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anti-Human Cullin 1 Antibodies:
anti-Mouse (Murine) Cullin 1 Antibodies:
anti-Rat (Rattus) Cullin 1 Antibodies:
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Chicken Monoclonal Cullin 1 Primary Antibody for IF, WB - ABIN968721
Hatakeyama, Kitagawa, Nakayama, Shirane, Matsumoto, Hattori, Higashi, Nakano, Okumura, Onoé, Good, Nakayama: Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. in Proceedings of the National Academy of Sciences of the United States of America 1999
Show all 3 Pubmed References
Human Polyclonal Cullin 1 Primary Antibody for ICC, IF - ABIN4300962
Lutz, Pace, Arnold: Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases. in Journal of virology 2016
Human Polyclonal Cullin 1 Primary Antibody for WB - ABIN1537543
Jiang, He, Xu, Liu, Qu, Tong: Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer. in International journal of clinical and experimental pathology 2015
The SCF (show KITLG Antibodies)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 Antibodies).
Around the time of major gene activation, expression of cullin 1 switches from transcript variant 1 to transcript variant 3.
unneddylated Cul1 is another central player involved in maintenance of the adaptor module pool through the formation of Cul1-Skp-1 (show SKP1 Antibodies)-F-box complexes and promotion of rapid SCF (show KITLG Antibodies) assembly
Data suggest that cullin1 (Cul1) may constitute a potential therapeutic target in renal cell carcinoma (show MOK Antibodies) (RCC (show XRCC1 Antibodies)).
Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR (show DEPTOR Antibodies). eIF4F (show EIF4A2 Antibodies) suppression inhibited the promoting effect of Cul1 on melanoma cell proliferation.
Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.
High Cul1 expression predicts worse 5-year overall and disease-specific survival rates in HCC (show FAM126A Antibodies) patients.
Nedd8 (show NEDD8 Antibodies)(Q40E) cannot induce the same structural effect on Cul1-Rbx1 as wild-type Nedd8 (show NEDD8 Antibodies).
Cullin-1 has been deeply implicated in the pathogenesis and development of prostate cancer
Increased CUL1 expression in CRC (show CALR Antibodies) cells significantly promoted cell migration and invasion abilities in vitro and peritoneal metastasis in vivo through inducing high expression of MMPs.
Our data indicated that Cul1 expression significantly increased in human glioma, and it may be involved in proliferation, migration and invasion of glioma cells.
In papillary thyroid carcinoma, cytoplasmic expression of Cul1 was correlated with tumor occurrence, N stage and Cyclin D1 (show CCND1 Antibodies) expression. Nuclear Cul1 expression was negatively correlated with tumor occurence.
Cul-1 deneddylation led to Deptor (show DEPTOR Antibodies) accumulation and subsequent mTOR (show FRAP1 Antibodies) inactivation, which had an inhibitory effect on dendritic cells in mouse model of inflammatory bowel disease.
Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.
Substrate binding promotes formation of the Skp1 (show SKP1 Antibodies)-Cul1-Fbxl3 (show FBXL3 Antibodies) (SCF (show KITLG Antibodies)(Fbxl3 (show FBXL3 Antibodies))) protein complex.
Rictor (show RICTOR Antibodies) forms a complex with Cullin-1 to promote SGK1 (show SGK1 Antibodies) ubiquitination and destruction.
Skp2 and Cul1 expression is repressed by GATA2 (show GATA2 Antibodies), thereby inhibiting ubiquitin/proteasome-dependent degradation of p21(WAF1 (show CDKN1A Antibodies)) and p27(Kip1 (show CDKN1B Antibodies)), inducing their accumulation, and suppressing hematopoietic stem cell growth
Analysis of cell cycle regulatory genes reveals defective induction of the c-Myc:CUL1 ubiquitin ligase pathway in B cells from CD22-deficient mice in the context of a C57BL/6 genetic background, following IgM ligation compared with wild-type B cells.
Cul7 (show CUL7 Antibodies) forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8 (show FBXW8 Antibodies).
SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation
Results show that Cullin-1-mediated protein degradation plays an essential role in the correct allocation of neural crest fates during embryogenesis.
The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).
a new viable recessive allele of the Arabidopsis CULLIN1 gene in the non-reference Wassilewskija (Ws-4 (show SOX10 Antibodies)) accession, was identified.
icu13 is a novel recessive allele of AUXIN RESISTANT6 (AXR6), which encodes CULLIN1, an invariable component of the SCF (show KITLG Antibodies) complex.[ICU13] [ncurvata13]
Genetic and physiological data to directly demonstrate that AtCUL1 is necessary for normal JA responses are presented.
A viable and fertile weak allele of CUL1, called cul1-6, is described.
CUL1 is required for TOC1 degradation and suggests that this protein is the functional cullin circadian clock.
The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.
the first reported allele of CUL1 to directly affect subunit interactions at the CUL1 C terminus
CUL1-based SCF (show KITLG Antibodies) E3 ligase activity is required for Della protein degradation.
Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).
, cullin 1