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Browse our CDK1 Proteins (CDK1)

Full name:
Cyclin-Dependent Kinase 1 Proteins (CDK1)
On are 25 Cyclin-Dependent Kinase 1 (CDK1) Proteins from 8 different suppliers available. Additionally we are shipping CDK1 Antibodies (764) and CDK1 Kits (41) and many more products for this protein. A total of 879 CDK1 products are currently listed.
5363, cdc, cdc-2, cdc2, cdc2-a, CDC2A, CDC2AAT, cdc2Dm, cdc2x1.1, cdc28a, CDCDm, Cdk-1, cdk1, CDK1/CDC2, CDK2, CDKA1, CDKA;1, cell division control 2, CG5363, CYCLIN-DEPENDENT KINASE A;1, Dcdc2, dCdk1, Dm cdc2, Dmcdc2, DmCdk1, Dmel\\CG5363, group 4, l(2)31Eh, p34, p34cdc2, POL3, pold, PSTAIR, wu:fc30e01, xcdc2, zgc:92032
list all proteins Gene Name GeneID UniProt
CDK1 983 P06493
CDK1 12534 P11440
CDK1 54237 P39951

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CDK1 Proteins (CDK1) by Origin

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Top referenced CDK1 Proteins

  1. Human CDK1 Protein expressed in Baculovirus infected Insect Cells - ABIN2003332 : Ubersax, Woodbury, Quang, Paraz, Blethrow, Shah, Shokat, Morgan: Targets of the cyclin-dependent kinase Cdk1. in Nature 2003 (PubMed)
    Show all 2 references for ABIN2003332

  2. Human CDK1 Protein expressed in Wheat germ - ABIN1348775 : Ovejero-Benito, Frade: Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. in PLoS ONE 2013 (PubMed)

More Proteins for CDK1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. Our results indicate that the cyclic changes in Gwl (show MASTL Proteins) localization at mitotic entry and exit are directly regulated by the antagonistic cyclin B-Cdk1 and PP2A (show PPP2R2B Proteins)-Tws enzymes

  2. Cdk1 mediates the role of TARA and CycA (show CCNA2 Proteins) in sleep regulation.

  3. Y15 phosphorylation can both inhibit Cdk1 catalytic activity and de-stabilize Cdk1/Cyclin (show PCNA Proteins) complexes, whereas T161 phosphorylation facilitates stable interactions between cyclin B and Cdk1.

  4. Phosphorylation of Cdk1 on Y15 appeared to be crucial for developmental and DNA damage-induced G2-phase checkpoint arrest, consistent with other evidence that Myt1 (show MYT1 Proteins) is the major Y15-directed Cdk1 inhibitory kinase at this stage of development.

  5. nonmuscle myosin II regulation by Cdc2 activity

  6. CDK1 activation may be the cell cycle regulated event that determines the timing of emi1 destruction.

  7. Data show that down-regulation of Cdc2 delayed pI mitosis and altered the polarity and the number of subsequent cell divisions.

  8. Data suggest that Cks30A interacts with Cdk1, and may regulate Cyclin A (show CCNA2 Proteins) levels through the activity of a female germline-specific anaphase-promoting complex, CDC20 (show CDC20 Proteins)-Cortex.

  9. Our findings suggest a model where mitotic disassembly/reassembly of the NPCs is regulated by a dynamic equilibrium of Cdk1 and OA-sensitive phosphatase activities and provide evidence that mitotic phosphorylation mediates disassembly of the NPC (show NPC1 Proteins).

  10. These results show that the two potential Cdk1 phosphorylation sites on Drosophila Cdc27 are required for its chromosomal localisation during mitosis and imply that these localisations specific to Cdc27 are crucial for APC (show APC Proteins)/C functions.

Human Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. Knockdown of DRG2 (show DRG2 Proteins) elicited down-regulation of the major mitotic promoting factor, the cyclin B1 (show CCNB1 Proteins)/Cdk1 complex.

  2. colon cancer-associated transcript 1/miR (show MLXIP Proteins)-490-3p/cyclin-dependent kinase 1 regulatory pathway promotes the progression of hepatocellular carcinoma.

  3. our results suggest that alteration of CDK1 expression on both mRNA and protein level probably appears on the very early step of carcinogenesis in laryngeal squamous cell carcinoma

  4. Mitochondrial Ribosomal Protein L10 regulates cyclin B1 (show CCNB1 Proteins)/Cdk1 (cyclin-dependent kinase 1) activity and mitochondrial protein (show COX6B2 Proteins) synthesis in mammalian cells

  5. Ajuba (show AJUBA Proteins) is phosphorylated in vitro and in vivo by cyclin-dependent kinase 1 (CDK1) at Ser (show SIGLEC1 Proteins)(119) and Ser (show SIGLEC1 Proteins)(175) during the G2/M phase of the cell cycle

  6. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.

  7. Data suggest that long non-coding RNA ZFAS1 may function as oncogene (show RAB1A Proteins) via destabilization of tumor suppressor protein p53 (p53 (show TP53 Proteins)) and through cyclin-dependent kinase 1 (CDK1)/cyclin B1 (show CCNB1 Proteins) complex leading to cell cycle progression and inhibition of apoptosis.

  8. Aurora B (show AURKB Proteins) may prefer Cdk1-phosphorylated Sororin (show CDCA5 Proteins) as a substrate.

  9. we discovered a novel mechanism mediated by Smad4 (show SMAD4 Proteins) to trigger 5-FU chemosensitivity through cell cycle arrest by inhibiting the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins)/CDC2/survivin (show BIRC5 Proteins) cascade.

  10. exposing renal carcinoma cells to amygdalin inhibited cell cycle progression and tumor cell growth by impairing cdk1 and cyclin B expression

Cow (Bovine) Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. Oligosaccharides of hyaluronan induce angiogenesis through distinct CD44 (show CD44 Proteins) and RHAMM (show HMMR Proteins)-mediated signalling pathways involving Cdc2 and gamma-adducin (show ADD3 Proteins).

Mouse (Murine) Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. oxidative stress-induced (show SQSTM1 Proteins) DNA damage of mouse zygotes triggers the cell cycle checkpoint, which results in G2/M cell cycle arrest, and that phospho-Cdc25B (show CDC25B Proteins) (Ser323), phospho-Cdc25C (show CDC25C Proteins) (Ser216), and phospho-Cdc2 (Tyr15) participate in activating the G2/M checkpoint.

  2. CDK1 is required upstream of a checkpoint-associated cell death as well as meiotic metaphase progression in mouse spermatocytes.

  3. CDK1 is a synthetic lethal target for KRAS mutant tumors.

  4. Our data demonstrate that ES cells are uniquely sensitive to CDK1 inhibition via a p53 (show TP53 Proteins)/NOXA (show PMAIP1 Proteins)/MCL1 (show MCL1 Proteins) pathway.

  5. Ubiquitin-dependent degradation of GATA 2 (show GATA2 Proteins) is promoted by Fbw7 (show FBXW7 Proteins), is cyclin B-CDK1-mediated Thr176 phosphorylation-dependent, and influences hematopoietic cell differentiation.

  6. HDAC3 (show HDAC3 Proteins) controls G2/M phase progression mainly through posttranslational stabilization of the G2/M cyclin-dependent kinase 1.

  7. Our findings reveal the following novel molecular mechanisms controlling mitochondrial fission during A/R injury of cardiomyocytes resulted from both increased activation Drp1 (show CRMP1 Proteins) through Cdk1, PKCdelta (show PKCd Proteins), and calcineurin (show PPP3CA Proteins)-mediated pathways, respectively

  8. CDK1 activation proceeds with concomitant inhibition by CDC6 (show CDC6 Proteins), which tunes the timing of the M-phase entry during the embryonic cell cycle

  9. FlnB (show FLNB Proteins) loss reduced Cdk1 phosphorylation (an inhibitor of G2/M phase progression) and Cdk1 inhibition in chondrocytes mimicked the null FlnB (show FLNB Proteins), premature differentiation phenotype, through a beta1-integrin receptor- Pi3k/Akt (show AKT1 Proteins) mediated pathway.

  10. CDK1-dependent phosphorylations required for the initiation of nuclear membrane disassembly during mitosis are adapted for removal of nuclei during fiber cell differentiation.

Zebrafish Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. intestinal clock controls the expression of key cell cycle regulators, such as cdc2, wee1 (show WEE1 Proteins), p21 (show CDKN1A Proteins), PCNA (show PCNA Proteins) and cdk2 (show CDK2 Proteins), but only weakly influences cyclin B1 (show CCNB1 Proteins), cyclin B2 (show CCNB2 Proteins) and cyclin E1 (show CCNE1 Proteins) expression.

Pig (Porcine) Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. CDK7 (show CDK7 Proteins) and CCNH (show CCNH Proteins) activate CDC2 by T161 phosphorylation and make up CDK-activating kinase (show CDK7 Proteins), which is required for normal meiotic progression during porcine oocyte maturation.

  2. Results describe the expression of maternal cyclin B1 (show CCNB1 Proteins) and Cdc2 during in vitro maturation of porcine oocytes.

  3. Data demonstrate the presence of a novel structure in the cortex of porcine oocytes that comprises ERES and transiently accumulates CDC2 prior to germinal vesicle breakdown.

  4. insufficient amount of Cdc2 and continuous activation of Wee1 B are the cause of meiotic failure of small oocytes in pigs

  5. These results suggest that the inhibitory phosphorylation of CDC2, which is catalyzed by pigWee1B (show WEE2 Proteins), but not pigMyt1, is involved in the meiotic arrest of porcine oocytes.

Xenopus laevis Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. the fine-tuning of Cdc6 (show CDC6 Proteins) accumulation is essential to ensure two meiotic waves of Cdk1 activation and to avoid unscheduled DNA replication during meiotic maturation.

  2. equilibrium between CDK1 and PP2A (show PPP2R2B Proteins) specifies the timing of M-phase entry and exit and regulates the dynamics of cyclin B degradation upon M-phase exit in Xenopus laevis first embryonic mitosis.

  3. CDK1 activation proceeds with concomitant inhibition by CDC6 (show CDC6 Proteins), which tunes the timing of the M-phase entry during the embryonic cell cycle

  4. Xenopus Cdk1-AS rescues HT2-19 cells from apoptosis.

  5. Ras suppresses cyclin-dependent kinase 1 in a complex manner: It induces continuous accumulation of cyclin B2 (show CCNB2 Proteins), but also causes persistent inhibitory phosphorylation of tyr (show TYR Proteins)-15-cyclin-dependent kinase 1.

  6. By promoting CtIP (show RBBP8 Proteins)-dependent resection of double-strand break (DSB) ends while preventing Rad51 chromatin assembly, Cdk1 inhibits both the nonhomologous and homologous modes of DSB repair during mitosis.

  7. Examination of H1 histones reveals isoform-specific regulation by Cdk1 and RanGTP; mitotic Cdk1 functions to enhance H1 binding in egg extracts and embryos

  8. Cdc2 displays cytoskeleton-dependent localization in blastomere cortex during Xenopus embryonic cell cycle.

  9. Results suggest that the specific synthesis of either B-type cyclins or c-Mos (show MOS Proteins), induced by progesterone, is required to induce meiotic maturation and Cdc2 activation.

  10. Cyclin B dissociation from CDK1 precedes cyclins B degradation upon CDK1 inactivation in mitotic embryo extracts and that proteasome proteolytic activity is dispensable for both activation and inactivation of CDK1 in such extracts.

Arabidopsis thaliana Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. CDKA;1 and CYCD3;2 are required for the terminal division in the stomatal lineage.

  2. Data indicate that the in vivo confirmation of substrates of CDKA;1 showing a direct link between cell proliferation and the control of the redox state.

  3. The crucial function of CDKA;1 is the control of the plant Retinoblastoma homolog RBR1 and codepletion of RBR1 and CDKA;1 rescued most defects of cdka;1 mutants.

  4. Expression of a dominant negative CDKA;1 allele under the control of the STM (show SHMT1 Proteins) promoter perturbs post-embryonic development. Inhibition of CDK (show CDK4 Proteins) activity at the shoot apex (show APEX1 Proteins) results in premature differentiation of shoot apical meristem cells.

  5. When a single cdka;1 sperm was delivered, either female gamete could be fertilized leading to similar proportions of seeds containing either a single endosperm or a single embryo.

  6. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1.

  7. CDC2A participates in the fertilization process of endosperm

  8. The balance between cell division and differentiation is regulated through the interaction between CDKA;1 and the antiphosphatase PAS2. [CDKA;1]

  9. The Arabidopsis thaliana Cdc2(+)/Cdc28 homolog CDKA;1 is also phosphorylated in the T-loop and that phosphorylation at the conserved Thr (show TRH Proteins)-161 residue is essential for its function.

  10. phosphorylation of T161 in Arabidopsis CDKA;1 is essential for cell division during male gametogenesis

Caenorhabditis elegans (C. elegans) Cyclin-Dependent Kinase 1 (CDK1) interaction partners

  1. These results reveal a crucial and conserved role of phosphorylation of the N terminus of Bora for Plk1 activation and mitotic entry.

  2. CDK-1 regulates PLK-1 activity during mitosis in C. elegans embryos through multisite phosphorylation of the PLK-1 activator SPAT (show AGXT Proteins)-1

  3. Conversion of microtubule-organizing center state involves the conserved C. elegans centrosome protein SPD-2/CEP192 and cell-cycle-dependent kinase activity from the mitotic cell.

  4. Our results support a model in which CYB (show CSTB Proteins)-2.1/2/CDK-1 antagonize CUL-2 (show CUL2 Proteins) activity to promote stabilization of PAR-6 (show PARD6A Proteins) levels during polarization of the early C. elegans embryo.

  5. CDK-1 activates PLK-1 via SPAT (show AGXT Proteins)-1 phosphorylation to promote entry into mitosis.

  6. model in which Wnt signaling and CDK-1 modify WRM-1 in a temporal and spatial manner to unmask an intrinsic polarity cue required for proper orientation of the endomesoderm cell division axis

  7. results indicate that CDC-25.1 is required for maintaining proper rate of germline mitotic cell cycle; propose that CDC-25.1 regulates the rate of germline mitotic cell cycle by counteracting WEE (show WEE1 Proteins)-1.3 and by positively controlling CDK-1

  8. CDK-1 blocks rotation by inhibiting dynein association with microtubules.

  9. Use of loss- and gain-of-function genetic approaches demonstrates that CYY-1, a cyclin (show PCNA Proteins) box-containing protein, drives synapse removal in this process.

  10. NPP-16 and CDK-1 function to arrest prophase blastomeres in C. elegans embryos

CDK1 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with CDK1

  • cyclin-dependent kinase 1 (PtrCDKA-1)
  • cell division control protein2 homolog (cdc2)
  • CG5363 gene product from transcript CG5363-RA (cdc2)
  • cyclin-dependent kinase 1 (CDK1)
  • cyclin-dependent kinase 1 (Cdk1)
  • cyclin-dependent kinase 1 (cdk1)
  • cyclin-dependent kinase 1 (cdk1-a)
  • cyclin-dependent kinase A-1 (CDC2)
  • cyclin-dependent kinase-like 1 (LOC100346649)
  • polymerase (DNA directed), delta 1, catalytic subunit (pold1)
  • Protein CDK-1 (cdk-1)
  • 5363 protein
  • cdc protein
  • cdc-2 protein
  • cdc2 protein
  • cdc2-a protein
  • CDC2A protein
  • CDC2AAT protein
  • cdc2Dm protein
  • cdc2x1.1 protein
  • cdc28a protein
  • CDCDm protein
  • Cdk-1 protein
  • cdk1 protein
  • CDK1/CDC2 protein
  • CDK2 protein
  • CDKA1 protein
  • CDKA;1 protein
  • cell division control 2 protein
  • CG5363 protein
  • Dcdc2 protein
  • dCdk1 protein
  • Dm cdc2 protein
  • Dmcdc2 protein
  • DmCdk1 protein
  • Dmel\\CG5363 protein
  • group 4 protein
  • l(2)31Eh protein
  • p34 protein
  • p34cdc2 protein
  • POL3 protein
  • pold protein
  • PSTAIR protein
  • wu:fc30e01 protein
  • xcdc2 protein
  • zgc:92032 protein

Protein level used designations for CDK1

cyclin-dependent kinase 1 , PCO133105 , PCO133105_ov , cell division control protein 2 homolog , p34cdc2 , protein cdc2 kinase , putative cyclin-dependent kinase A family protein , CG5363-PA , cdc2 kinase , cdc2-PA , cyclin dependent kinase , cyclin-dependent kinase , cell cycle controller CDC2 , cell division cycle 2, G1 to S and G2 to M , cell division protein kinase 1 , p34 protein kinase , cell cycle p34 CDC2 kinase protein , cell division cycle 2 homolog A , cell division cycle control protein 2a , Cell division cycle control protein 2 , cell division cycle 2 , cell division cycle 2 protein , Cell division control protein 2 homolog 1 , cell division control protein 2-A , cell division cycle 2 like , cell division protein kinase 1-A , cyclin-dependent kinase 1-A , p34 protein kinase 1 , DNA polymerase delta , DNA-directed DNA polymerase delta 1 , polymerase (DNA directed), delta 1, catalytic subunit 125kDa

7472581 Populus trichocarpa
542270 Zea mays
34411 Drosophila melanogaster
983 Homo sapiens
281061 Bos taurus
12534 Mus musculus
54237 Rattus norvegicus
396252 Gallus gallus
80973 Danio rerio
488997 Canis lupus familiaris
100155762 Sus scrofa
100735946 Cavia porcellus
100861361 Capra hircus
100216432 Ovis aries
380246 Xenopus laevis
824036 Arabidopsis thaliana
100346649 Oryctolagus cuniculus
447518 Xenopus laevis
176374 Caenorhabditis elegans
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