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Browse our BRCA1 Proteins (BRCA1)

Full name:
Breast Cancer 1 Proteins (BRCA1)
On are 10 Breast Cancer 1 (BRCA1) Proteins from 6 different suppliers available. Additionally we are shipping BRCA1 Antibodies (563) and BRCA1 Kits (28) and many more products for this protein. A total of 616 BRCA1 products are currently listed.
list all proteins Gene Name GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

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BRCA1 Proteins (BRCA1) by Origin

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More Proteins for BRCA1 Interaction Partners

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  2. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  3. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (show COBRA1 Proteins)-dependent transcription program during mammary gland development.

  4. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  5. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  6. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Proteins) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

  7. Data show that mammary tumors resembling BRCA1-associated metaplastic breast carcinoma display intrinsic resistance to the poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) inhibitor olaparib as a result of increased P-glycoprotein drug efflux transporter expression.

  8. Downregulation of BRCA1 protein levels was a result of endoplasmic reticulum stress.

  9. BRCA1 regulated cell cycle checkpoints in a manner dependent on the 26S proteasome (show Psmd4 Proteins) activity.

  10. work therefore ascribes novel roles for BRCA1 and CtIP (show RBBP8 Proteins) in end-processing and fusion reactions at uncapped telomeres

Human Breast Cancer 1 (BRCA1) interaction partners

  1. ERCC1 (show ERCC1 Proteins) and BRCA1 were overexpressed in A549/DDP (show TIMM8A Proteins) compared with A549 (P<0.05). ERCC1 (show ERCC1 Proteins) and BRCA1siRNA transfection can significantly reduce ERCC1 (show ERCC1 Proteins) and BRCA1 mRNA and protein expression (P<0.05). Downregulating ERCC1 (show ERCC1 Proteins) and BRCA1 expression obviously inhibited cell proliferation and increased caspase 3 (show CASP3 Proteins) activity (P<0.05). Downregulating ERCC1 (show ERCC1 Proteins) and BRCA1 significantly decreased PI3K (show PIK3CA Proteins) and AKT (show AKT1 Proteins) phosphorylation levels (P<0.05).

  2. Association of BRCA1 single nucleotide polymorphisms with the breast cancer risk in the Bangladeshi population

  3. Rates of BRCA1 and BRCA2 (show BRCA2 Proteins) mutation testing are increasing in young women with breast cancer. Given that knowledge and concern about genetic risk influence surgical decisions and may affect systemic therapy trial eligibility, all young women with breast cancer should be counseled and offered genetic testing, consistent with the National Comprehensive Cancer Network guidelines.

  4. The number of patients with uninformative BRCA genetic test(BRCA1 and BRCA2 (show BRCA2 Proteins)) results in this study is typical of reported high-risk screening populations. Next-generation sequencing has ushered in a new era of broad-spectrum testing for the growing list of potential genetic etiologies for breast cancer beyond BRCA

  5. Authors investigated the effects of miR-342 transfection in the triple-negative breast cancer cell lines MDA-MB-231 and HCC1937, the latter carrying a germ-line BRCA1 mutation.

  6. Data show that mutations in BRCA1 exon 11 were found in 18 out of 263 breast cancer patients.

  7. high success rate of 81 % (21/26 test centers) demonstrates that BRCA1/2 multicenter mutation testing is well feasible in FFPE tumor tissue

  8. BRCA1 and SETDB1 (show SETDB1 Proteins) stand out as the most significant prognostic markers in this group of patients

  9. Low BRCA1 mRNA is associated with head and neck cancer.

  10. BRCA1 mutation is associated with Breast Cancer.

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Protein Profile

Protein Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1)
  • breast cancer 1, early onset (BRCA1)
  • breast cancer 1, early onset (Brca1)
  • BRCAI protein
  • BRCC1 protein
  • BROVCA1 protein
  • IRIS protein
  • PNCA4 protein
  • PPP1R53 protein
  • PSCP protein
  • RNF53 protein

Protein level used designations for Breast Cancer 1 Proteins (BRCA1)

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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