Browse our Cullin 1 Proteins (CUL1)

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Cullin 1 Proteins (CUL1)
On are 9 Cullin 1 (CUL1) Proteins from 6 different suppliers available. Additionally we are shipping Cullin 1 Antibodies (134) and Cullin 1 Kits (4) and many more products for this protein. A total of 154 Cullin 1 products are currently listed.
ATCUL1, AUXIN RESISTANT 6, AXR6, cul1, Cullin-1, cullin 1, LOC100282292, T10P11.26, T10P11_26, wu:fc13a10, wu:fi43h07, wu:fj43a08, zgc:55483, zgc:55747, zgc:77500, zgc:111899
list all proteins Gene Name GeneID UniProt
CUL1 8454 Q13616
CUL1 26965 Q9WTX6
Rat CUL1 CUL1 362356  

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Cullin 1 Proteins (CUL1) by Origin

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Top referenced Cullin 1 Proteins

  1. Human Cullin 1 Protein expressed in Escherichia coli (E. coli) - ABIN667243 : Kipreos, Lander, Wing, He, Hedgecock: cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family. in Cell 1996 (PubMed)
    Show all 2 references for 667243

  2. Human Cullin 1 Protein expressed in Wheat germ - ABIN1350756 : Mallampalli, Glasser, Coon, Chen: Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. in Cell cycle (Georgetown, Tex.) 2013 (PubMed)

More Proteins for Cullin 1 Interaction Partners

Cow (Bovine) Cullin 1 (CUL1) interaction partners

  1. The SCF (show KITLG Proteins)-complex gene expression has been characterized during bovine preimplantation development (show MTA2 Proteins).

  2. Around the time of major gene activation, expression of cullin 1 switches from transcript variant 1 to transcript variant 3.

Human Cullin 1 (CUL1) interaction partners

  1. Data suggest that cullin1 (Cul1) may constitute a potential therapeutic target in renal cell carcinoma (show MOK Proteins) (RCC (show XRCC1 Proteins)).

  2. Cul1 promoted mTORC1 activity and cap-dependent translation by enhancing the ubiquitination and degradation of DEPTOR (show DEPTOR Proteins). eIF4F (show EIF4A2 Proteins) suppression inhibited the promoting effect of Cul1 on melanoma cell proliferation.

  3. Data show that melanoma antigen, family C, 2 protein (MAGE-C2) binds with RING-box protein 1 (Rbx1) and Cullin 1, and regulates cyclin E stability in melanoma cells.

  4. High Cul1 expression predicts worse 5-year overall and disease-specific survival rates in HCC (show FAM126A Proteins) patients.

  5. Nedd8 (show NEDD8 Proteins)(Q40E) cannot induce the same structural effect on Cul1-Rbx1 as wild-type Nedd8 (show NEDD8 Proteins).

  6. Cullin-1 has been deeply implicated in the pathogenesis and development of prostate cancer

  7. Increased CUL1 expression in CRC (show CALR Proteins) cells significantly promoted cell migration and invasion abilities in vitro and peritoneal metastasis in vivo through inducing high expression of MMPs.

  8. Our data indicated that Cul1 expression significantly increased in human glioma, and it may be involved in proliferation, migration and invasion of glioma cells.

  9. In papillary thyroid carcinoma, cytoplasmic expression of Cul1 was correlated with tumor occurrence, N stage and Cyclin D1 (show CCND1 Proteins) expression. Nuclear Cul1 expression was negatively correlated with tumor occurence.

  10. We discuss how these results can explain the rapid association of Cdc34 (show CDC34 Proteins) and SCF (show KITLG Proteins).

Mouse (Murine) Cullin 1 (CUL1) interaction partners

  1. Lysine 29-linkage of ASK1 by Skp1-Cullin 1-Fbxo21 ubiquitin ligase complex is required for antiviral innate response.

  2. Substrate binding promotes formation of the Skp1 (show SKP1 Proteins)-Cul1-Fbxl3 (show FBXL3 Proteins) (SCF (show KITLG Proteins)(Fbxl3 (show FBXL3 Proteins))) protein complex.

  3. Rictor forms a complex with Cullin-1 to promote SGK1 (show SGK1 Proteins) ubiquitination and destruction.

  4. Skp2 and Cul1 expression is repressed by GATA2 (show GATA2 Proteins), thereby inhibiting ubiquitin/proteasome-dependent degradation of p21(WAF1 (show CDKN1A Proteins)) and p27(Kip1 (show CDKN1B Proteins)), inducing their accumulation, and suppressing hematopoietic stem cell growth

  5. Analysis of cell cycle regulatory genes reveals defective induction of the c-Myc:CUL1 ubiquitin ligase pathway in B cells from CD22-deficient mice in the context of a C57BL/6 genetic background, following IgM ligation compared with wild-type B cells.

  6. Cul7 forms a heterodimeric complex with Cul1 in a manner dependent on Fbxw8 (show FBXW8 Proteins).

  7. SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation

Xenopus laevis Cullin 1 (CUL1) interaction partners

  1. Results show that Cullin-1-mediated protein degradation plays an essential role in the correct allocation of neural crest fates during embryogenesis.

Arabidopsis thaliana Cullin 1 (CUL1) interaction partners

  1. The axr6-101 phenotype is caused by the E716K substitution of the CUL1 protein, which is likely to affect its ability to bind to the C-terminal RING domain of RING-box 1 (RBX1).

  2. a new viable recessive allele of the Arabidopsis CULLIN1 gene in the non-reference Wassilewskija (Ws-4 (show SOX10 Proteins)) accession, was identified.

  3. icu13 is a novel recessive allele of AUXIN RESISTANT6 (AXR6), which encodes CULLIN1, an invariable component of the SCF (show KITLG Proteins) complex.[ICU13] [ncurvata13]

  4. Genetic and physiological data to directly demonstrate that AtCUL1 is necessary for normal JA responses are presented.

  5. A viable and fertile weak allele of CUL1, called cul1-6, is described.

  6. CUL1 is required for TOC1 degradation and suggests that this protein is the functional cullin circadian clock.

  7. The disruption of the CAND1-CUL1 interaction results in an increased abundance of assembled SCF(TIR1) complex; stabilization of the CAND1-CUL1 interaction diminishes SCF(TIR1) complex abundance.

  8. the first reported allele of CUL1 to directly affect subunit interactions at the CUL1 C terminus

  9. CUL1-based SCF (show KITLG Proteins) E3 ligase activity is required for Della protein degradation.

Cullin 1 (CUL1) Protein Profile

Protein Summary

Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).

Alternative names and synonyms associated with Cullin 1 (CUL1)

  • cullin-1 (LOC100282292)
  • cullin 1 (cul1)
  • cullin-1 (ATEG_00491)
  • cullin-1 (EDI_072700)
  • cullin-1 (EDI_264400)
  • cullin-1 (SJAG_02591)
  • Cullin-1 (BDBG_03785)
  • cullin 1a (cul1a)
  • cullin 1 (CUL1)
  • cullin 1 (Cul1)
  • cullin 1b (cul1b)
  • Protein CUL-1 (cul-1)
  • ATCUL1 protein
  • AUXIN RESISTANT 6 protein
  • AXR6 protein
  • cul1 protein
  • Cullin-1 protein
  • cullin 1 protein
  • LOC100282292 protein
  • T10P11.26 protein
  • T10P11_26 protein
  • wu:fc13a10 protein
  • wu:fi43h07 protein
  • wu:fj43a08 protein
  • zgc:55483 protein
  • zgc:55747 protein
  • zgc:77500 protein
  • zgc:111899 protein

Protein level used designations for Cullin 1 Proteins (CUL1)

cullin-1 , Cullin-1 , cullin 1 , CUL-1

100282292 Zea mays
734121 Xenopus (Silurana) tropicalis
4355245 Aspergillus terreus NIH2624
5880828 Entamoeba dispar SAW760
5884109 Entamoeba dispar SAW760
7047697 Schizosaccharomyces japonicus yFS275
8509782 Ajellomyces dermatitidis SLH14081
323883 Danio rerio
539792 Bos taurus
8454 Homo sapiens
26965 Mus musculus
734414 Xenopus laevis
420783 Gallus gallus
475512 Canis lupus familiaris
362356 Rattus norvegicus
407228 Bos taurus
100173991 Pongo abelii
825648 Arabidopsis thaliana
406816 Danio rerio
176466 Caenorhabditis elegans
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