation is associated with Familial Pancreatic Cancer.

  7. results established a cell type-specific function of DeltaNp63alpha in induction of quiescence and downregulation of the BRCA1 pathway which suggested a role of DeltaNp63alpha in the dormancy of luminal breast cancers.

  8. BRCA1 mutation is associated with perturbation in telomere biology resulting in breast cancer.

  9. overexpression of BRCA1 significantly inhibited expression of AR through activation of SIRT1 (show SIRT1 Proteins) in breast cancer cells

  10. BRCA1 mutation is associated with risk of breast and ovarian cancer.

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Protein Profile

Protein Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1)
  • breast cancer 1, early onset (BRCA1)
  • breast cancer 1, early onset (Brca1)
  • BRCAI protein
  • BRCC1 protein
  • BROVCA1 protein
  • IRIS protein
  • PNCA4 protein
  • PPP1R53 protein
  • PSCP protein
  • RNF53 protein

Protein level used designations for Breast Cancer 1 Proteins (BRCA1)

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

GENE ID SPECIES
12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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