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Browse our BTRC Proteins (BTRC)

Full name:
beta-Transducin Repeat Containing Proteins (BTRC)
On are 3 beta-Transducin Repeat Containing (BTRC) Proteins from 2 different suppliers available. Additionally we are shipping BTRC Antibodies (50) and BTRC Kits (17) and many more products for this protein. A total of 71 BTRC products are currently listed.
b-TrCP, BETA-TRCP, Beta-Trcp1, betaTrCP, btrc, btrc-a, bTrCP, bTrCP1, Fbw1a, FBXW1, FBXW1A, FWD1, HOS, mKIAA4123, Slimb
list all proteins Gene Name GeneID UniProt
BTRC 8945 Q9Y297
Rat BTRC BTRC 361765  
BTRC 12234 Q3ULA2

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BTRC Proteins (BTRC) by Origin

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More Proteins for BTRC Interaction Partners

Xenopus laevis beta-Transducin Repeat Containing (BTRC) interaction partners

  1. Strong ERK (show MAPK1 Proteins) activation can target Cdc25A (show CDC25A Proteins) for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 Proteins) for cell cycle arrest.

Human beta-Transducin Repeat Containing (BTRC) interaction partners

  1. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth

  2. This study showed SCF (show KITLG Proteins)(beta-TRCP) earmarks Set8 (show SETD8 Proteins) for ubiquitination and degradation in a casein kinase I (show CSNK1D Proteins)-dependent manner, which is activated by DNA-damaging agents.

  3. SCF (show KITLG Proteins)(beta-TrCP1/2) interacting partners, were identified.

  4. a model that CD166 (show ALCAM Proteins) regulates MCAM (show MCAM Proteins) through a signaling flow from activation of PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) and c-Raf (show RAF1 Proteins)/MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) signaling to the inhibition of potential MCAM (show MCAM Proteins) ubiquitin E3 ligases, betaTrCP and Smurf1 (show SMURF1 Proteins).

  5. Human rotavirus NSP1 (show SH2D3A Proteins) functions by mimicking the host IkappaB phosphodegron recognized by beta-TrCP.

  6. Interaction between the phosphorylated degron motif of TRIM9 (show TRIM9 Proteins) and the WD40 (show DCAF12L2 Proteins) repeat region of beta-TrCP prevented beta-TrCP from binding its substrates, stabilizing IkappaBalpha (show NFKBIA Proteins) and p100 (show CUX1 Proteins) and thereby blocking NF-kappaB (show NFKB1 Proteins) activation.

  7. These results show that human rotaviruses commonly inhibit the NF-kappaB (show NFKB1 Proteins) pathway via their NSP1 (show SH2D3A Proteins) protein by degrading beta-TrCP and thus stabilizing IkappaB.

  8. No evidence of a direct association between beta-TRCP polymorphisms and breast cancer.

  9. identified 221 proteins that contained the DpSGXX(X)pS motif and also interacted specifically with the WD40 (show DCAF12L2 Proteins) repeats of betaTrCP.

  10. beta-TrCP has an important role in controlling H3K27 trimethylation activity and lymphoma pathogenesis by targeting EZH2 (show EZH2 Proteins) for degradation.

Mouse (Murine) beta-Transducin Repeat Containing (BTRC) interaction partners

  1. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth

  2. Erbin (show ERBB2IP Proteins) as a novel substrate of SAG (show RNF7 Proteins)-betaTrCP E3 ligase.

  3. these results clearly suggest that both beta-TrCP- and Hrd1 (show SYVN1 Proteins)-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Proteins) to maintain cellular homeostasis.

  4. beta-TrCP may be an essential player in UVB induced responses in skin

  5. Glycogen synthase kinase 3 (show GSK3a Proteins) phosphorylates a group of Ser (show SIGLEC1 Proteins) residues in the Neh6 domain of mouse Nrf2 (show NFE2L2 Proteins) that overlap with an SCF (show KITLG Proteins)/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1 (show KEAP1 Proteins)-independent manner.

  6. LPS (show TLR4 Proteins) appears to destabilize the LPCAT1 (show LPCAT1 Proteins) protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.

  7. the two beta-TrCP paralogs have a nonredundant role in spermatogenesis

  8. anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF (show KITLG Proteins)(beta-TrCP)

  9. BMP-2 (show BMP2 Proteins) modulates beta-catenin (show CTNNB1 Proteins) signaling through stimulation of Lrp5 (show LRP5 Proteins) expression and inhibition of beta-TrCP expression in osteoblasts

  10. Results suggest a role for Btrc in regulating the eventual ratio of resulting differentiated retinal cell types.

BTRC Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Alternative names and synonyms associated with BTRC

  • beta-transducin repeat containing (BTRC)
  • beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC)
  • beta-transducin repeat containing E3 ubiquitin protein ligase (btrc)
  • beta-transducin repeat containing (btrc)
  • beta-transducin repeat containing E3 ubiquitin protein ligase (Btrc)
  • beta-transducin repeat containing protein (Btrc)
  • b-TrCP protein
  • BETA-TRCP protein
  • Beta-Trcp1 protein
  • betaTrCP protein
  • btrc protein
  • btrc-a protein
  • bTrCP protein
  • bTrCP1 protein
  • Fbw1a protein
  • FBXW1 protein
  • FBXW1A protein
  • FWD1 protein
  • HOS protein
  • mKIAA4123 protein
  • Slimb protein

Protein level used designations for BTRC

beta-transducin repeat containing , beta-transducin repeat containing protein , F-box/WD repeat-containing protein 1A , f-box/WD repeat-containing protein 1A-like , E3RSIkappaB , F-box and WD repeats protein beta-TrCP , F-box and WD-repeat protein 1B , beta-TrCP1 , epididymis tissue protein Li 2a , pIkappaBalpha-E3 receptor subunit , beta-TrCP , beta-transducin repeat-containing protein , SCF b-TRCP , beta-TrCP protein E3RS-IkappaB , mE3RS-IkappaB , pIkappaB-E3 receptor subunit , ubiquitin ligase FWD1

423854 Gallus gallus
450685 Pan troglodytes
486851 Canis lupus familiaris
534072 Bos taurus
549140 Xenopus (Silurana) tropicalis
100171847 Pongo abelii
100337561 Xenopus laevis
100470916 Ailuropoda melanoleuca
100157842 Sus scrofa
100634006 Amphimedon queenslandica
8945 Homo sapiens
361765 Rattus norvegicus
394362 Xenopus laevis
100350519 Oryctolagus cuniculus
100730107 Cavia porcellus
101101939 Ovis aries
12234 Mus musculus
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