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Human CDK6 ELISA Kit for Sandwich ELISA - ABIN417792
Berenjian, Hu, Abedi-Valugerdi, Hassan, Bashir Hassan, Morein: The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells. in Leukemia & lymphoma 2014
we verified that miR (show MLXIP ELISA Kits)-892b regulates the p19ARF/cyclin D1 (show CCND1 ELISA Kits)/CDK6 and Sp-1 (show PSG1 ELISA Kits)/MMP-9 (show MMP9 ELISA Kits) signaling networks in bladder cancer cells and may provide a treatment option for advanced-stage bladder cancers.
miR (show MLXIP ELISA Kits)-1299 inhibited CDK6 expression and bound to the 3'UTR (show UTS2R ELISA Kits) of CDK6.
Expression of miR (show MLXIP ELISA Kits)-26a and miR (show MLXIP ELISA Kits)-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7 (show ADAMTS7 ELISA Kits), ATP1B1 (show ATP1B1 ELISA Kits), COL4A2 (show COL4a2 ELISA Kits), CPEB3 (show CPEB3 ELISA Kits), CDK6, DNMT3a (show DNMT3A ELISA Kits) and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues.
Data indicate that microRNA miR (show MLXIP ELISA Kits)-214 has tumor-suppressive activity in hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) through inhibition of E2F2 transcription factor (E2F2 (show E2F2 ELISA Kits)), cyclin (show PCNA ELISA Kits)-dependent kinases CDK3 (show CDK3 ELISA Kits) and CDK6.
The concept that cotargeting MEK and CDK4/6 would prove efficacious in KRAS-mutant (KRAS(mt)) colorectal cancers.
Results show that NEAT1 regulated CDK6 expression in laryngeal squamous cell cancer (LSCC) cells which was mediated by miR (show MLXIP ELISA Kits)-107; NEAT1 plays an oncogenic role in the tumorigenesis of LSCC.
This review highlights our current understanding of CDK (show CDK4 ELISA Kits) signaling in both normal and malignant breast tissues, with special attention placed on recent clinical advances in inhibition of CDK4/6 (show CDK4 ELISA Kits) in ER+ disease
PHD1 (show EGLN2 ELISA Kits) is phosphorylated by CDK2 (show CDK2 ELISA Kits), CDK4 (show CDK4 ELISA Kits) and CDK6 at Serine 130.
A ZFP36L1 (show ZFP36L1 ELISA Kits)-mediated regulatory circuit through repressing CDK6 expression.
concurrent inhibition of ESR1 (show ESR1 ELISA Kits) and the cyclin (show PCNA ELISA Kits)-dependent kinases 4 and 6 (CDK4/6 (show CDK4 ELISA Kits)) significantly increased progression-free survival in advanced patients
Notch3 (show NOTCH3 ELISA Kits) transcription and growth of lymphoma cells was dependent on CDK6.
CDK6 is an important regulator of stem cell activation and an essential component of a transcriptional complex that suppresses Egr1 (show EGR1 ELISA Kits) in hematopoietic and leukemic stem cell activation
Cdk4 (show CDK4 ELISA Kits) and Cdk6 cooperate in hematopoietic tumor development and suggest a role for Cdk6 in sequestering INK4 proteins away from Cdk4 (show CDK4 ELISA Kits).
Cdk6/Ccnd1 (show CCND1 ELISA Kits) overexpression inhibits chondrocyte maturation and enhances G1/S transition by phosphorylating pRb (show PGR ELISA Kits); the chondrocytes then undergo p53 (show TP53 ELISA Kits)-dependent apoptosis
p107 (show RBL1 ELISA Kits) retinoblastoma protein is regulated by Cdk6/Ccnd1 (show CCND1 ELISA Kits) in growth plates.
A chrysin derivative suppresses skin cancer growth by inhibiting cyclin (show PCNA ELISA Kits)-dependent kinases.
Cdk6 deficiency prevents the expansion of neuronally committed precursors by lengthening G(1) phase duration, reducing concomitantly the production of newborn neurons
a mechanism for LPS (show TLR4 ELISA Kits) signaling which involves a decrease in miR (show MLXIP ELISA Kits)-107 leading to an increase in CDK6
an important role for CDK6 kinase activity in thymocyte development that operates partially through modulating Notch (show NOTCH1 ELISA Kits) target gene expression.
we identify CDK6 as relevant and critical target of AP-1 (show JUN ELISA Kits)-regulated DNA methylation (show HELLS ELISA Kits) on BCR-ABL (show ABL1 ELISA Kits)-induced transformation, thereby accelerating leukemogenesis
the T-1075C SNP of bovine CDK6 is significantly associated with body length and heart girth
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified.
cyclin-dependent kinase 6
, cell division protein kinase 6-like
, cell division protein kinase 6
, serine/threonine-protein kinase PLSTIRE
, CR2 protein kinase