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Changing Cyclin B3 levels showed that it accelerated progress to anaphase, even in the absence of spindle assembly checkpoint function.
Cyclin B3 protein signals were detected in germ cells in large cysts, possibly corresponding to spermatocytes at the preleptotene stage.
CCNB3 immunostaining was useful for differentiating BCOR (show BCOR Proteins)-CCNB3 from a group of 'Ewing-like sarcomas' and may contribute to the evaluation of treatment strategies for bone sarcomas.
This study adds to recent reports on the clinicopathologic spectrum of BCOR (show BCOR Proteins)-CCNB3 fusion-positive sarcomas, a newly emerging entity within the undifferentiated unclassified sarcoma category
Study provides a detailed description of the histologic spectrum, immunohistochemical features, and clinical characteristic of BCOR (show BCOR Proteins)-CCNB3 sarcoma justifying distinction from Ewing sarcoma with its typical EWS (show EWSR1 Proteins)/FUS (show FUS Proteins)-ETS (show ETS1 Proteins) translocations.
A new fusion was observed between BCOR (show BCOR Proteins) (encoding the BCL6 co-repressor (show BCOR Proteins)) and CCNB3 (encoding the testis-specific (show THEG Proteins) cyclin B3) on the X chromosome.
Increased expression of cyclin B3 maybe an important marker for identifying endoderm cells differentiated from human embryonic stem cells.
Depletion of cyclin B3 inhibits metaphase-anaphase transition as indicated by a well-sustained MI spindle and cyclin B1 (show CCNB1 Proteins) expression in meiotic oocytes.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as positive regulators of cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle. Different cyclins exhibit distinct expression and degradation patterns, which contribute to the temporal coordination of each mitotic event. Studies of similar genes in chicken and drosophila suggest that this cyclin may associate with CDC2 and CDK2 kinases, and may be required for proper spindle reorganization and restoration of the interphase nucleus. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, cyclin B3
, G2/mitotic-specific cyclin-B3
, g2/mitotic-specific cyclin-B3-like