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Browse our CDK4 Proteins (CDK4)

Full name:
Cyclin-Dependent Kinase 4 Proteins (CDK4)
On are 38 Cyclin-Dependent Kinase 4 (CDK4) Proteins from 14 different suppliers available. Additionally we are shipping CDK4 Antibodies (264) and CDK4 Kits (37) and many more products for this protein. A total of 352 CDK4 products are currently listed.
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726
list all proteins Gene Name GeneID UniProt
CDK4 1019 P11802
CDK4 12567 P30285
CDK4 94201 P35426

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CDK4 Proteins (CDK4) by Origin

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Top referenced CDK4 Proteins

  1. Human CDK4 Protein expressed in Escherichia coli (E. coli) - ABIN1098680 : Kato, Matsuoka, Strom, Sherr: Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. in Molecular and cellular biology 1994 (PubMed)
    Show all 2 references for ABIN1098680

  2. Human CDK4 Protein expressed in Wheat germ - ABIN1348950 : Bockstaele, Kooken, Libert, Paternot, Dumont, de Launoit, Roger, Coulonval: Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors". in Molecular and cellular biology 2006 (PubMed)

More Proteins for CDK4 Interaction Partners

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. concurrent inhibition of ESR1 (show ESR1 Proteins) and the cyclin (show PCNA Proteins)-dependent kinases 4 and 6 (CDK4/6) significantly increased progression-free survival in advanced patients

  2. amplification of HMGA2 was associated with the atypical lipomatous tumor/well-differentiated liposarcoma histological type and a good prognosis, whereas CDK4 and JUN (show JUN Proteins) amplifications were associated with dedifferentiated liposarcoma histology

  3. CDK4 Amplification Reduces Sensitivity to CDK4/6 Inhibition in Fusion-Positive Rhabdomyosarcoma

  4. Observations disclose the presence of CDK4 protein in human erythrocytes and its involvement in suicidal erythrocyte death.

  5. Ewing sarcoma cells require CDK4 and cyclin D1 (show CCND1 Proteins) for survival and anchorage-independent growth.

  6. Marine steroids as potential anticancer drug candidates: In silico investigation in search of inhibitors of Bcl-2 (show BCL2 Proteins) and CDK-4/Cyclin D1 (show CCND1 Proteins).

  7. Data show that the p16/CDKN2A-cyclin-dependent kinase 4 (CDK4)-RB1 (show RB1 Proteins) protein pathway is frequently disrupted in fibrosarcomatous dermatofibrosarcoma protuberans (FS-DFSP).

  8. The results of clinical trials with oral CDK4/6 inhibitors to date have offered promising glimpses of significant activity in hormone-sensitive breast cancer.

  9. shRNA-mediated knockdown or chemical inhibition of CDK4 prevented the increase in cell size associated with the senescent phenotype by allowing the cells to arrest in G1 rather than G2/M.

  10. Prevalence of Germline BAP1 (show RNF2 Proteins), CDKN2A, and CDK4 Mutations in an Australian Population-Based Sample of Cutaneous Melanoma Cases

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (show GJA1 Proteins) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. Cdk4 protein

  2. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (show SOD2 Proteins).

  3. a crucial role of RXRa in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS(Q61K) and altered expression of p53 and PTEN

  4. Our data indicate that Cdk2 (show CDK2 Proteins) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (show CDK1 Proteins) inhibitors for cancer therapy.

  5. CDK4 is a critical downstream target of MEN1 (show MEN1 Proteins)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (show CDK2 Proteins) is dispensable for tumorigenesis in these neuroendocrine cell types.

  6. Cdk4 and Cdk6 (show CDK6 Proteins) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (show CDK6 Proteins) in sequestering INK4 proteins away from Cdk4.

  7. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  8. insulin (show INS Proteins) activates cyclin D1 (show CCND1 Proteins)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (show KAT2A Proteins) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  9. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (show MYC Proteins) transgenic model of B lymphoma

  10. Cdk4- and Arf-mutant mice exhibited similar profiles, the Trp53(F/F) ::Tyr-Cre(ER)::Tyr-NRAS melanomas were strikingly different, showing relative down-regulation of melanocyte-related genes, and up-regulation of genes related to neural differentiation.

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) interaction partners

  1. The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.

  2. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (show NRF1 Proteins) and consequent induction of Tfam (show TFAM Proteins) and mitochondrial ribossomal transcription.

  3. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  4. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  5. mRpL12 (show MRPL12 Proteins) is required for CycD/Cdk4-induced cell growth

  6. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4)
  • cyclin-dependent kinase 4 (CDK4)
  • cyclin-dependent kinase 4 (Cdk4)
  • Cyclin-dependent kinase 4 (Cdk4)
  • 8-6 protein
  • cdk protein
  • cdk4 protein
  • cdk4/6 protein
  • CG5072 protein
  • CMM3 protein
  • Crk3 protein
  • dCdk4 protein
  • DmCdk4 protein
  • Dmel\\CG5072 protein
  • l(2)05428 protein
  • l(2)0671 protein
  • l(2)k06503 protein
  • l(2)s4639 protein
  • l(2)sh0671 protein
  • Pk53C protein
  • Pk?7 protein
  • PSK-J3 protein
  • xcdk4 protein
  • zgc:153726 protein

Protein level used designations for CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
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