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Browse our E2F4 Proteins (E2F4)

Full name:
E2F Transcription Factor 4, P107/p130-Binding Proteins (E2F4)
On are 4 E2F Transcription Factor 4, P107/p130-Binding (E2F4) Proteins from 3 different suppliers available. Additionally we are shipping E2F4 Antibodies (85) and E2F4 Kits (1) and many more products for this protein. A total of 99 E2F4 products are currently listed.
2010111M04Rik, AI427446, cb735, E2F-4, E2F4, zgc:111879
list all proteins Gene Name GeneID UniProt
E2F4 104394 Q8R0K9
E2F4 1874 Q16254
Rat E2F4 E2F4 100360427  

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E2F4 Proteins (E2F4) by Origin

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More Proteins for E2F4 Interaction Partners

Mouse (Murine) E2F Transcription Factor 4, P107/p130-Binding (E2F4) interaction partners

  1. E2f4 and E2f5 display overlapping roles in controlling the normal development of the male reproductive system.

  2. Following stress exposure, E2F4-p130 complexes are lost rapidly along with the presence of E2F4 at E2F (show E2F1 Proteins)-containing B-Myb (show MYBL2 Proteins) promoter sites.

  3. E2F4 is part of a transcriptional repressor complex comprising p130 and HDAC1 (show HDAC1 Proteins) in cardiac myocytes. Relief from E2F4-dependent gene silencing induces the expression of pro-apoptotic genes.

  4. In terminally differentiated cells, common KDM5A (show KDM5A Proteins) and E2F4 gene targets were bound by the pRB (show PGR Proteins)-related protein p130, a DREAM complex component.

  5. We report here a new cellular function of p27 (show CDKN1B Proteins) as a transcriptional regulator in association with p130/E2F4 complexes that could be relevant for tumorigenesis.

  6. Induction of Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling in mouse mesenchymal stem cells is associated with activation of the p130 and E2f4 and formation of the p130/Gsk3beta/beta-catenin (show CTNNB1 Proteins) complex.

  7. E2F4 plays an important role in enabling osteoblast progenitors to exit the cell cycle and subsequently differentiate thereby contributing to the commitment of these cells to the bone lineage.

  8. Our data indicate that E2F4 is required for cardiomyocyte proliferation and suggest a function for E2F4 in mitosis

  9. E2F4 controls cell cycle exit through different mechanisms.

  10. interactions are regulated by G1 cyclin/cyclin (show PCNA Proteins)-dependent kinase (show CDK1 Proteins)-coordinated phosphorylation of endogenous pocket proteins

Human E2F Transcription Factor 4, P107/p130-Binding (E2F4) interaction partners

  1. Integrative genomic analyses confirm that E2F4 or E2F1 (show E2F1 Proteins) expression level is high in liposarcoma patients which associate with unfavorable prognosis.

  2. This study found evidence that the number of triplet AGC (show ACAN Proteins) repeats in the E2F4 gene may play a role in the susceptibility to early-onset colorectal cancer.

  3. PHF8 (show PHF8 Proteins) reduces the H3K9me2 level at the E2F4 transcriptional start site, demonstrating a direct function of PHF8 (show PHF8 Proteins) in endothelial E2F4 gene regulation

  4. cell cycle-dependent transcription of the TRAIP (show TRAIP Proteins) gene by E2F1 (show E2F1 Proteins), E2F2 (show E2F2 Proteins), and E2F4 and rapid protein degradation leads to cell cycle-dependent expression with a maximum in G2/M

  5. Authors show that BRCA1 and RAD17 (show RAD17 Proteins) genes, whose derived proteins play a pivotal role in DNA damage repair, are transcriptional targets of gain-of-function mutant p53 (show TP53 Proteins) proteins.

  6. Data suggest that aberrant cell cycle activation in Ewing sarcoma is due to the de-repression of transcription factor E2F targets of transcriptional induction and physical recruitment of E2F3 by fusion protein EWS (show EWSR1 Proteins)-FLI1 (show FLI1 Proteins) replacing E2F4 on their promoters.

  7. The inverse immunohistochemical relationship between E2F1 (show E2F1 Proteins) and E2F4 indicates a possible mechanistic interlink in colorectal cancer.

  8. E2F4 promoter occupancy is globally associated with p53 (show TP53 Proteins)-repression targets, but not with p53 (show TP53 Proteins) activation targets.

  9. cancer-associated E2F4 mutations enhance the capacity of colorectal cancer cells to grow without anchorage, thereby contributing to tumor progression.

  10. Analysis data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors.

E2F4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.

Alternative names and synonyms associated with E2F4

  • E2F transcription factor 4, p107/p130-binding (E2F4)
  • E2F transcription factor 4, p107/p130-binding (e2f4)
  • E2F transcription factor 4 (E2f4)
  • E2F transcription factor 4, p107/p130-binding (E2f4)
  • E2F transcription factor 5 (e2f5)
  • 2010111M04Rik protein
  • AI427446 protein
  • cb735 protein
  • E2F-4 protein
  • E2F4 protein
  • zgc:111879 protein

Protein level used designations for E2F4

E2F transcription factor 4, p107/p130-binding , transcription factor E2F4 , E2F-4 , p107/p130-binding protein , E2F transcription factor 4

454158 Pan troglodytes
696864 Macaca mulatta
100038079 Xenopus (Silurana) tropicalis
100600930 Nomascus leucogenys
104394 Mus musculus
1874 Homo sapiens
100360427 Rattus norvegicus
446541 Xenopus laevis
769430 Gallus gallus
611243 Canis lupus familiaris
525428 Bos taurus
100522677 Sus scrofa
402908 Danio rerio
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