Browse our BTRC Proteins (BTRC)

On are 3 beta-Transducin Repeat Containing (BTRC) Proteins from 2 different suppliers available. Additionally we are shipping BTRC Antibodies (49) and BTRC Kits (14) and many more products for this protein. A total of 69 BTRC products are currently listed.
b-TrCP, BETA-TRCP, Beta-Trcp1, betaTrCP, btrc, btrc-a, bTrCP, bTrCP1, Fbw1a, FBXW1, FBXW1A, FWD1, HOS, mKIAA4123, Slimb
list all proteins Gene Name GeneID UniProt
BTRC 8945 Q9Y297
Rat BTRC BTRC 361765  
BTRC 12234 Q3ULA2

BTRC Proteins (BTRC) by Origin

More Proteins for BTRC Interaction Partners

Xenopus laevis beta-Transducin Repeat Containing (BTRC) interaction partners

  1. Strong ERK (show MAPK1 Proteins) activation can target Cdc25A (show CDC25A Proteins) for degradation in a manner similar to, but independent of, Chk1 (show CHEK1 Proteins) for cell cycle arrest.

Human beta-Transducin Repeat Containing (BTRC) interaction partners

  1. It demonstrates that degradation of Lipin-1 (show LPIN1 Proteins) is regulated by BTRC in the cytoplasm and on membranes

  2. we identified two independent SNPs (i.e., WNT2B (show WNT2B Proteins) rs1175649 G>T and BTRC rs61873997 G>A) that showed a predictive role in CM-specific survival, with an effect-allele-attributed hazards ratio (adjusted hazards ratio) of 1.99 (95% confidence interval = 1.41-2.81, P = 8.10 x 10(-5)) and 0.61 (0.46-0.80, 3.12x10(-4)), respectively.

  3. It has been proposed that CENP-W (show CENPW Proteins) may function as a booster of beta-TrCP1 nuclear import to increase the oncogenicity of beta-TrCP1.

  4. oncogenic effect of miR (show MLXIP Proteins)-182 and its reversal by beta-TrCP2 were confirmed in vivo This study suggests that beta-TrCP and miR (show MLXIP Proteins)-182 may be possible biomarkers and targets for early detection and treatment of pancreatic cancer

  5. Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H (show CREB3L3 Proteins).

  6. Phosphorylated VEGFR-2 (show KDR Proteins) was reduced by hyperglycemia while total VEGFR-2 (show KDR Proteins) was almost unaltered. However, VEGFR-2 (show KDR Proteins) was reduced when directly exposed to reactive oxygen species, with resultant co-location of beta-TrCP and VEGFR-2 (show KDR Proteins).

  7. Low GAS7C increases cancer cell motility by promoting N-WASP (show WASL Proteins)/FAK (show PTK2 Proteins)/F-actin cytoskeleton dynamics. It also enhances beta-catenin (show CTNNB1 Proteins) stability via hnRNP U (show HNRNPU Proteins)/beta-TrCP complex formation.

  8. EBV-miR (show MLXIP Proteins)-BART10-3p facilitated epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC.

  9. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth

  10. This study showed SCF (show KITLG Proteins)(beta-TRCP) earmarks Set8 (show SETD8 Proteins) for ubiquitination and degradation in a casein kinase I (show CSNK1D Proteins)-dependent manner, which is activated by DNA-damaging agents.

Mouse (Murine) beta-Transducin Repeat Containing (BTRC) interaction partners

  1. betaTrCP levels are correlated with imiquimod-induced skin lesion.

  2. beta-TrCP1/FWD1 dominant negative mutant has a role in reducing myeloma cell growth

  3. Erbin (show ERBB2IP Proteins) as a novel substrate of SAG (show RNF7 Proteins)-betaTrCP E3 ligase.

  4. these results clearly suggest that both beta-TrCP- and Hrd1 (show SYVN1 Proteins)-dependent degradation mechanisms regulate the transcriptional activity of Nrf1 (show NRF1 Proteins) to maintain cellular homeostasis.

  5. beta-TrCP may be an essential player in UVB induced responses in skin

  6. Glycogen synthase kinase 3 (show GSK3a Proteins) phosphorylates a group of Ser (show SIGLEC1 Proteins) residues in the Neh6 domain of mouse Nrf2 (show NFE2L2 Proteins) that overlap with an SCF (show KITLG Proteins)/beta-TrCP destruction motif (DSGIS, residues 334 to 338) and promotes its degradation in a Keap1 (show KEAP1 Proteins)-independent manner.

  7. LPS (show TLR4 Proteins) appears to destabilize the LPCAT1 (show LPCAT1 Proteins) protein by GSK-3beta-mediated phosphorylation within a canonical phosphodegron for beta-TrCP docking and site-specific ubiquitination.

  8. the two beta-TrCP paralogs have a nonredundant role in spermatogenesis

  9. anti-inflammatory effects of H(2)O(2) may result from its ability to decrease ubiquitination as well as subsequent degradation of I kappaB alpha through inhibiting the association between I kappaB alpha and SCF (show KITLG Proteins)(beta-TrCP)

  10. BMP-2 (show BMP2 Proteins) modulates beta-catenin (show CTNNB1 Proteins) signaling through stimulation of Lrp5 (show LRP5 Proteins) expression and inhibition of beta-TrCP expression in osteoblasts

BTRC Protein Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Alternative names and synonyms associated with BTRC

  • beta-transducin repeat containing (BTRC)
  • beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC)
  • beta-transducin repeat containing E3 ubiquitin protein ligase (btrc)
  • beta-transducin repeat containing (btrc)
  • beta-transducin repeat containing E3 ubiquitin protein ligase (Btrc)
  • beta-transducin repeat containing protein (Btrc)
  • b-TrCP protein
  • BETA-TRCP protein
  • Beta-Trcp1 protein
  • betaTrCP protein
  • btrc protein
  • btrc-a protein
  • bTrCP protein
  • bTrCP1 protein
  • Fbw1a protein
  • FBXW1 protein
  • FBXW1A protein
  • FWD1 protein
  • HOS protein
  • mKIAA4123 protein
  • Slimb protein

Protein level used designations for BTRC

beta-transducin repeat containing , beta-transducin repeat containing protein , F-box/WD repeat-containing protein 1A , f-box/WD repeat-containing protein 1A-like , E3RSIkappaB , F-box and WD repeats protein beta-TrCP , F-box and WD-repeat protein 1B , beta-TrCP1 , epididymis tissue protein Li 2a , pIkappaBalpha-E3 receptor subunit , beta-TrCP , beta-transducin repeat-containing protein , SCF b-TRCP , beta-TrCP protein E3RS-IkappaB , mE3RS-IkappaB , pIkappaB-E3 receptor subunit , ubiquitin ligase FWD1

423854 Gallus gallus
450685 Pan troglodytes
486851 Canis lupus familiaris
534072 Bos taurus
549140 Xenopus (Silurana) tropicalis
100171847 Pongo abelii
100337561 Xenopus laevis
100470916 Ailuropoda melanoleuca
100157842 Sus scrofa
100634006 Amphimedon queenslandica
8945 Homo sapiens
361765 Rattus norvegicus
394362 Xenopus laevis
100350519 Oryctolagus cuniculus
100730107 Cavia porcellus
101101939 Ovis aries
12234 Mus musculus
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