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CDK6 Products

(Cyclin-Dependent Kinase 6 (CDK6))

Categories

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].

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Featured CDK6 Categories

CDK6 Antibodies

High quality antibodies with extensive validation data.

CDK6 ELISA Kits

Reliable ELISA kits for a wide range of species.

CDK6 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CDK6 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC, WB
Validations
  • (7)
Cat. No. ABIN7266595
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse
Application ICC, IF, IHC (p), WB
Validations
  • (2)
  • (5)
Cat. No. ABIN2855743
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, IHC
Validations
  • (8)
Cat. No. ABIN7259074
Quantity 200 μL
Datasheet Datasheet

Recommended CDK6 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6955160
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6966172
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6961992
Quantity 96 tests
Datasheet Datasheet

Recommended CDK6 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (2)
Cat. No. ABIN5569605
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3135584
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3091400
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CDK6 products

Bychkov, Shulepko, Vasileva, Sudarikova, Kirpichnikov, Lyukmanova: "ASIC1a Inhibitor mambalgin-2 Suppresses the Growth of Leukemia Cells by Cell Cycle Arrest." in: Acta naturae, Vol. 12, Issue 2, pp. 101-116, (2020) (PubMed).

Méndez-Barbero, Gutierrez-Muñoz, Madrigal-Matute, Mínguez, Egido, Michel, Martín-Ventura, Esteban, Blanco-Colio: "A major role of TWEAK/Fn14 axis as a therapeutic target for post-angioplasty restenosis." in: EBioMedicine, Vol. 46, pp. 274-289, (2020) (PubMed).

Wu, Xiong, Li, Yang, Ge et al.: "Integrated Proteomic and Transcriptomic Analysis Reveals Long Noncoding RNA HOX Transcript Antisense Intergenic RNA (HOTAIR) Promotes Hepatocellular Carcinoma Cell Proliferation by Regulating Opioid ..." in: Molecular & cellular proteomics : MCP, Vol. 17, Issue 1, pp. 146-159, (2019) (PubMed).

Ahonen, Haridas, Mysore, Wabitsch, Fischer-Posovszky, Olkkonen: "miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes." in: Molecular and cellular endocrinology, Vol. 479, pp. 110-116, (2019) (PubMed).

Li, Meng, Hao, Tao, Zou, Li, Ming, Ding, Dong, Feng, Li, Wang, Wu: "Immune regulation mechanism of Astragaloside IV on RAW264.7 cells through activating the NF-κB/MAPK signaling pathway." in: International immunopharmacology, Vol. 49, pp. 38-49, (2018) (PubMed).

Li, Wang, Yu, Wu, Hu, Wang, Ye: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." in: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).

Ren, Qiu, Lü, Ru, Li, Xiang, Yu, Zhang: "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." in: Scientific reports, Vol. 6, pp. 23775, (2017) (PubMed).

Li, Chen, Chen, Mo, Li, Xiao, Yu, Guo: "Circular RNA 0000096 affects cell growth and migration in gastric cancer." in: British journal of cancer, Vol. 116, Issue 5, pp. 626-633, (2017) (PubMed).

Zhang, Liu, Li, Cao, Wan, Xi, Li, Tan, Wang, Wu, Ma, Gao: "Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer." in: Journal of hematology & oncology, Vol. 10, Issue 1, pp. 29, (2017) (PubMed).

He, Zheng, Zhang, Gan, Zhou, Liang, Wu, Ge, Deng, Xu: "Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of γ-synuclein in hepatocellular carcinoma cells." in: Oncotarget, Vol. 8, Issue 6, pp. 9451-9465, (2016) (PubMed).

Synonyms and alternative names related to CDK6

cyclin dependent kinase 6 (CDK6), cyclin-dependent kinase 6 (Cdk6), 5830411I20, AI504062, CDK6, Crk2, PLSTIRE

Protein level used designations for CDK6

  • cyclin-dependent kinase 6
  • cell division protein kinase 6-like
  • cell division protein kinase 6
  • serine/threonine-protein kinase PLSTIRE
  • CR2 protein kinase
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