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Browse our BRCA1 Proteins (BRCA1)

Full name:
Breast Cancer 1 Proteins (BRCA1)
On www.antibodies-online.com are 10 Breast Cancer 1 (BRCA1) Proteins from 6 different suppliers available. Additionally we are shipping BRCA1 Antibodies (564) and BRCA1 Kits (30) and many more products for this protein. A total of 619 BRCA1 products are currently listed.
Synonyms:
BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53
list all proteins Gene Name GeneID UniProt
BRCA1 12189 P48754
BRCA1 672 P38398
BRCA1 497672 O54952

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BRCA1 Proteins (BRCA1) by Origin

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More Proteins for BRCA1 Interaction Partners

Mouse (Murine) Breast Cancer 1 (BRCA1) interaction partners

  1. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  2. loss of Brca1, a tumor suppressor that functions in DNA damage repair, in the mammary epithelium induced senescence with induction of p16 and a decline of stem cell function, which was rescued by p16 loss.

  3. Brca1-Wwox (show WWOX Proteins) interaction supports non-homologous end-joining as the dominant DSB repair pathway in Wwox (show WWOX Proteins)-sufficient cells

  4. Structure-guided separation-of-function mutations show that the RNF8 E2 stimulating activity is essential for DSB signaling in mammalian cells and is necessary for downstream recruitment of 53BP1 and BRCA1.

  5. Results reveal a broader biological role for BRCA1 in protecting the developing embryo from oxidative stress, and corroborate a role for DNA damage in the mechanism of ethanol embryotoxicity.

  6. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 in antagonizing COBRA1 (show COBRA1 Proteins)-dependent transcription program during mammary gland development.

  7. loss of Brca1 in murine BM causes hematopoietic defects similar to those seen in people with FA, which provides strong evidence that Brca1 is critical for normal hematopoiesis and that Brca1 is a bona fide FA-like gene.

  8. The Brca1 pathway is dysregulated in spinal cord microglia from hSOD1G93A mice. Brca1 was upregulated at 90 days of age when microgliosis became evident.

  9. Brca1(GC-/-) models reveal that specific intra-follicular Brca1 loss alone, or combined with cancer-promoting genetic (Trp53 (show TP53 Proteins) loss) and endocrine (high serum follicle-stimulating hormone) changes, was not sufficient to cause ovarian tumors.

  10. Data show that mammary tumors resembling BRCA1-associated metaplastic breast carcinoma display intrinsic resistance to the poly(ADP-ribose) polymerase (PARP (show PARP1 Proteins)) inhibitor olaparib as a result of increased P-glycoprotein drug efflux transporter expression.

Human Breast Cancer 1 (BRCA1) interaction partners

  1. Our aim was to set up a cost-effective and low time-consuming BRCA1-BRCA2 (show BRCA2 Proteins) mutation detection workflow using the Ion Torrent PGM (show Vcan Proteins) technology. A retrospective cohort of 40 patients with familial breast/ovarian cancer previously tested by Sanger sequencing and a prospective cohort of 72 patients (validation set) were analyzed.

  2. In order to characterize this deletion as a founder mutation, haplotype analysis was conducted in 60 carriers from 35 families, using three BRCA1 intragenic microsatellite markers and four markers surrounding the BRCA1 locus. Our results demonstrate a common shared core disease-associated haplotype of 2.89Mb

  3. We report here elevated recombination rates at telomeres in cells from human BRCA1 mutation carriers and in mouse embryonic stem cells lacking both copies of functional Brca1.

  4. CDK9 is a player in the DNA damage response and is consistent with its participation in homology-directed recombination pathway by modulating BRCA1 response.

  5. This is the largest study in Cyprus evaluating the prevalence and spectrum of BRCA1/2 mutations. Thirteen percent of the patients tested were positive for deleterious mutations which are within the range reported in other countries

  6. We conclude that the prophylactic oophorectomies performed between 1999 and 2010 as a result of widespread BRCA1 mutation testing have reduced the incidence of ovarian cancer in Pomerania by a small amount (about 1.6%), and that the impact of genetic testing will increase in the coming years.

  7. this study strengthens the use of yeast as model system to characterize the mechanisms leading to cancer in humans carrying the BRCA1 missense variant.

  8. Results indicate that COUP-TFII may play an oncogenic role in RCC, and COUP-TFII may promote tumor progression through inhibiting BRCA1.

  9. We studied effect of food on ABT-767 bioavailability in subjects with advanced BRCA1 or BRCA2 (show BRCA2 Proteins) mutated solid tumors or high grade serous ovarian, primary peritoneal or fallopian tube cancer

  10. the interplay between 53BP1/NHEJ and BRCA1/HR is of great relevance for tumor treatment, as the 53BP1 status would be highly important for the treatment response of BRCA1-associated tumors.

Cow (Bovine) Breast Cancer 1 (BRCA1) interaction partners

  1. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle.

  2. The gene-specific SNP marker analysis showed a significant association of BRCA1 C28300A with milk somatic cell scores.

  3. In general, OC use, childbearing and breastfeeding do not differ between BRCA1/2 carriers and non-carriers with ovarian cancer. However, the effects of tubal ligation may differ between BRCA1 carriers and non-carriers.

  4. Bovine BRCA1 was phosphorylated and nuclear speckling was enhanced in response to DNA-damaging agents.These results provide evidence that phosphorylation and nuclear relocalization are highly conserved features of the BRCA1 response to genotoxic stress.

Pig (Porcine) Breast Cancer 1 (BRCA1) interaction partners

  1. Consensus-based recombinant adeno-associated virus-BRCA1 knock out virus vectors failed to induce BRCA1 knockout in Gottingen fibroblasts.

BRCA1 Protein Profile

Protein Summary

This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.

Alternative names and synonyms associated with BRCA1

  • breast cancer 1 (Brca1)
  • breast cancer 1, early onset (BRCA1)
  • breast cancer 1, early onset (Brca1)
  • BRCAI protein
  • BRCC1 protein
  • BROVCA1 protein
  • IRIS protein
  • PNCA4 protein
  • PPP1R53 protein
  • PSCP protein
  • RNF53 protein

Protein level used designations for Breast Cancer 1 Proteins (BRCA1)

breast cancer associated 1 , breast cancer type 1 susceptibility protein homolog , BRCA1/BRCA2-containing complex, subunit 1 , RING finger protein 53 , breast and ovarian cancer susceptibility protein 1 , breast and ovarian cancer sususceptibility protein 1 , breast cancer type 1 susceptibility protein , protein phosphatase 1, regulatory subunit 53 , BRCA1 homologue , BRCA1 homolog

GENE ID SPECIES
12189 Mus musculus
672 Homo sapiens
497672 Rattus norvegicus
353120 Bos taurus
403437 Canis lupus familiaris
100049662 Sus scrofa
449497 Pan troglodytes
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