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anti-Human Cyclin D2 Antibodies:
anti-Mouse (Murine) Cyclin D2 Antibodies:
anti-Rat (Rattus) Cyclin D2 Antibodies:
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Human Monoclonal Cyclin D2 Primary Antibody for IP, WB - ABIN967434
Meyerson, Harlow: Identification of G1 kinase activity for cdk6, a novel cyclin D partner. in Molecular and cellular biology 1994
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Human Polyclonal Cyclin D2 Primary Antibody for ICC, IF - ABIN4301609
Danielsson, Wiking, Mahdessian, Skogs, Ait Blal, Hjelmare, Stadler, Uhlén, Lundberg: RNA deep sequencing as a tool for selection of cell lines for systematic subcellular localization of all human proteins. in Journal of proteome research 2013
Show all 2 Pubmed References
Human Polyclonal Cyclin D2 Primary Antibody for WB - ABIN2801940
Ota, Suzuki, Nishikawa, Otsuki, Sugiyama, Irie, Wakamatsu, Hayashi, Sato, Nagai, Kimura, Makita, Sekine, Obayashi, Nishi, Shibahara, Tanaka, Ishii, Yamamoto, Saito, Kawai, Isono, Nakamura, Nagahari et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. ... in Nature genetics 2003
Show all 3 Pubmed References
Human Polyclonal Cyclin D2 Primary Antibody for IF (cc), IF (p) - ABIN738366
Wang, Wu, Gao, Chen, Gu, Ding, Guo: Elevated toll-like receptor 3 inhibits pancreatic ?-cell proliferation through G1 phase cell cycle arrest. in Molecular and cellular endocrinology 2013
The surface immune molecule CD274 (show CD274 Antibodies) plays a critical role in the proliferation of leukemia-initiating cells, LICs. The CD274 (show CD274 Antibodies)/JNK (show MAPK8 Antibodies)/Cyclin D2 pathway promotes the cell cycle entry of LIC.
High CCND2 expression is associated with Metastasis of Colorectal Cancer.
Mutation in the CCND2 gene is associated with acute myeloid leukemia (show BCL11A Antibodies).
data suggested that loss of CCND2 expression is closely associated with the promoter aberrant methylation
MiR (show MLXIP Antibodies)-497 significantly suppressed cell proliferation by arresting the cell cycle through the CCND2 protein.
cyclin D2 acts as regulator of cell cycle (show C13orf15 Antibodies) proteins affecting SAMHD1 (show SAMHD1 Antibodies)-mediated HIV-1 restriction in non-proliferating macrophages.
CCND2-AS1 (show PTGDR Antibodies) promotes glioma cells proliferation and growth in a process that involves Wnt (show WNT2 Antibodies) and beta-catenin (show CTNNB1 Antibodies)
CCND1 (show CCND1 Antibodies) is downregulated, whereas CCND2 is not, following ionizing radiation (IR) . Both CCND1 (show CCND1 Antibodies)- and CCND2-expressing MM cells arrested in S/G2 (show STRN3 Antibodies)/M, and did not differ in other cell-cycle proteins or sensitivity to IR.Differential expression of D-cyclin (show PCNA Antibodies) does not appear to affect cell-cycle response to IR, and is unlikely to underlie differential sensitivity to DNA damage.
the phosphorylation levels of ErbB2 (show ERBB2 Antibodies), ErbB3 (show ERBB3 Antibodies) and Akt (show AKT1 Antibodies) and the protein levels of cyclin D1 (show CCND1 Antibodies) were decreased by lapatinib treatment of HSC3, HSC4 and Ca9 (show CA9 Antibodies)-22 cells
miR (show MLXIP Antibodies)-155 overexpression plays a promoting role in the proliferative, migratory and invasive behavior of OSCC cells. Its effects on OSCC are possibly associated with its regulation of the BCL6 (show BCL6 Antibodies)/cyclin D2 axis.
Cyclin D1 (show CCND1 Antibodies) is indispensable for normal hematopoiesis; in its absence, cyclins D2 and D3 are also not expressed, preventing hematopoietic cell division and differentiation at its earliest stage. The results demonstrate that not all functions of individual D cyclins are redundant, and highlight a master role of cyclin D1 (show CCND1 Antibodies) in hematopoiesis.
we analyzed Cyclin D2(-/-) mice to test whether the ciliary margin zone (CMZ)is a source of retinal cells. Neurogenesis is diminished in Cyclin D2 mutants, leading to a reduction of RGCs in the ventral retina. In line with these findings, in the albino retina, the decreased production of ipsilateral RGCs is correlated with fewer Cyclin D2(+) cells.
We showed for the first time that progesterone-induced miR (show MLXIP Antibodies)-133a inhibited the proliferation of endometrial epithelial cells by downregulating cyclinD2.
NMB or NMBR (show NMBR Antibodies) silencing inhibited M-CSF (show CSF1R Antibodies)/c-Fms (show CSF1R Antibodies)-mediated downstream signaling pathways like activation of ERK (show EPHB2 Antibodies) and Akt (show AKT1 Antibodies) and induction of D-type cyclins, cyclin D1 (show CCND1 Antibodies) and D2.
Data (including data from studies in transgenic and knockout mice) suggest that Pkcz (protein kinase C zeta (show PRKCZ Antibodies)) activation is key for early compensatory pancreatic beta-cell proliferation in insulin (show INS Antibodies) resistance (overweight and diabetes type 2) by regulating downstream signal transduction components mTOR (mammalian target of rapamycin (show FRAP1 Antibodies) protein) and Ccnd2 (cyclin-D2).
miR (show MLXIP Antibodies)-26a regulated mouse hepatocyte proliferation by directly targeting the 3' untranslated regions of cyclin D2/cyclin E2 (show CCNE2 Antibodies).
NF-kappaB (show NFKB1 Antibodies)-miR (show MLXIP Antibodies)-195/497-Igf1r (show IGF1R Antibodies)/Insr (show INSR Antibodies)-Ccnd2/Ccne1 (show CCNE1 Antibodies) plays important roles in myogenesis.
Loss of N-myc (show MYCN Antibodies) significantly impairs the Sonic hedgehog (show SHH Antibodies) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2.
Activation of the ERK1/2 (show MAPK1/3 Antibodies) signalling pathway, increased phosphorylation of c-myc (show MYC Antibodies) and significantly increased expression of cyclin D2 protein, are demonstrated.
maternal dietary betaine supplementation during gestation inhibits hepatic cell proliferation in neonatal piglets, at least partly, through epigenetic regulation of hepatic CCND2 and PSEN1 (show PSEN1 Antibodies) genes via a STAT3 (show STAT3 Antibodies)-dependent pathway
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.
, G1/S-specific cyclin-D2
, G1/S-specific cyclin D2
, vin-1 proto-oncogene